Recent Innovations in Bacterial Infection Detection and Treatment

ACS Infectious Diseases, Год журнала: 2021, Номер 7(4), С. 695 - 720

Опубликована: Март 18, 2021

Bacterial infections are a major threat to human health, exacerbated by increasing antibiotic resistance. These can result in tremendous morbidity and mortality, emphasizing the need identify treat pathogenic bacteria quickly effectively. Recent developments detection methods have focused on electrochemical, optical, mass-based biosensors. Advances these systems include implementing multifunctional materials, microfluidic sampling, portable data-processing improve sensitivity, specificity, ease of operation. Concurrently, advances antibacterial treatment largely targeted responsive delivery for both antibiotics alternatives. Antibiotic alternatives described here repurposed drugs, antimicrobial peptides polymers, nucleic acids, small molecules, living systems, bacteriophages. Finally, closed-loop therapies combining fields treatment. This review provides comprehensive summary current trends bacterial infections.

Язык: Английский

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Mesenchymal Stem Cell‐Derived Extracellular Vesicles with High PD‐L1 Expression for Autoimmune Diseases Treatment

Advanced Materials, Год журнала: 2021, Номер 34(1)

Опубликована: Окт. 8, 2021

Autoimmune diseases are the third most common disease influencing quality of life many patients. Here, a programmed cell death-ligand 1 + (PD-L1) mesenchymal stem (MSC) derived extracellular vesicles (MSC-sEVs-PD-L1) using lentivirus-mediated gene transfection technology is developed for reconfiguration local immune microenvironment affected tissue in autoimmune diseases. MSC-sEVs-PD-L1 exhibits an impressive ability to regulate various activated cells immunosuppressed state vitro. More importantly, dextran sulfate sodium-induced ulcerative colitis (UC) and imiquimod-induced psoriasis mouse models, significantly high accumulation observed inflamed tissues compared PD-L1+ MSCs. Therapeutic efficiency both UC models demonstrated reshape inflammatory ecosystem context. A as natural delivery platform treatment with clinical potential.

Язык: Английский

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Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Май 13, 2021

Plants have been extensively studied since ancient times and numerous important chemical constituents with tremendous therapeutic potential are identified. Attacks of microorganisms including viruses bacteria can be counteracted an efficient immune system therefore, stimulation body's defense mechanism against infections has proven to effective approach. Polysaccharides, terpenoids, flavonoids, alkaloids, glycosides, lactones the phytochemicals, reported primarily responsible for immunomodulation activity plants. These phytochemicals may act as lead molecules development safe immunomodulators remedies prevention cure viral diseases. Natural products known modulate in nonspecific ways. A number plant-based principles identified isolated which justify their use traditional folklore medicine form basis further specified research. The aim current review is describe highlight certain plants along bioactive constituents. Relevant literatures recent years were searched from commonly employed scientific databases on ethnopharmacological use. Most displaying considerable summarized possible mechanisms. discussions shall hopefully elicit attention researchers encourage studies these therapy management infectious diseases, ones such COVID-19.

Язык: Английский

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A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging

Phytomedicine, Год журнала: 2023, Номер 115, С. 154824 - 154824

Опубликована: Апрель 19, 2023

Every day the skin is constantly exposed to several harmful factors that induce oxidative stress. When cells are incapable maintain balance between antioxidant defenses and reactive oxygen species, no longer can keep its integrity homeostasis. Chronic inflammation, premature aging, tissue damage, immunosuppression possible consequences induced by sustained exposure environmental endogenous species. Skin immune non-immune together with microbiome essential efficiently trigger responses For this reason, an ever-increasing demand for novel molecules capable of modulating functions in has risen level their development, particularly field natural product-derived molecules. In review, we explore different classes showed evidence modulate responses, as well target receptors signaling pathways. Moreover, describe role polyphenols, polysaccharides, fatty acids, peptides, probiotics treatments conditions, including wound healing, infection, allergies, aging. Literature was searched, analyzed, collected using databases, PubMed, Science Direct, Google Scholar. The search terms used included "Skin", "wound healing", "natural products", "skin microbiome", "immunomodulation", "anti-inflammatory", "antioxidant", "infection", "UV radiation", "polyphenols", "polysaccharides", "fatty acids", "plant oils", "peptides", "antimicrobial peptides", "probiotics", "atopic dermatitis", "psoriasis", "auto-immunity", "dry skin", "aging", etc., combinations these keywords. Natural products offer solutions conditions. Significant anti-inflammatory activities were reported, followed ability skin. Several membrane-bound recognize diverse types natural-derived molecules, promoting improve Despite increasing progress drug discovery, limiting need future clarification. Understanding safety, biological activities, precise mechanisms action a priority characterization active compounds responsible that. This review provides directions studies development new important pharmaceutical cosmeceutical value.

