Nano Research, Год журнала: 2024, Номер 17(10), С. 8942 - 8976
Опубликована: Июль 13, 2024
Язык: Английский
Progress in Materials Science, Год журнала: 2023, Номер 135, С. 101091 - 101091
Опубликована: Фев. 10, 2023
Язык: Английский
Процитировано
92
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126914 - 126914
Опубликована: Сен. 15, 2023
Язык: Английский
Процитировано
62
ACS Nano, Год журнала: 2024, Номер 18(31), С. 20101 - 20110
Опубликована: Июль 23, 2024
Osteoarthritis (OA) is a prevalent degenerative disease that afflicts more than 250 million people worldwide, impairing their mobility and quality of life. However, conventional drug therapy palliative. Exosomes (Exo), although with the potential to fundamentally repair cartilage, face challenges in efficient enrichment delivery. In this study, we developed magnetic polysaccharide hydrogel particles as microcarriers for synergistic OA. The were composed modified natural polysaccharides, hyaluronic acid (HAMA), chondroitin sulfate (CSMA), generated from microfluidic electrospray combination cryogelation process. Magnetic nanoparticles spiny structures capable capturing stem cell Exo encapsulated within together an anti-inflammatory diclofenac sodium (DS). released DS had effect alleviating OA symptoms promoting cartilage repair. vitro vivo results demonstrated excellent performance microcarrier treatment. We believe work has other related diseases.
Язык: Английский
Процитировано
19
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 15, 2024
Abstract Hydrogels are a class of highly absorbent and easily modified polymer materials suitable for use as slow-release carriers drugs. Gene therapy is specific can overcome the limitations traditional tissue engineering techniques has significant advantages in repair. However, therapeutic genes often affected by cellular barriers enzyme sensitivity, carrier loading essential. Therapeutic gene hydrogels well these difficulties. Moreover, gene-therapeutic have made considerable progress. This review summarizes recent research on treatment damage through summary most current frontiers. We initially introduce classification their cross-linking methods, followed detailed overview types modifications genes, discussion characterization features, design release, an applications engineering. Finally, we provide comments look forward to shortcomings future directions therapy. hope that this article will researchers related fields with more comprehensive systematic strategies repair further promote development field Graphical abstract
Язык: Английский
Процитировано
16
Advanced Science, Год журнала: 2023, Номер 11(5)
Опубликована: Дек. 11, 2023
Abstract Destruction of cartilage due to the abnormal remodeling subchondral bone (SB) leads osteoarthritis (OA), and restoring chondro‐bone metabolic homeostasis is key treatment OA. However, traditional intra‐articular injections for OA cannot directly break through barrier reach SB. In this study, hydrothermal method used synthesize ultra‐small size (≈5 nm) selenium‐doped carbon quantum dots (Se‐CQDs, SC), which conjugated with triphenylphosphine (TPP) create TPP‐Se‐CQDs (SCT). Further, SCT dynamically complexed hyaluronic acid modified aldehyde methacrylic anhydride (AHAMA) construct highly permeable micro/nano hydrogel microspheres (SCT@AHAMA) homeostasis. vitro experiments confirmed that selenium atoms scavenged reactive oxygen species (ROS) from mitochondria mononuclear macrophages, inhibited osteoclast differentiation function, suppressed early chondrocyte apoptosis maintain a balance between matrix synthesis catabolism. vivo further demonstrated delivery system osteoclastogenesis H‐vessel invasion, thereby regulating initiation process inhibiting degeneration in conclusion, based on facilitate efficient penetration articular SB regulate metabolism treatment.
Язык: Английский
Процитировано
32
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 246, С. 125570 - 125570
Опубликована: Июнь 25, 2023
Язык: Английский
Процитировано
29
Small, Год журнала: 2023, Номер 20(19)
Опубликована: Дек. 6, 2023
Abstract The occurrence of osteoarthritis (OA) is highly associated with the inflammatory hypoxic microenvironment. Yet currently no attention has been paid to fabricating hypoxia‐responsive platforms for OA treatment. Herein, an injectable hydrogel microsphere system (HAM‐SA@HCQ) focusing on inflamed joint prepared methacrylate‐modified sulfonated azocalix[4]arene (SAC4A‐MA), methacrylated hyaluronic acid (HA‐MA), and dithiol‐terminated matrix metalloproteinase 13 (MMP‐13) sensitive peptide via a microfluidic device photo crosslinking technique, followed by encapsulation anti‐inflammatory drug hydroxychloroquine (HCQ) through host–guest interaction. Owing hydrophobic deep cavity, phenolic units, azo bonds SAC4A‐MA, microspheres show strong loading capacity, prominent reactive oxygen species (ROS) scavenging capability, specific release ability. In tissue microenvironment, undergo degradation excessive MMP‐13 HCQ under hypoxia condition, which synergizes ROS‐scavenging calixarene inhibit response macrophages. After being injected into OA‐inflamed joint, HAM‐SA@HCQ can significantly attenuate oxidative stress, downregulate expression hypoxia‐induced factor‐1α cytokines, prevent cartilage from destroyed.
Язык: Английский
Процитировано
28
European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 266, С. 116141 - 116141
Опубликована: Янв. 12, 2024
Язык: Английский
Процитировано
15
Advanced Science, Год журнала: 2024, Номер 11(19)
Опубликована: Март 13, 2024
Abstract Efferocytosis, an intrinsic regulatory mechanism to eliminate apoptotic cells, will be suppressed due the delayed apoptosis process in aging‐related diseases, such as osteoarthritis (OA). In this study, cartilage lesion‐localized hydrogel microspheres are developed remodel situ efferocytosis reverse senescence and recruit endogenous stem cells accelerate repair. Specifically, aldehyde‐ methacrylic anhydride (MA)‐modified hyaluronic acid (AHM), loaded with pro‐apoptotic liposomes (liposomes encapsulating ABT263, A‐Lipo) PDGF‐BB, namely A‐Lipo/PAHM, prepared by microfluidic photo‐cross‐linking techniques. By a degraded porcine explant OA model, lesion location experiment illustrated that aldehyde‐functionalized promote affinity for cartilage. vitro data showed A‐Lipo induced of senescent chondrocytes (Sn‐chondrocytes), which can then phagocytosed macrophages, remodeling facilitated protection normal maintained chondrogenic differentiation capacity MSCs. vivo experiments confirmed localized reversed promoted repair OA. It is believed strategy great significance tissue regeneration diseases.
Язык: Английский
Процитировано
12
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 27, 2024
With the accelerated aging tendency, osteoarthritis (OA) has become an intractable global public health challenge. Stem cells and their derivative exosome (Exo) have shown great potential in OA treatment. Research this area tends to develop functional microcarriers for stem cell Exo delivery improve therapeutic effect. Herein, we a novel system of Exo-encapsulated cell-recruitment hydrogel from liquid nitrogen-assisted microfluidic electrospray Benefited advanced droplet generation capability microfluidics mild cryogelation procedure, resultant particles show uniform size dispersion excellent biocompatibility. Moreover, acryloylated recruitment peptides SKPPGTSS are directly crosslinked within by ultraviolet irradiation, thus simplifying peptide coupling process preventing its premature release. The SKPPGTSS-modified can recruit endogenous promote cartilage repair released further enhances performance through synergistic effects. These features suggest that proposed microcarrier is promising candidate
Язык: Английский
Процитировано
11