Bone-related
diseases
caused
by
fractures,
bone
infection,
cancer,
and
so
on
have
posed
a
serious
threat
to
human
health.
The
drawbacks
of
traditional
implants
are
gradually
being
solved
through
the
design
construction
nanomaterials.
Among
them,
black
phosphorus
(BP)
is
widely
adopted
in
therapy
due
its
excellent
photo-responsiveness,
biodegradability,
biocompatibility,
which
considered
as
promising
solution
strategy.
This
latest
review
intended
provide
an
elaborate
introduction
recent
advances
BP-contained
nanomaterials
for
therapy,
covers
topics
from
strategies
classified
types
osteogenic
material,
including
3D
printing
scaffolds,
hydrogels,
fibrous
materials,
others,
well
research
works
function
BP
also
discussed.
Finally,
current
status
future
prospects
BP-based
summarized
reference
further
applications.
Advanced Materials,
Год журнала:
2024,
Номер
36(34)
Опубликована: Июнь 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
Medicinal Research Reviews,
Год журнала:
2024,
Номер
44(4), С. 1867 - 1903
Опубликована: Фев. 29, 2024
Over
the
past
decades,
emerging
evidence
in
literature
has
demonstrated
that
innervation
of
bone
is
a
crucial
modulator
for
skeletal
physiology
and
pathophysiology.
The
nerve-bone
axis
sparked
extensive
preclinical
clinical
investigations
aimed
at
elucidating
contribution
crosstalks
to
skeleton
metabolism,
homeostasis,
injury
repair
through
perspective
neurobiology.
To
date,
peripheral
nerves
have
been
widely
reported
mediate
growth
development
fracture
healing
via
secretion
neurotransmitters,
neuropeptides,
axon
guidance
factors,
neurotrophins.
Relevant
studies
further
identified
several
critical
neural
pathways
stimulate
profound
alterations
cell
biology,
revealing
complex
interplay
between
nerve
systems.
In
addition,
inspired
by
crosstalk,
novel
drug
delivery
systems
bioactive
materials
developed
emulate
facilitate
process
natural
neuromodulation,
eventually
boosting
osteogenesis
ideal
tissue
regeneration.
Overall,
this
work
aims
review
research
findings
contribute
deepening
current
understanding
axis,
bringing
forth
some
schemas
can
be
translated
into
scenario
highlight
roles
neuromodulation
system.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Май 28, 2024
The
repair
of
irregular
bone
tissue
suffers
severe
clinical
problems
due
to
the
scarcity
an
appropriate
therapeutic
carrier
that
can
match
dynamic
and
complex
damage.
Fortunately,
stimuli-responsive
in
situ
hydrogel
systems
are
triggered
by
a
special
microenvironment
could
be
ideal
method
regenerating
because
injectability,
gelatin,
spatiotemporally
tunable
drug
release.
Herein,
we
introduce
two
main
stimulus-response
approaches,
exogenous
endogenous,
forming
hydrogels
engineering.
First,
summarize
specific
distinct
responses
extensive
range
external
stimuli
(e.g.,
ultraviolet,
near-infrared,
ultrasound,
etc.)
form
created
from
biocompatible
materials
modified
various
functional
groups
or
hybrid
nanoparticles.
Furthermore,
“smart”
hydrogels,
which
respond
endogenous
physiological
environmental
temperature,
pH,
enzyme,
etc.),
achieve
gelation
one
injection
vivo
without
additional
intervention.
Moreover,
mild
chemistry
response-mediated
also
offer
fascinating
prospects
engineering,
such
as
Diels–Alder,
Michael
addition,
thiol-Michael
Schiff
reactions,
etc.
recent
developments
challenges
smart
their
application
administration
engineering
discussed
this
review.
It
is
anticipated
advanced
strategies
innovative
ideas
will
exploited
field
increase
quality
life
for
patients
with
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
The
skeleton
is
highly
innervated
by
numerous
nerve
fibers.
These
fibers,
in
addition
to
transmitting
information
within
the
bone
and
mediating
sensations,
play
a
crucial
role
regulating
tissue
formation
regeneration.
Traditional
engineering
(BTE)
often
fails
achieve
satisfactory
outcomes
when
dealing
with
large-scale
defects,
which
frequently
related
lack
of
effective
reconstruction
neurovascular
network.
In
recent
years,
increasing
research
has
revealed
critical
nerves
metabolism.
Nerve
fibers
regulate
cells
through
neurotransmitters,
neuropeptides,
peripheral
glial
cells.
