Springer eBooks, Год журнала: 2022, Номер unknown, С. 1 - 37
Опубликована: Янв. 1, 2022
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(5), С. 2619 - 2619
Опубликована: Март 5, 2021
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical symptoms distortion of tissues. It primarily damages cartilage, causing pain, swelling, stiffness around the joint. major cause disability pain. The prevalence OA expected to increase gradually with aging population increasing obesity. Many potential therapeutic advances have been made in recent years due improved understanding underlying mechanisms, diagnosis, management OA. Embryonic stem cells induced pluripotent differentiate into chondrocytes or mesenchymal (MSCs) can be used as source injectable treatments cavity. MSCs are known most studied cell therapy products cell-based owing their ability immunomodulatory properties. They improve cartilage recovery ultimately restore healthy joints. However, despite currently available therapies research, unfulfilled medical needs persist for treatment. In this review, we focused on contents non-cellular cellular OA, briefly summarized results trials lay solid application basis research.
Язык: Английский
Процитировано
594
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6405 - 6405
Опубликована: Март 29, 2023
Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast majority of social OA burden related to hips knees. The prevalence knee varied across studies such differences are reflected by heterogeneity data reported conducted worldwide. complete understanding pathogenetic mechanisms underlying this pathology essential. inflammatory process starts in synovial membrane with activation immune system, involving both humoral cellular mediators. crucial role played so-called “damage-associated molecular patterns” (DAMPs). Mesenchymal stem cells (MSCs) may be promising option among all possible therapeutic options. However, many issues still debated, as best cell source, their nature, right amount. Further needed clarify remaining doubts. This review provides an overview recent relevant on mechanism cartilage damage OA, including current approaches regenerative medicine.
Язык: Английский
Процитировано
161
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Янв. 16, 2023
Abstract Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator cuff injury, are the most common soft tissue injuries. In situations, surgical tendon/ligament reconstruction is necessary for treating However, a significant number of cases failed because healing enthesis occurs through scar formation rather than regeneration transitional tissue. recent years, therapeutic potential mesenchymal stem cells (MSCs) has been well documented in animal clinical studies, chronic paraplegia, non-ischemic heart failure, osteoarthritis knee. MSCs multipotent cells, which have self-renewability ability to differentiate into wide variety chondrocytes, osteoblasts, adipocytes. Numerous studies suggested that could promote angiogenesis cell proliferation, reduce inflammation, produce large bioactive molecules involved repair. These effects likely mediated by paracrine mechanisms MSCs, particularly release exosomes. Exosomes, nano-sized extracellular vesicles (EVs) with lipid bilayer membrane structure, naturally released various types. They play an essential role intercellular communication transferring lipids, proteins, nucleic acids, mRNAs miRNAs, between influence physiological pathological processes recipient cells. Exosomes shown facilitate repair regeneration. Herein, we discuss prospective applications MSC-derived exosomes TBI We also review roles MSC–EVs underlying their on promoting tendon–bone healing. At last, present challenges future research directions. Graphical
Язык: Английский
Процитировано
159
Journal of Extracellular Vesicles, Год журнала: 2021, Номер 10(14)
Опубликована: Дек. 1, 2021
Extracellular vesicles (EVs) are lipid-bilayer membrane structures secreted by most cell types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic acids, influence various pathophysiological processes in both parent recipient cells. Compared to obtained from body fluids or culture supernatants, isolated directly tissues possess a number advantages, including tissue specificity, accurate reflection microenvironment, etc., thus, attention should be paid tissue-derived (Ti-EVs). Ti-EVs present interstitium play pivotal roles intercellular communication. Moreover, provide an excellent snapshot interactions among types with common histological background. Thus, may used gain insights into development progression diseases. To date, extensive investigations have focused on role fluid-derived culture-derived EVs; however, studies remains insufficient. Herein, we summarize latest advances for cancers non-cancer We propose future application basic research clinical practice. Workflows Ti-EV isolation characterization between diseases reviewed compared. discuss current issues associated potential directions.
