Unraveling the tumor microenvironment: Insights into cancer metastasis and therapeutic strategies

Cancer Letters, Год журнала: 2024, Номер 591, С. 216894 - 216894

Опубликована: Апрель 16, 2024

This comprehensive review delves into the pivotal role of tumor microenvironment (TME) in cancer metastasis and therapeutic response, offering fresh insights intricate interplay between cells their surrounding milieu. The TME, a dynamic ecosystem comprising diverse cellular acellular elements, not only fosters progression but also profoundly affects efficacy conventional emerging therapies. Through nuanced exploration, this illuminates multifaceted nature elucidating its capacity to engender drug resistance via mechanisms such as hypoxia, immune evasion, establishment physical barriers delivery. Moreover, it investigates innovative approaches aimed at targeting including stromal reprogramming, modulation, extracellular matrix (ECM)-targeting agents, personalized medicine strategies, highlighting potential augment treatment outcomes. Furthermore, critically evaluates challenges posed by complexity heterogeneity which contribute variable responses potentially unintended consequences. underscores need identify robust biomarkers advance predictive models anticipate outcomes, well advocate for combination therapies that address multiple facets TME. Finally, emphasizes necessity an interdisciplinary approach integration cutting-edge technologies unravel intricacies thereby facilitating development more effective, adaptable, treatments. By providing critical current state TME research implications future oncology, highlights evolving landscape field.

Язык: Английский

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Hallmarks of cancer resistance

iScience, Год журнала: 2024, Номер 27(6), С. 109979 - 109979

Опубликована: Май 15, 2024

This review explores the hallmarks of cancer resistance, including drug efflux mediated by ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized Warburg effect, and dynamic interplay between cells mitochondria. The role stem (CSCs) in treatment resistance regulatory influence non-coding RNAs, such as long RNAs (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are studied. chapter emphasizes future directions, encompassing advancements immunotherapy, strategies to counter adaptive integration artificial intelligence for predictive modeling, identification biomarkers personalized treatment. comprehensive exploration these provides a foundation innovative therapeutic approaches, aiming navigate complex landscape enhance patient outcomes.

Язык: Английский

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Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects

Journal of Biomedical Science, Год журнала: 2025, Номер 32(1)

Опубликована: Янв. 9, 2025

Abstract Research into cancer treatment has been mainly focused on developing therapies to directly target cells. Over the past decade, extensive studies have revealed critical roles of tumour microenvironment (TME) in initiation, progression, and drug resistance. Notably, cancer-associated fibroblasts (CAFs) emerged as one primary contributors shaping TME, creating a favourable environment for development. Many preclinical identified promising targets CAFs, demonstrating remarkable efficacy some CAF-targeted treatments models. Encouraged by these compelling findings, therapeutic strategies now advanced clinical evaluation. We aim provide comprehensive review relevant subjects including CAF-related markers targets, their multifaceted roles, current landscape ongoing trials. This knowledge can guide future research CAFs advocate investigations targeting CAFs.

Язык: Английский

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Targeting cancer and immune cell metabolism with the complex I inhibitors metformin and IACS‐010759

Molecular Oncology, Год журнала: 2024, Номер 18(7), С. 1719 - 1738

Опубликована: Янв. 12, 2024

Metformin and IACS‐010759 are two distinct antimetabolic agents. Metformin, an established antidiabetic drug, mildly inhibits mitochondrial complex I, while is a new potent I inhibitor. Mitochondria pivotal in the energy metabolism of cells by providing adenosine triphosphate through oxidative phosphorylation (OXPHOS). Hence, OXPHOS become vulnerability when targeted cancer cells. Both drugs have promising antitumoral effects diverse cancers, supported preclinical vitro vivo studies. We present evidence their direct impact on immunomodulatory effects. In clinical studies, observational epidemiologic studies metformin were encouraging, actual trial results not as expected. However, IACS‐01075 exhibited major adverse effects, thereby causing metabolic shift to glycolysis elevated lactic acid concentrations. Therefore, future outlook for these depends preventive trials investigations into plausible toxic normal IACS‐01075.