Furthermore,
also
coordinate
vascular
immune
systems
jointly
construct
microenvironment
favorable
for
As
signaling
driver
formation,
neuroregulation
spans
entire
process
physiological
activities
from
embryonic
postmaturity
remodeling
repair.
However,
there
currently
comprehensive
summaries
these
regulatory
mechanisms.
Therefore,
this
review
sketches
out
function
during
Then,
we
elaborate
on
mechanisms
coupling
neuromodulation
immunity.
Finally,
discuss
several
novel
strategies
neuro-bone
(NBTE)
based
bone,
focusing
coordinated
regeneration
tissue.
Military Medical Research,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 3, 2025
Abstract
Bone
tissue
relies
on
the
intricate
interplay
between
blood
vessels
and
nerve
fibers,
both
are
essential
for
many
physiological
pathological
processes
of
skeletal
system.
Blood
provide
necessary
oxygen
nutrients
to
bone
tissues,
remove
metabolic
waste.
Concomitantly,
fibers
precede
during
growth,
promote
vascularization,
influence
cells
by
secreting
neurotransmitters
stimulate
osteogenesis.
Despite
critical
roles
components,
current
biomaterials
generally
focus
enhancing
intraosseous
vessel
repair,
while
often
neglecting
contribution
nerves.
Understanding
distribution
main
functions
in
is
crucial
developing
effective
engineering.
This
review
first
explores
anatomy
highlighting
their
vital
embryonic
development,
metabolism,
repair.
It
covers
innovative
regeneration
strategies
directed
at
accelerating
intrabony
neurovascular
system
over
past
10
years.
The
issues
covered
included
material
properties
(stiffness,
surface
topography,
pore
structures,
conductivity,
piezoelectricity)
acellular
biological
factors
[neurotrophins,
peptides,
ribonucleic
acids
(RNAs),
inorganic
ions,
exosomes].
Major
challenges
encountered
neurovascularized
materials
clinical
translation
have
also
been
highlighted.
Furthermore,
discusses
future
research
directions
potential
developments
aimed
producing
repair
that
more
accurately
mimic
natural
healing
tissue.
will
serve
as
a
valuable
reference
researchers
clinicians
novel
into
practice.
By
bridging
gap
experimental
practical
application,
these
advancements
transform
treatment
defects
significantly
improve
quality
life
patients
with
bone-related
conditions.
Abstract
Following
the
discovery
of
bone
as
an
endocrine
organ
with
systemic
influence,
bone-brain
interaction
has
emerged
a
research
hotspot,
unveiling
complex
bidirectional
communication
between
and
brain.
Studies
indicate
that
brain
can
influence
each
other’s
homeostasis
via
multiple
pathways,
yet
there
is
dearth
systematic
reviews
in
this
area.
This
review
comprehensively
examines
interactions
across
three
key
areas:
bone-derived
factors
on
function,
effects
brain-related
diseases
or
injuries
(BRDI)
health,
concept
skeletal
interoception.
Additionally,
discusses
innovative
approaches
biomaterial
design
inspired
by
mechanisms,
aiming
to
facilitate
through
materiobiological
aid
treatment
neurodegenerative
bone-related
diseases.
Notably,
integration
artificial
intelligence
(AI)
highlighted,
showcasing
AI’s
role
expediting
formulation
effective
targeted
strategies.
In
conclusion,
offers
vital
insights
into
mechanisms
suggests
advanced
harness
these
clinical
practice.
These
offer
promising
avenues
for
preventing
treating
impacting
skeleton
brain,
underscoring
potential
interdisciplinary
enhancing
human
health.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(9), С. 258 - 258
Опубликована: Сен. 8, 2024
Bioactive
glasses
(BGs)
have
attracted
significant
attention
in
the
biomaterials
field
due
to
their
ability
promote
soft
and
hard
tissue
regeneration
potential
for
various
clinical
applications.
BGs
offer
enriched
features
through
integration
of
different
therapeutic
inorganic
ions
within
composition.
These
can
trigger
specific
responses
body
conducive
a
battery
For
example,
zinc,
vital
trace
element,
plays
role
numerous
physiological
processes
human
body.
By
incorporating
inhibit
bacterial
growth,
exert
anti-inflammatory
effects,
modify
bioactivity,
promoting
better
with
surrounding
tissues
when
used
scaffolds
regeneration.
This
article
reviews
recent
developments
zinc-containing
(ZBGs),
focusing
on
synthesis,
physicochemical,
biological
properties.
ZBGs
represent
advancement
applications
extending
beyond
bone
Overall,
roles
hold
promise
applications,
such
as
engineering,
wound
healing,
biomedical
coatings.
Ongoing
research
continues
explore
benefits
optimize
properties
diverse
