Emerging Role of Autophagy in Governing Cellular Dormancy, Metabolic Functions, and Therapeutic Responses of Cancer Stem Cells DOI Creative Commons
Meenakshi Tiwari,

Pransu Srivastava,

Sabiya Abbas

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 447 - 447

Published: March 4, 2024

Tumors are composed of heterogeneous populations dysregulated cells that grow in specialized niches support their growth and maintain properties. Tumor heterogeneity metastasis among the major hindrances exist while treating cancer patients, leading to poor clinical outcomes. Although factors determine tumor complexity remain largely unknown, several genotypic phenotypic changes, including DNA mutations metabolic reprograming provide with a survival advantage over host resistance therapeutics. Furthermore, presence specific population within mass, commonly known as stem (CSCs), is thought initiate formation, maintenance, resistance, recurrence. Therefore, these CSCs have been investigated detail recently potential targets treat prevent Understanding molecular mechanisms involved CSC proliferation, self-renewal, dormancy may important clues for developing effective therapeutic strategies. Autophagy, catabolic process, has long recognized regulate various physiological pathological processes. In addition regulating cells, recent studies identified critical role autophagy functions. Autophagy activated under adverse conditions promotes cellular survival, even cell death. Thus, it intriguing address whether or inhibits functions modulation can be used functions, either alone combination. This review describes roles regulation proliferation quiescence CSCs, its during stress. The further highlights autophagy-associated pathways could CSCs. Overall, present will help rationalize translational approaches involve autophagy-mediated controlling progression, metastasis,

Language: Английский

Cancer stem cells: advances in knowledge and implications for cancer therapy DOI Creative Commons

Xianjing Chu,

Wentao Tian,

Jiaoyang Ning

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 5, 2024

Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy treatment resistance still inevitable. Our review begins with brief introduction historical discoveries, original hypotheses, pathways regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, their crosstalk. We focus on role CSCs various therapeutic outcomes resistance, including how affect content alteration related molecules, CSCs-mediated clinical value targeting refractory, progressed or advanced tumors. summary, efficacy, method is difficult determine. Clarifying regulatory mechanisms biomarkers currently mainstream idea.

Language: Английский

Citations

85
Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy DOI Creative Commons

Qinmei Ma,

Jialin Yu,

Xu Zhang

et al.

Biochimie, Journal Year: 2023, Volume and Issue: 211, P. 57 - 67

Published: March 11, 2023

The Wnt/β-catenin signaling pathway is a highly conserved that involved in cell development, proliferation, differentiation, apoptosis and autophagy. Among these processes, autophagy occur physiologically during host defense the maintenance of intracellular homeostasis. Mounting evidence suggests crosstalk between Wnt/β-catenin-regulated has broad functional significance various diseases. Herein, we summarize recent studies understanding role autophagy, draw following conclusions: a) For apoptosis, regulation generally positive. However, small amount indicates presence negatively regulated relationship apoptosis; b) influences occurrence development by regulating autophagy-related factors, factors turn affect pathway; c) always balances molecular damage caused compensatory manner. Understanding specific different stages may provide new insights into progression related diseases pathway.

Language: Английский

Citations

44
Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines DOI Open Access
Jianli Chen, Xuan Wu, Dan Yin

et al.

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 249, P. 108485 - 108485

Published: July 3, 2023

Language: Английский

Citations

42
Complex roles of autophagy in cancer development, immune evasion, and drug resistance DOI

Xuegang Niu,

Qi Sheng You, Kejun Hou

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 78, P. 101170 - 101170

Published: Nov. 15, 2024

Language: Английский

Citations

17
SOX2 function in cancers: Association with growth, invasion, stemness and therapy response DOI Open Access

Sepideh Mirzaei,

Mahshid Deldar Abad Paskeh, Maliheh Entezari

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113860 - 113860

Published: Oct. 20, 2022

Language: Английский

Citations

41
Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathways DOI Open Access

Eisa Sabouni,

Melina Maghsodlou Nejad,

Sarah Mojtabavi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114395 - 114395

