Advances in stem cells and their niches, Год журнала: 2023, Номер unknown, С. 1 - 57
Опубликована: Янв. 1, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Июнь 8, 2023
Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical
Язык: Английский
Процитировано
474
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Март 16, 2024
Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their translation requires a deep understanding complex interplay between nanotechnology MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative versatile microphysiological platform to replicate dynamics tissue microenvironment studying nanotechnology-biology interactions. This review first covers recent advances applications OoCs ability mimic biophysical biochemical stimuli encountered by tissues. Next, integrating into OoCs, cellular responses behaviors may be investigated precisely controlling manipulating nanoscale environment. Analysis disease mechanisms, particularly bone, joint, muscle degeneration, drug screening development personalized medicine greatly facilitated using OoCs. Finally, future challenges directions outlined field, including advanced sensing technologies, integration immune-active components, enhancement biomimetic functionality. By highlighting emerging this aims advance intricate nanotechnology-MSK biology interface its significance in management, therapeutic interventional strategies.
Язык: Английский
Процитировано
11
Cells, Год журнала: 2024, Номер 13(9), С. 724 - 724
Опубликована: Апрель 23, 2024
Bone marrow (BM) acts as a dynamic organ within the bone cavity, responsible for hematopoiesis, skeletal remodeling, and immune system control. adipose tissue (BMAT) was long simply considered filler of space, but now it is known that instead constitutes an essential element BM microenvironment participates in homeostasis, influences health alters hematopoietic stem cell functions, contributes to commitment mesenchymal cells, provides effects homeostasis defense against infections, energy metabolism inflammation. BMAT has emerged significant contributor development progression various diseases, shedding light on its complex relationship with health. Notably, been implicated metabolic disorders, hematological malignancies, conditions. shown support proliferation tumor cells acute myeloid leukemia niche adipocytes have found protect cancer chemotherapy, contributing treatment resistance. Moreover, BMAT’s impact density remodeling can lead conditions like osteoporosis, where high levels are inversely correlated mineral density, increasing risk fractures. also associated diabetes, obesity, anorexia nervosa, varying individuals depending their weight status. Understanding interaction between different diseases may new therapeutic strategies.
Язык: Английский
Процитировано
11
Bone Research, Год журнала: 2024, Номер 12(1)
Опубликована: Авг. 21, 2024
Bone marrow stromal/stem cells (BMSCs) are generally considered as common progenitors for both osteoblasts and adipocytes in the bone marrow, but show preferential differentiation into rather than under aging, thus leading to senile osteoporosis. Accumulated evidences indicate that rejuvenation of BMSCs by autophagic enhancement delays aging. Here we synthetized demonstrated a novel autophagy activator, CXM102 could induce aged BMSCs, resulting BMSCs. Furthermore, significantly stimulated anabolism, reduced adipocytes, delayed loss middle-age male mice. Mechanistically, promoted transcription factor EB (TFEB) nuclear translocation favored formation vitro vivo. Moreover, decreased serum levels inflammation organ fibrosis, prolonger lifespan Our results indicated be used an inducer rejuvenate shed new lights on strategies osteoporosis healthyspan improvement.