Язык: Английский

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The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy

Cellular and Molecular Immunology, Год журнала: 2022, Номер 19(2), С. 192 - 209

Опубликована: Янв. 4, 2022

Язык: Английский

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Язык: Английский

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Dual-Responsive Nanomedicine Activates Programmed Antitumor Immunity through Targeting Lymphatic System

ACS Nano, Год журнала: 2024, Номер 18(17), С. 11070 - 11083

Опубликована: Апрель 19, 2024

Effective antitumor immunotherapy depends on evoking a cascade of cancer-immune cycles with lymph nodes (LNs) as the initial sites for activating immunity, making drug administration through lymphatic system highly attractive. Here, we describe nanomedicine dual responsiveness to pH and enzyme programmed activation immune system. The proposed can release STING agonist diABZI-C2-NH2 in LNs' acidic environment activate dendritic cells (DCs) T cells. Then, remaining hitchhikes activated (PD-1+ cells) binding PD-1, resulting an effective delivery into tumor tissues owing tumor-homing capacity PD-1+ matrix metalloproteinase-2 (MMP-2) being enriched tissue triggers PD-1 antibody (aPD-1) which exerts checkpoint blockade (ICB) therapy. Eventually, delivers DNA methylation inhibitor GSK-3484862 (GSK) cells, then latter combines granzyme B (GZMB) trigger cell pyroptosis. Consequently, pyroptotic induce robust immunogenic death (ICD) enhancing DCs maturation initiating cascading response. Study 4T1 breast mouse model demonstrates prominent therapeutic outcome this creating positive feedback loop cancer-immunity including LNs, cell-mediated delivery, ICB therapy, pyroptosis-featured ICD.

Язык: Английский

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Helicobacter pylori and gastric cancer: current insights and nanoparticle-based interventions

RSC Advances, Год журнала: 2025, Номер 15(7), С. 5558 - 5570

Опубликована: Янв. 1, 2025

Background: H. pylori is recognized as one of the main causes gastric cancer, and this type cancer considered leading diseases causing deaths all over world.

Язык: Английский

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Nanobody: A Small Antibody with Big Implications for Tumor Therapeutic Strategy

International Journal of Nanomedicine, Год журнала: 2021, Номер Volume 16, С. 2337 - 2356

Опубликована: Март 1, 2021

Abstract: The development of monoclonal antibody treatments for successful tumor-targeted therapies took several decades. However, the efficacy antibody-based therapy is still confined and desperately needs further improvement. Nanobodies are recombinant variable domains heavy-chain-only antibodies, with many unique properties such as small size (∼ 15kDa), excellent solubility, superior stability, ease manufacture, quick clearance from blood, deep tissue penetration, which gain increasing acceptance therapeutical tools considered also building blocks chimeric antigen receptors well targeted drug delivery. Thus, one promising novel developments that may address deficiency utilization nanobodies. This article provides readers significant factors structural biochemical nanobodies research progress on in fields tumor treatment, their application prospect. Keywords: nanobody, delivery, immunotherapy, CAR-T, treatment

Язык: Английский

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Bacteriocins: Potential for Human Health

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Due to the challenges of antibiotic resistance global health, bacteriocins as antimicrobial compounds have received more and attention. Bacteriocins are biosynthesized by various microbes predominantly used food preservatives control foodborne pathogens. Now, increasing researches focused on potential clinical antimicrobials or immune‐modulating agents fight against threat human health. Given broad‐ narrow‐spectrum activity, been reported inhibit a wide range clinically pathogenic multidrug‐resistant bacteria, thus preventing infections caused these bacteria in body. Otherwise, some also show anticancer, anti‐inflammatory, immune‐modulatory activities. Because safety being not easy cause drug resistance, appear better efficacy application prospects than existing therapeutic do. In this review, we highlight activities suggest opportunities for their application.

Язык: Английский

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