Язык: Английский
Процитировано
144
Biomaterials, Год журнала: 2021, Номер 279, С. 121216 - 121216
Опубликована: Окт. 27, 2021
Язык: Английский
Процитировано
128
Small, Год журнала: 2021, Номер 17(50)
Опубликована: Июль 21, 2021
Abstract Recovery from bone, osteochondral, and cartilage injuries/diseases has been burdensome owing to the damaged vasculature of large defects and/or avascular nature leading a lack nutrients supplying cells. However, traditional means treatment such as microfractures cell‐based therapy only display limited efficacy due inability ensure cell survival potential aggravation surrounding tissues. Exosomes have recently emerged powerful tool for this tissue repair with its complex content transcription factors, proteins, targeting ligands, well unique ability home in on target cells thanks phospholipidic nature. They are engineered serve specialized applications including enhancing repair, anti‐inflammation, regulating homeostasis, etc. via physical, chemical, biological modulations deriving culture environments. This review focuses engineering functionalize exosomes regeneration, an emphasis conditions osteoarthritis, osteoporosis, osteonecrosis. Finally, future implications exosome development will be given alongside combination other strategies improve therapeutic osteochondral niche.
Язык: Английский
Процитировано
123
Analytical and Bioanalytical Chemistry, Год журнала: 2022, Номер 414(24), С. 7123 - 7141
Опубликована: Авг. 13, 2022
Язык: Английский
Процитировано
90
ACS Nano, Год журнала: 2022, Номер 16(12), С. 19665 - 19690
Опубликована: Дек. 13, 2022
Joint diseases are one of the most common causes morbidity and disability worldwide. The main that affect joint cartilage osteoarthritis rheumatoid arthritis, which require chronic treatment focused on symptomatic relief. Conventional drugs administered through systemic or intra-articular routes have low accumulation and/or retention in articular cartilage, causing dose-limiting toxicities reduced efficacy. Therefore, there is an urgent need to develop improved strategies for drug delivery, particular, use micro- nanotechnology-based methods. Encapsulation therapeutic agents delivery systems reduces efflux from protects against rapid cellular enzymatic clearance following injection. Consequently, decreases side effects increases efficacy due enhanced space. Additionally, frequency administration reduced, as enable sustained release. This review summarizes various advanced systems, such nano- microcarriers, developed diseases.
Язык: Английский
Процитировано
88
Smart Medicine, Год журнала: 2022, Номер 1(1)
Опубликована: Дек. 1, 2022
Osteoarthritis (OA) is a common disease that endangers millions of middle-aged and elderly people worldwide. Researchers from different fields have made great efforts achieved remarkable progress in the pathogenesis treatment OA. However, there still no cure for In this review, we discuss OA summarize current clinical therapies. Moreover, introduce various natural synthetic biomaterials drug release, cartilage transplantation, joint lubricant during treatment. We also present our perspectives insights on future. hope review will foster communication collaboration among biological, clinical, biomaterial researchers, paving way therapeutic breakthroughs.
Язык: Английский
Процитировано
82
International Journal of Oral Science, Год журнала: 2022, Номер 14(1)
Опубликована: Авг. 5, 2022
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss and accounts for major source of pain disability worldwide. However, effective strategies repair are lacking, patients with advanced OA usually need replacement. Better comprehending pathogenesis may lead to transformative therapeutics. Recently studies have reported that exosomes act as new means cell-to-cell communication delivering multiple bioactive molecules create particular microenvironment tunes behavior. Specifically, exosome cargos, such noncoding RNAs (ncRNAs) proteins, play crucial role in progression regulating the proliferation, apoptosis, autophagy, inflammatory response cells, rendering them promising candidates monitoring treatment. This review systematically summarizes current insight regarding biogenesis function their potential therapeutic tools targeting OA, suggesting realms improve management.
Язык: Английский
Процитировано
72