Published: Feb. 15, 2023

Colorectal cancer (CRC) is a dangerous form of that affects the gastrointestinal tract. It major global health concern, and aggressive behavior tumor cells makes it difficult to treat, leading poor survival rates for patients. One challenge in treating CRC metastasis, or spread, cancer, which cause death. In order improve prognosis patients with CRC, necessary focus on ways inhibit cancer's ability invade spread. Epithelial-mesenchymal transition (EMT) process linked spread cells, also known as metastasis. The transforms epithelial into mesenchymal ones, increasing their mobility other tissues. This has been shown be key mechanism progression colorectal (CRC), particularly cancer. activation EMT leads increases during this process, levels protein E-cadherin decrease while N-cadherin vimentin increase. contributes development resistance chemotherapy radiation therapy CRC. Non-coding RNAs, such long non-coding RNAs (lncRNAs) circular (circRNAs), play role regulating often through "sponge" microRNAs. Anti-cancer agents have suppress reduce cells. These findings suggest targeting related mechanisms may promising approach clinic.

Language: Английский

Citations

38
The Significance of Cancer Stem Cells and Epithelial–Mesenchymal Transition in Metastasis and Anti-Cancer Therapy DOI Open Access
Lili Liang, Andreas M. Kaufmann

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2555 - 2555

Published: Jan. 29, 2023

Cancer stem cells (CSCs) have been identified and characterized in both hematopoietic solid tumors. Their existence was first predicted by Virchow Cohnheim the 1870s. Later, many studies showed that CSCs can be isolated their expression of specific cell markers. The significance with respect to tumor biology anti-cancer treatment lies ability maintain quiescence very slow proliferation, indefinite self-renewal, differentiation, trans-differentiation such as epithelial-mesenchymal transition (EMT) its reverse process mesenchymal-epithelial (MET). for detachment, migration, extra- intravasation, invasion thereby completing all necessary steps metastatic cascade highlights metastasis. comprise cancer populations responsible growth, resistance therapies In this review, history CSC theory, identification characterization are described. contribution undergo EMT metastasis is discussed. Recently, novel strategies drug development focused on elimination specifically. unique functional molecular properties discussed possible therapeutic vulnerabilities anti-metastasis treatments. Prospectively, may provide precise personalized treatments improved efficiency fewer side effects leading better prognosis.

Language: Английский

Citations

33
Transcriptional regulation of autophagy and its implications in human disease DOI
Yuchen Lei, Daniel J. Klionsky

Cell Death and Differentiation, Journal Year: 2023, Volume and Issue: 30(6), P. 1416 - 1429

Published: April 12, 2023

Language: Английский

Citations

33
Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer DOI Creative Commons
Zhengguang Li, Zhirong Yang, Wei Liu

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 5, 2023

Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis drug-resistance. Disheveled3 (DVL3) is involved malignant behaviors of cancer. However, the potential mechanism DVL3 remain elusive EMT CSLCs colorectal (CRC).

Language: Английский

Citations

31
Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways DOI Open Access

Maya R. MacLean,

Olivia L. Walker, Raj Pranap Arun

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4102 - 4102

Published: April 7, 2024

Cancer stem cells (CSCs) represent a subpopulation within tumors that promote cancer progression, metastasis, and recurrence due to their self-renewal capacity resistance conventional therapies. CSC-specific markers signaling pathways highly active in CSCs have emerged as promising strategy for improving patient outcomes. This review provides comprehensive overview of the therapeutic targets associated with solid across various types, including key molecular aldehyde dehydrogenases, CD44, epithelial cellular adhesion molecule, CD133 such Wnt/β-catenin, Notch, Sonic Hedgehog. We discuss wide array modalities ranging from targeted antibodies, small molecule inhibitors, near-infrared photoimmunotherapy advanced genetic approaches like RNA interference, CRISPR/Cas9 technology, aptamers, antisense oligonucleotides, chimeric antigen receptor (CAR) T cells, CAR natural killer bispecific cell engagers, immunotoxins, drug-antibody conjugates, peptides, dendritic vaccines. spans developments preclinical investigations ongoing clinical trials, highlighting innovative targeting strategies been informed by CSC-associated molecules overcome resistance. aim provide insights into potential these therapies revolutionize treatment, underscoring critical need multi-faceted approach battle against cancer. analysis demonstrates how advances made CSC field significant novel approaches, ultimate goal achieving more effective durable responses patients.

Language: Английский

Citations

15