Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: April 10, 2024

Ferroptosis is an iron-dependent form of regulated cell death characterized by glutathione (GSH) depletion, peroxidase 4 (GPX4) inactivation, and the build-up lipotoxic reactive species. Ferroptosis-targeted induction a promising therapeutic approach for addressing antimalarial drug resistance. In addition to being primary source intracellular energy supply oxygen species (ROS) generation, mitochondria actively participate in diverse forms death, including ferroptosis. Altered mitochondrial morphology functionality are attributed Diverse mitochondria-related proteins metabolic activities have been implicated fine-tuning action ferroptosis inducers. Herein, we review recent progress this evolving field, elucidating numerous mechanisms which regulate giving insight into role organelle Additionally, present overview how contribute malaria. Furthermore, attempt shed light on inclusive perspective targeting malaria parasites' mitochondrion attacking redox homeostasis anticipated induce ferroptosis-mediated antiparasitic effects.

Language: Английский

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Acteoside alleviates lipid peroxidation by enhancing Nrf2-mediated mitophagy to inhibit ferroptosis for neuroprotection in Parkinson's disease

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 493 - 505

Published: July 24, 2024

Language: Английский

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The interplay of transition metals in ferroptosis and pyroptosis

Cell Division, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 3, 2024

Cell death is one of the most important mechanisms maintaining homeostasis in our body. Ferroptosis and pyroptosis are forms necrosis-like cell death. These modalities play key roles pathophysiology cancer, cardiovascular, neurological diseases, other pathologies. Transition metals abundant group elements all living organisms. This paper presents a summary ferroptosis pathways their connection to significant transition metals, namely zinc (Zn), copper (Cu), molybdenum (Mo), lead (Pb), cobalt (Co), iron (Fe), cadmium (Cd), nickel (Ni), mercury (Hg), uranium (U), platinum (Pt), crucial element, selenium (Se). Authors aim summarize up-to-date knowledge this topic.In review, there categorized highlighted common patterns alterations by metals. Special attention given since collected data support its dual nature action both pyroptosis. All findings presented together with brief description major biochemical involving mentioned visualized attached comprehensive figures.This work concludes that majority disruptions studied metals' impacts fate, influencing survival cells complex system altered pathways. Therefore, opens up space for further research.

Language: Английский

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Gut microbiota in health and disease: advances and future prospects

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

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A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(4), P. 815 - 833

Published: Jan. 3, 2024

Language: Английский

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