Cancer stem cells: advances in knowledge and implications for cancer therapy

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 5, 2024

Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy treatment resistance still inevitable. Our review begins with brief introduction historical discoveries, original hypotheses, pathways regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, their crosstalk. We focus on role CSCs various therapeutic outcomes resistance, including how affect content alteration related molecules, CSCs-mediated clinical value targeting refractory, progressed or advanced tumors. summary, efficacy, method is difficult determine. Clarifying regulatory mechanisms biomarkers currently mainstream idea.

Язык: Английский

---

Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy

Biochimie, Год журнала: 2023, Номер 211, С. 57 - 67

Опубликована: Март 11, 2023

The Wnt/β-catenin signaling pathway is a highly conserved that involved in cell development, proliferation, differentiation, apoptosis and autophagy. Among these processes, autophagy occur physiologically during host defense the maintenance of intracellular homeostasis. Mounting evidence suggests crosstalk between Wnt/β-catenin-regulated has broad functional significance various diseases. Herein, we summarize recent studies understanding role autophagy, draw following conclusions: a) For apoptosis, regulation generally positive. However, small amount indicates presence negatively regulated relationship apoptosis; b) influences occurrence development by regulating autophagy-related factors, factors turn affect pathway; c) always balances molecular damage caused compensatory manner. Understanding specific different stages may provide new insights into progression related diseases pathway.

Язык: Английский

---

Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines

Pharmacology & Therapeutics, Год журнала: 2023, Номер 249, С. 108485 - 108485

Опубликована: Июль 3, 2023

Язык: Английский

---

Complex roles of autophagy in cancer development, immune evasion, and drug resistance

Drug Resistance Updates, Год журнала: 2024, Номер 78, С. 101170 - 101170

Опубликована: Ноя. 15, 2024

Язык: Английский

---

Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 6, 2025

Cancer stem cells (CSCs) are a small subset within the tumor mass significantly contributing to cancer progression through dysregulation of various oncogenic pathways, driving growth, chemoresistance and metastasis formation. The aggressive behavior CSCs is guided by several intracellular signaling pathways such as WNT, NF-kappa-B, NOTCH, Hedgehog, JAK-STAT, PI3K/AKT1/MTOR, TGF/SMAD, PPAR MAPK kinases, well extracellular vesicles exosomes, molecules cytokines, chemokines, pro-angiogenetic growth factors, which finely regulate CSC phenotype. In this scenario, microenvironment (TME) key player in establishment permissive niche, where engage intricate communications with diverse immune cells. "oncogenic" mainly represented B T lymphocytes, NK cells, dendritic Among macrophages exhibit more plastic adaptable phenotype due their different subpopulations, characterized both immunosuppressive inflammatory phenotypes. Specifically, tumor-associated (TAMs) create an milieu production plethora paracrine factors (IL-6, IL-12, TNF-alpha, TGF-beta, CCL1, CCL18) promoting acquisition stem-like, invasive metastatic TAMs have demonstrated ability communicate via direct ligand/receptor (such CD90/CD11b, LSECtin/BTN3A3, EPHA4/Ephrin) interaction. On other hand, exhibited capacity influence creating favorable for progression. Interestingly, bidirectional TME leads epigenetic reprogramming sustains malignant transformation. Nowadays, integration biological computational data obtained cutting-edge technologies (single-cell RNA sequencing, spatial transcriptomics, trajectory analysis) has improved comprehension biunivocal multicellular dialogue, providing comprehensive view heterogeneity dynamics CSCs, uncovering alternative mechanisms evasion therapeutic resistance. Moreover, combination biology will lead development innovative target therapies dampening CSC-TME Here, we aim elucidate most recent insights on complex interactions specifically TAMs, tracing exhaustive scenario from primary

Язык: Английский

---

SOX2 function in cancers: Association with growth, invasion, stemness and therapy response

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 156, С. 113860 - 113860

Опубликована: Окт. 20, 2022

Язык: Английский

---

Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathways

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 160, С. 114395 - 114395

Опубликована: Фев. 15, 2023

Colorectal cancer (CRC) is a dangerous form of that affects the gastrointestinal tract. It major global health concern, and aggressive behavior tumor cells makes it difficult to treat, leading poor survival rates for patients. One challenge in treating CRC metastasis, or spread, cancer, which cause death. In order improve prognosis patients with CRC, necessary focus on ways inhibit cancer's ability invade spread. Epithelial-mesenchymal transition (EMT) process linked spread cells, also known as metastasis. The transforms epithelial into mesenchymal ones, increasing their mobility other tissues. This has been shown be key mechanism progression colorectal (CRC), particularly cancer. activation EMT leads increases during this process, levels protein E-cadherin decrease while N-cadherin vimentin increase. contributes development resistance chemotherapy radiation therapy CRC. Non-coding RNAs, such long non-coding RNAs (lncRNAs) circular (circRNAs), play role regulating often through "sponge" microRNAs. Anti-cancer agents have suppress reduce cells. These findings suggest targeting related mechanisms may promising approach clinic.

Язык: Английский

---

Transcriptional regulation of autophagy and its implications in human disease

Cell Death and Differentiation, Год журнала: 2023, Номер 30(6), С. 1416 - 1429

Опубликована: Апрель 12, 2023

Язык: Английский

---

The Significance of Cancer Stem Cells and Epithelial–Mesenchymal Transition in Metastasis and Anti-Cancer Therapy

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2555 - 2555

Опубликована: Янв. 29, 2023

Cancer stem cells (CSCs) have been identified and characterized in both hematopoietic solid tumors. Their existence was first predicted by Virchow Cohnheim the 1870s. Later, many studies showed that CSCs can be isolated their expression of specific cell markers. The significance with respect to tumor biology anti-cancer treatment lies ability maintain quiescence very slow proliferation, indefinite self-renewal, differentiation, trans-differentiation such as epithelial-mesenchymal transition (EMT) its reverse process mesenchymal-epithelial (MET). for detachment, migration, extra- intravasation, invasion thereby completing all necessary steps metastatic cascade highlights metastasis. comprise cancer populations responsible growth, resistance therapies In this review, history CSC theory, identification characterization are described. contribution undergo EMT metastasis is discussed. Recently, novel strategies drug development focused on elimination specifically. unique functional molecular properties discussed possible therapeutic vulnerabilities anti-metastasis treatments. Prospectively, may provide precise personalized treatments improved efficiency fewer side effects leading better prognosis.

Язык: Английский

---

Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Май 5, 2023

Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis drug-resistance. Disheveled3 (DVL3) is involved malignant behaviors of cancer. However, the potential mechanism DVL3 remain elusive EMT CSLCs colorectal (CRC).

Язык: Английский

---