Язык: Английский

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Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy

Cytokine & Growth Factor Reviews, Год журнала: 2024, Номер 76, С. 12 - 21

Опубликована: Фев. 28, 2024

Язык: Английский

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Enhancing cancer immunotherapy with photodynamic therapy and nanoparticle: making tumor microenvironment hotter to make immunotherapeutic work better

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 5, 2024

Cancer immunotherapy has made tremendous advancements in treating various malignancies. The biggest hurdle to successful would be the immunosuppressive tumor microenvironment (TME) and low immunogenicity of cancer cells. To make successful, ‘cold’ TME must converted ‘hot’ immunostimulatory status activate residual host immune responses. this end, equilibrium should broken, immunogenic cell death ought induced stimulate tumor-killing cells appropriately. Photodynamic therapy (PDT) is an efficient way inducing (ICD) disrupting immune-restrictive tissues. PDT trigger a chain reaction that have ICD-induced antigens presented In principle, strategic combination synergize enhance therapeutic outcomes many intractable tumors. Novel technologies employing nanocarriers were developed deliver photosensitizers immunotherapeutic efficiently. New-generation nanomedicines been for recent years, which will accelerate clinical applications.

Язык: Английский

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The follicular lymphoma tumor microenvironment at single-cell and spatial resolution

Blood, Год журнала: 2024, Номер 143(12), С. 1069 - 1079

Опубликована: Янв. 9, 2024

Язык: Английский

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Dual Roles of miR-10a-5p and miR-10b-5p as Tumor Suppressors and Oncogenes in Diverse Cancers

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 415 - 415

Опубликована: Янв. 6, 2025

Cancer is a complex genetic disorder characterized by abnormalities in both coding and regulatory non-coding RNAs. microRNAs (miRNAs) are key RNAs that modulate cancer development, functioning as tumor suppressors oncogenes. miRNAs play critical roles progression, influencing processes such initiation, promotion, metastasis. They exert their effects targeting suppressor genes, thereby facilitating while also inhibiting oncogenes to prevent further disease advancement. The miR-10 family, particularly miR-10a-5p miR-10b-5p (miR-10a/b-5p), notably involved progression. Intriguingly, functions can differ across different cancers, sometimes promoting at other times suppressing growth depending on the type target genes. This review explores dual of miR-10a/b-5p tumor-suppressive (TSmiRs) or oncogenic (oncomiRs) various cancers examining molecular cellular mechanisms impact microenvironment. Furthermore, we discuss potential therapeutic targets, emphasizing miRNA-based strategies for treatment. insights discussed this aim advance our understanding miR-10a/b-5p’s biology application developing innovative therapies.

Язык: Английский

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Exercise-induced extracellular vesicles in reprogramming energy metabolism in cancer

Frontiers in Oncology, Год журнала: 2025, Номер 14

Опубликована: Янв. 6, 2025

Cancer is caused by complex interactions between genetic, environmental, and lifestyle factors, making prevention strategies, including exercise, a promising avenue for intervention. Physical activity associated with reduced cancer incidence progression systemic anti-cancer effects, improved tumor suppression prolonged survival in preclinical models. Exercise impacts the body's nutrient balance stimulates release of several exercise-induced factors into circulation. The mechanisms how exercise modulates energy metabolism microenvironment through effects mediated, part, extracellular vesicles (EVs) are still unknown. By transferring bioactive cargo such as miRNAs, proteins metabolites, EVs may influence cells altering glycolysis oxidative phosphorylation, potentially shifting metabolic plasticity - hallmark cancer. This short review explores roles mediators to reprogram cellular exchanging information inside microenvironment, influencing immune cells, fibroblast distant cells. Considering this knowledge, further functional studies production pathways could inform more specific interventions enhance therapy improve patient outcomes.

Язык: Английский

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Tokay gecko tail regeneration involves temporally collinear expression of HOXC genes and early expression of satellite cell markers

BMC Biology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 8, 2025

Regeneration is the replacement of lost or damaged tissue with a functional copy. In axolotls and zebrafish, regeneration involves stem cells produced by de-differentiation. These form growth zone which expresses developmental patterning genes at its apex. This system resembles an embryonic field where undergo pattern formation. Some lizards, including geckos, can regenerate their tails, but it unclear whether they show "development-like" pathway. Using tokay gecko (Gekko gecko) model species, we examined seven stages tail regeneration, three bud development, using transcriptomics, single-cell sequencing, in situ hybridization. We find no apical regenerating tail. The transcriptomes vs. tails are quite different respect to genes. Posterior HOXC were activated temporally collinear sequence major precursor populations stromal (regenerating tail) pluripotent (embryonic tail). Segmented skeletal muscles regenerated expression classical segmentation genes, early activation satellite cell markers. Our study suggests that gecko—unlike development—might rely on resident cells, guided pre-existing positional information.

Язык: Английский

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