Cell
death
is
one
of
the
most
important
mechanisms
maintaining
homeostasis
in
our
body.
Ferroptosis
and
pyroptosis
are
forms
necrosis-like
cell
death.
These
modalities
play
key
roles
pathophysiology
cancer,
cardiovascular,
neurological
diseases,
other
pathologies.
Transition
metals
abundant
group
elements
all
living
organisms.
This
paper
presents
a
summary
ferroptosis
pathways
their
connection
to
significant
transition
metals,
namely
zinc
(Zn),
copper
(Cu),
molybdenum
(Mo),
lead
(Pb),
cobalt
(Co),
iron
(Fe),
cadmium
(Cd),
nickel
(Ni),
mercury
(Hg),
uranium
(U),
platinum
(Pt),
crucial
element,
selenium
(Se).
Authors
aim
summarize
up-to-date
knowledge
this
topic.In
review,
there
categorized
highlighted
common
patterns
alterations
by
metals.
Special
attention
given
since
collected
data
support
its
dual
nature
action
both
pyroptosis.
All
findings
presented
together
with
brief
description
major
biochemical
involving
mentioned
visualized
attached
comprehensive
figures.This
work
concludes
that
majority
disruptions
studied
metals'
impacts
fate,
influencing
survival
cells
complex
system
altered
pathways.
Therefore,
opens
up
space
for
further
research.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 325 - 325
Опубликована: Фев. 26, 2025
The
emergence
of
nanotechnology
in
medicine,
particularly
using
iron
oxide
nanoparticles
(IONPs),
may
impact
cancer
treatment
strategies.
IONPs
exhibit
unique
properties,
such
as
superparamagnetism,
biocompatibility,
and
ease
surface
modification,
making
them
ideal
candidates
for
imaging,
therapeutic
interventions.
Their
application
targeted
drug
delivery,
especially
with
traditional
chemotherapeutic
agents
like
cisplatin,
has
shown
potential
overcoming
limitations
low
bioavailability
systemic
toxicity
chemotherapies.
Moreover,
IONPs,
by
releasing
ions,
can
induce
ferroptosis,
a
form
iron-dependent
cell
death,
which
offers
promising
pathway
to
reverse
radio-
chemoresistance
therapy.
In
particular,
demonstrate
significant
radiosensitisers,
enhancing
the
effects
radiotherapy
promoting
reactive
oxygen
species
(ROS)
generation,
lipid
peroxidation,
modulating
tumour
microenvironment
stimulate
antitumour
immune
responses.
This
review
explores
multifunctional
roles
radiosensitisation
through
ferroptosis
induction,
highlighting
their
promise
advancing
head
neck
cancers.
Additional
research
is
crucial
fully
addressing
clinical
settings,
offering
novel
approach
personalised
treatment.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 10, 2024
Ferroptosis
is
an
iron-dependent
form
of
regulated
cell
death
characterized
by
glutathione
(GSH)
depletion,
peroxidase
4
(GPX4)
inactivation,
and
the
build-up
lipotoxic
reactive
species.
Ferroptosis-targeted
induction
a
promising
therapeutic
approach
for
addressing
antimalarial
drug
resistance.
In
addition
to
being
primary
source
intracellular
energy
supply
oxygen
species
(ROS)
generation,
mitochondria
actively
participate
in
diverse
forms
death,
including
ferroptosis.
Altered
mitochondrial
morphology
functionality
are
attributed
Diverse
mitochondria-related
proteins
metabolic
activities
have
been
implicated
fine-tuning
action
ferroptosis
inducers.
Herein,
we
review
recent
progress
this
evolving
field,
elucidating
numerous
mechanisms
which
regulate
giving
insight
into
role
organelle
Additionally,
present
overview
how
contribute
malaria.
Furthermore,
attempt
shed
light
on
inclusive
perspective
targeting
malaria
parasites'
mitochondrion
attacking
redox
homeostasis
anticipated
induce
ferroptosis-mediated
antiparasitic
effects.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 8, 2024
Neurodegenerative
diseases
represent
a
pressing
global
health
challenge,
and
the
identification
of
novel
mechanisms
underlying
their
pathogenesis
is
utmost
importance.
Ferroptosis,
non-apoptotic
form
regulated
cell
death
characterized
by
iron-dependent
lipid
peroxidation,
has
emerged
as
pivotal
player
in
neurodegenerative
diseases.
This
review
delves
into
discovery
ferroptosis,
critical
players
involved,
intricate
role
neurodegeneration,
with
an
emphasis
on
Alzheimer’s
Parkinson’s
We
critically
appraise
unsolved
mechanistic
links
involved
initiation
propagation
such
signaling
cascade
resulting
de-repression
lipoxygenase
translation
played
mitochondrial
voltage-dependent
anionic
channels
iron
homeostasis.
Particular
attention
given
to
dual
heme
oxygenase
which
may
be
linked
non-specific
activity
P450
reductase
endoplasmic
reticulum.
Despite
limited
knowledge
ferroptosis
progression
Nrf2/Bach1
target
genes
have
crucial
defenders
anti-ferroptotic
pathways.
The
activation
Nrf2
inhibition
Bach1
can
counteract
present
promising
avenue
for
future
therapeutic
interventions
targeting
Cell
death
is
one
of
the
most
important
mechanisms
maintaining
homeostasis
in
our
body.
Ferroptosis
and
pyroptosis
are
forms
necrosis-like
cell
death.
These
modalities
play
key
roles
pathophysiology
cancer,
cardiovascular,
neurological
diseases,
other
pathologies.
Transition
metals
abundant
group
elements
all
living
organisms.
This
paper
presents
a
summary
ferroptosis
pathways
their
connection
to
significant
transition
metals,
namely
zinc
(Zn),
copper
(Cu),
molybdenum
(Mo),
lead
(Pb),
cobalt
(Co),
iron
(Fe),
cadmium
(Cd),
nickel
(Ni),
mercury
(Hg),
uranium
(U),
platinum
(Pt),
crucial
element,
selenium
(Se).
Authors
aim
summarize
up-to-date
knowledge
this
topic.In
review,
there
categorized
highlighted
common
patterns
alterations
by
metals.
Special
attention
given
since
collected
data
support
its
dual
nature
action
both
pyroptosis.
All
findings
presented
together
with
brief
description
major
biochemical
involving
mentioned
visualized
attached
comprehensive
figures.This
work
concludes
that
majority
disruptions
studied
metals'
impacts
fate,
influencing
survival
cells
complex
system
altered
pathways.
Therefore,
opens
up
space
for
further
research.
