The complexities of cell death mechanisms: a new perspective in systemic sclerosis therapy
APOPTOSIS,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 9, 2025
Язык: Английский
Uteroplacental microvascular remodeling in health and disease
Acta Physiologica,
Год журнала:
2025,
Номер
241(5)
Опубликована: Март 29, 2025
The
microvascular
system
is
essential
for
delivering
oxygen
and
nutrients
to
tissues
while
removing
metabolic
waste.
During
pregnancy,
the
uteroplacental
undergoes
extensive
remodeling
meet
increased
demands
of
fetus.
Key
adaptations
include
vessel
dilation
increases
in
vascular
volume,
density,
permeability,
all
which
ensure
adequate
placental
perfusion
maintaining
stable
maternal
blood
pressure.
Structural
functional
abnormalities
microvasculature
are
associated
with
various
gestational
complications,
posing
both
immediate
long-term
risks
health
mother
infant.
In
this
review,
we
describe
changes
microvessels
during
discuss
pathogenic
mechanisms
underlying
diseases
such
as
preeclampsia,
fetal
growth
restriction,
diabetes,
summarize
current
clinical
research
approaches
monitoring
health.
We
also
provide
an
update
on
models
complications
explore
solutions
several
unresolved
challenges.
With
advancements
techniques,
anticipate
significant
progress
understanding
managing
these
diseases,
ultimately
leading
new
therapeutic
strategies
improve
Язык: Английский
Impact of Ionizing Radiation Exposure on Placental Function and Implications for Fetal Programming
Cameron Hourtovenko,
Shayen Sreetharan,
Sujeenthar Tharmalingam
и другие.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9862 - 9862
Опубликована: Сен. 12, 2024
Accidental
exposure
to
high-dose
radiation
while
pregnant
has
shown
significant
negative
effects
on
the
developing
fetus.
One
fetal
organ
which
been
studied
is
placenta.
The
placenta
performs
all
essential
functions
for
development,
including
nutrition,
respiration,
waste
excretion,
endocrine
communication,
and
immunological
functions.
Improper
placental
development
can
lead
complications
during
pregnancy,
as
well
occurrence
of
intrauterine
growth-restricted
(IUGR)
offspring.
IUGR
one
leading
indicators
programming,
classified
an
improper
uterine
environment
predisposition
diseases
within
With
numerous
studies
examining
there
remains
a
gap
in
understanding
placenta's
role
irradiation-induced
programming.
This
review
aims
synthesize
current
knowledge
how
irradiation
affects
function
guide
future
research
directions.
provides
comprehensive
overview
biology,
its
structure,
function,
summarizes
with
focus
impact
biology.
Taken
together,
this
demonstrates
that
causes
degradation
immune
dysregulation.
Given
crucial
essential.
Язык: Английский
Alloimmune Causes of Recurrent Pregnancy Loss: Cellular Mechanisms and Overview of Therapeutic Approaches
Medicina,
Год журнала:
2024,
Номер
60(11), С. 1896 - 1896
Опубликована: Ноя. 19, 2024
Recurrent
pregnancy
loss
(RPL)
is
a
complex
early
complication
affecting
1-2%
of
couples
and
often
linked
to
immune
dysfunction.
Aberrations
in
T
B
cell
subpopulations,
as
well
natural
killer
(NK)
activity,
are
particularly
influential,
with
studies
showing
that
abnormal
NK
activation
imbalances
subtypes
contribute
immune-mediated
miscarriage
risk.
Successful
requires
tightly
regulated
balance
between
pro-inflammatory
anti-inflammatory
responses.
In
the
stages,
inflammation
supports
processes
such
trophoblast
invasion
spiral
artery
remodeling,
but
this
must
be
tempered
prevent
rejection
fetus.
review,
we
explore
underlying
mechanisms
RPL,
focusing
on
how
dysregulated
T,
B,
function
disrupts
maternal
tolerance.
Specifically,
discuss
essential
role
uterine
cells
stages
vascular
remodeling
decidua
regulate
depth
by
extravillous
trophoblasts.
Furthermore,
focus
delicate
Treg
dynamics
enable
maintenance
optimal
homeostasis,
where
balance,
not
only
quantity
Tregs,
crucial
for
fostering
maternal-fetal
Other
Th1,
Th2,
Th17
cells,
also
imbalance,
Th1
promoting
potentially
harming
fetal
tolerance,
while
Th2
support
Finally,
show
changes
subpopulations
their
functions
have
been
associated
adverse
outcomes.
We
further
current
therapeutic
strategies
aimed
at
correcting
these
imbalances,
including
intravenous
immunoglobulin
(IVIg),
glucocorticoids,
TNF-α
inhibitors,
examining
efficacy,
challenges,
potential
side
effects.
By
highlighting
both
benefits
limitations
interventions,
aim
offer
balanced
perspective
clinical
applications
women
facing
immune-related
causes
RPL.
Язык: Английский
Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders
Cytokine & Growth Factor Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Apoptotic and non-apoptotic roles of caspases in placenta physiology and pathology
Placenta,
Год журнала:
2024,
Номер
151, С. 37 - 47
Опубликована: Март 30, 2024
Caspases,
a
family
of
cysteine
proteases,
are
pivotal
regulators
apoptosis,
the
tightly
controlled
cell
death
process
crucial
for
eliminating
excessive
or
unnecessary
cells
during
development,
including
placental
development.
Collecting
research
has
unveiled
multifaceted
roles
caspases
in
placenta,
extending
beyond
apoptosis.
Apart
from
their
involvement
tissue
remodeling
via
actively
participate
essential
regulatory
processes,
such
as
trophoblast
fusion
and
differentiation,
significantly
influencing
growth
functionality.
In
addition,
growing
evidence
indicates
an
elevation
caspase
activity
under
pathological
conditions
like
pre-eclampsia
(PE)
intrauterine
restriction
(IUGR),
leading
to
well
inflammation.
Drawing
advancements
development
both
normal
abnormal
conditions,
we
examine
significance
(apoptosis)
non-cell
death-related
processes
within
placenta.
We
also
discuss
potential
therapeutics
targeting
caspase-related
pathways
placenta
disorders.
Язык: Английский
Impacts of tolylfluanid on implantation and placental development: Disruption of mitochondrial function and implantation-related gene expression in vitro and in vivo
The Science of The Total Environment,
Год журнала:
2024,
Номер
951, С. 175549 - 175549
Опубликована: Авг. 14, 2024
Язык: Английский
Genomic Regions Associated with Spontaneous Abortion in Holstein Heifers
Genes,
Год журнала:
2024,
Номер
15(12), С. 1498 - 1498
Опубликована: Ноя. 22, 2024
Background/Objectives:
The
dairy
industry
relies
on
reproductive
efficiency
to
maintain
efficient
milk
production.
Spontaneous
abortion
(SA),
defined
as
pregnancy
loss
between
gestation
days
42
and
260,
occurred
in
4.5%
of
the
artificially
inseminated
(AI)
Holstein
heifers
31.6%
embryo
transfer
(ET)
recipient
that
received
vitro-produced
frozen
embryos
a
single
farm
Idaho.
Methods:
A
genome-wide
association
analysis
(GWAA)
was
performed
identify
associations
(FDR
p
<
0.05)
with
SA
were
bred
by
AI
(1351
controls
delivered
at
term
63
cases
aborted)
conceived
following
first
insemination,
well
59
273
ET
pregnant
from
ET.
Results:
There
216
loci
413
positional
candidate
genes
associated
recessive
model
no
recipients.
Conclusions:
identification
may
be
used
reduce
fetal
through
genomic
selection.
Язык: Английский