Epigenetic regulation of diverse regulated cell death modalities in cardiovascular disease: Insights into necroptosis, pyroptosis, ferroptosis, and cuproptosis
Redox Biology,
Год журнала:
2024,
Номер
76, С. 103321 - 103321
Опубликована: Авг. 19, 2024
Cell
death
constitutes
a
critical
component
of
the
pathophysiology
cardiovascular
diseases.
A
growing
array
non-apoptotic
forms
regulated
cell
(RCD)-such
as
necroptosis,
ferroptosis,
pyroptosis,
and
cuproptosis-has
been
identified
is
intimately
linked
to
various
conditions.
These
RCD
are
governed
by
genetically
programmed
mechanisms
within
cell,
with
epigenetic
modifications
being
common
crucial
regulatory
method.
Such
include
DNA
methylation,
RNA
histone
acetylation,
non-coding
RNAs.
This
review
recaps
roles
modifications,
RNAs
in
diseases,
well
which
regulate
key
proteins
involved
death.
Furthermore,
we
systematically
catalog
existing
pharmacological
agents
targeting
novel
their
action
article
aims
underscore
pivotal
role
precisely
regulating
specific
pathways
thus
offering
potential
new
therapeutic
avenues
that
may
prove
more
effective
safer
than
traditional
treatments.
Язык: Английский
Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 7, 2025
Cardiovascular
diseases
represent
the
principal
cause
of
death
and
comorbidity
among
people
with
diabetes.
Ferroptosis,
an
iron-dependent
non-apoptotic
regulated
cellular
characterized
by
lipid
peroxidation,
is
involved
in
pathogenesis
diabetic
cardiovascular
diseases.
The
susceptibility
to
ferroptosis
hearts
possibly
related
myocardial
iron
accumulation,
abnormal
metabolism
excess
oxidative
stress
under
hyperglycemia
conditions.
Accumulating
evidence
suggests
can
be
therapeutic
target
for
This
review
summarizes
ferroptosis-related
mechanisms
novel
choices
targeting
pathways.
Further
study
on
ferroptosis-mediated
cardiac
injury
enhance
our
understanding
pathophysiology
provide
more
potential
choices.
Язык: Английский
Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects
Bone Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Фев. 25, 2025
Abstract
The
muscular
system
plays
a
critical
role
in
the
human
body
by
governing
skeletal
movement,
cardiovascular
function,
and
activities
of
digestive
organs.
Additionally,
muscle
tissues
serve
an
endocrine
function
secreting
myogenic
cytokines,
thereby
regulating
metabolism
throughout
entire
body.
Maintaining
requires
iron
homeostasis.
Recent
studies
suggest
that
disruptions
ferroptosis,
form
iron-dependent
cell
death,
are
essential
contributors
to
progression
wide
range
diseases
disorders,
including
sarcopenia,
cardiomyopathy,
amyotrophic
lateral
sclerosis.
Thus,
comprehensive
overview
mechanisms
ferroptosis
these
conditions
is
crucial
for
identifying
potential
therapeutic
targets
developing
new
strategies
disease
treatment
and/or
prevention.
This
review
aims
summarize
recent
advances
understanding
molecular
underlying
context
injury,
as
well
associated
disorders.
Moreover,
we
discuss
within
pathway
possible
managing
Finally,
shed
light
on
current
limitations
future
prospects
interventions
targeting
ferroptosis.
Язык: Английский
Baicalein disrupts TGF-β-induced EMT in pancreatic cancer by FTO-dependent m6A demethylation of ZEB1
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research,
Год журнала:
2025,
Номер
unknown, С. 119969 - 119969
Опубликована: Апрель 1, 2025
Язык: Английский
Wen-Shen-Tong-Luo-Zhi-Tong-Decoction inhibits bone loss in senile osteoporosis model mice by promoting testosterone production
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
338, С. 119033 - 119033
Опубликована: Ноя. 7, 2024
Язык: Английский
Targeting autophagy in diabetic cardiomyopathy: From molecular mechanisms to pharmacotherapy
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
175, С. 116790 - 116790
Опубликована: Май 22, 2024
Diabetic
cardiomyopathy
(DCM)
is
a
cardiac
microvascular
complication
caused
by
metabolic
disorders.
It
characterized
myocardial
remodeling
and
dysfunction.
The
pathogenesis
of
DCM
associated
with
abnormal
cellular
metabolism
organelle
accumulation.
Autophagy
thought
to
play
key
role
in
the
diabetic
heart,
growing
body
research
suggests
that
modulating
autophagy
may
be
potential
therapeutic
strategy
for
DCM.
Here,
we
have
summarized
major
signaling
pathways
involved
regulation
DCM,
including
Adenosine
5'-monophosphate-activated
protein
kinase
(AMPK),
mechanistic
target
rapamycin
(mTOR),
Forkhead
box
subfamily
O
proteins
(FOXOs),
Sirtuins
(SIRTs),
PTEN-inducible
1
(PINK1)/Parkin.
Given
significant
further
identified
natural
products
chemical
drugs
as
regulators
treatment
This
review
help
better
understand
mechanism
promote
their
clinical
application.
Язык: Английский