Язык: Английский
Процитировано
8
Journal of Blood Medicine, Год журнала: 2024, Номер Volume 15, С. 313 - 323
Опубликована: Июль 1, 2024
Abstract: Sickle Cell Anemia (SCA) is a hereditary blood disorder characterized by the presence of abnormal hemoglobin, leading to formation sickle-shaped red cells. While extensive research has unraveled many aspects genetic and molecular basis SCA, role telomere dynamics in disease progression remains relatively unexplored frontier. This review seeks provide comprehensive examination biology within context aiming elucidate its potential impact on aging disease. The oxidative stress SCA explored, with particular focus how increased reactive oxygen species (ROS) may contribute accelerated shortening genomic instability. Furthermore, relationship between dysfunction cellular senescence investigated, shedding light premature cells this population. concludes summarizing key findings proposing therapeutic strategies targeting mitigate SCA. It also identifies gaps current understanding suggests avenues for future research, emphasizing importance further investigating advance our Anemia. exploration offers insights into mechanisms progression, paving way targeted interventions improved management. Keywords: sickle cell anemia, telomere, aging, hemoglobinopathy, shortening,
Язык: Английский
Процитировано
5
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
ABSTRACT The bone marrow (BM) microenvironment plays a crucial role in regulating hematopoiesis, yet the molecular and functional changes associated with aging humans remain poorly understood. Using single-cell RNA sequencing (scRNA-seq), we uncovered transcriptional shifts BM endothelial cells (EC) mesenchymal stem (MSC) during aging. Our analysis revealed that aged sinusoidal EC adopt prothrombotic, exhibit mitochondrial dysfunction, have compromised vascular function. Additionally, identified unique arterial subset, present only individuals, elongation senescence processes characterized by RAB13 expression. MSC from subjects displayed an impaired matrix remodeling epithelial-mesenchymal transition, driven partly subpopulation of THY1 + profibrotic stromal absent young subjects. Aged were also increased ATP-oxidative metabolism reduced protein folding capacity. Finally, using immunofluorescent imaging spatial transcriptomics, confirmed presence senescent samples significant age-related cell-cell communication within niche. In summary, this work provides comprehensive view diversity, cellular interactions, organization MSC, offering novel insights potential targets could be exploited for preventing aged-associated humans.
Язык: Английский
Процитировано
0
Frontiers in Hematology, Год журнала: 2025, Номер 4
Опубликована: Фев. 7, 2025
Hematopoietic stem cells (HSCs) undergo a functional decline during aging. The intrinsic characteristics of aged HSCs have been well-described and include strong myeloid bias, an increase in total number, decrease functionality transplantation. impact the bone marrow microenvironment, or niche, on is less well understood. It critical to understand changing condition niche aging, its ability support HSCs, as this could reveal very signals mechanisms needed improve HSC fitness. Furthermore, heterochronic transplantation provides approach test influence recipient young donor conversely, HSCs. Importantly, these experiments demonstrated that engraftment reduced if aged, can rejuvenate Here we will focus interactions between their microenvironment. We highlight current controversies, research gaps, future directions.
Язык: Английский
Процитировано
0
Expert Review of Anticancer Therapy, Год журнала: 2025, Номер unknown, С. 1 - 22
Опубликована: Март 23, 2025
Introduction Myeloid-derived suppressor cells (MDSCs) are a key immunosuppressive component in the tumor microenvironment, contributing to immune evasion and disease progression acute myeloid leukemia (AML) myelodysplastic syndromes (MDS).
Язык: Английский
Процитировано
0
Annals of Biomedical Engineering, Год журнала: 2024, Номер 52(11), С. 3009 - 3020
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
2
FEBS Letters, Год журнала: 2024, Номер 598(22), С. 2809 - 2828
Опубликована: Июль 24, 2024
In the last few decades, increasing human life expectancy has led to inflation of elderly population and consequently escalation age-related disorders. Biological aging been associated with accumulation somatic mutations in Hematopoietic Stem Cell (HSC) compartment, providing a fitness advantage HSCs leading clonal hematopoiesis, that includes non-malignant malignant conditions (i.e. Clonal Hematopoiesis Indeterminate Potential, Myelodysplastic Syndrome Acute Myeloid Leukemia). The Janus Kinase-Signal Transducer Activator Transcription (JAK-STAT) pathway is key player both normal hematopoiesis. STATs, particularly STAT3 STAT5, are greatly implicated immunity, inflammation, leukemia, aging. Here, pleiotropic functions JAK-STAT age-associated hematopoietic defects STAT5 inflammaging reviewed. Even though great progress made deciphering role further research required provide deeper understanding molecular mechanisms leukemogenesis, as well novel biomarkers therapeutic targets for improved management
Язык: Английский
Процитировано
2