Free Radical Biology and Medicine, Год журнала: 2024, Номер 222, С. 106 - 121
Опубликована: Май 24, 2024
Severe dry eye disease causes ocular surface damage, which is highly associated with mitochondrial dysfunction. Mitochondrial transcription factor A (TFAM) essential for packaging DNA (mtDNA) and crucial maintaining function. Herein, we aimed to explore the effect of a decreased TFAM expression on damage.
Язык: Английский
Trends in Immunology, Год журнала: 2024, Номер 45(4), С. 248 - 258
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
11
Cells, Год журнала: 2024, Номер 13(17), С. 1413 - 1413
Опубликована: Авг. 24, 2024
The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia anomalies. Importantly, it associated with chronic pathologies (often age-related) that have inflammatory component. This includes atherosclerosis, diabetes Alzheimer's disease. Its mode of action these diseases not well understood, but inhibits or regulates multiple major pathways. has a membrane form soluble (s-Klotho). Cytosolic postulated characterized. s-Klotho endocrine properties are incompletely elucidated. binds to FGF receptor 1c (FGFR1c) widely expressed (including endothelial cells). also attaches FGF23, FGF23/Klotho FGFRs. Thus, might be roaming FGF23 coreceptor, functions. Notably, (cell-bound soluble) counteracts inflammation appears mitigate related aging (inflammaging). NF-κB NLRP3 inflammasome. inflammasome requires priming by produces active IL-1β, pores cell death (pyroptosis). In accord, countered injury induced toxins, damage-associated molecular patterns (DAMPs), cytokines, reactive oxygen species (ROS). blocks TGF-β Wnt ligands, which lessens fibrotic Low loss muscle mass (sarcopenia), as occurs diseases. counters inhibitory effects myostatin on muscle, reduces inflammation, improves repair following injury. inhibition factors may protective diabetic retinopathy age-related macular degeneration (AMD). review examines functions especially potential applications.
Язык: Английский
Процитировано
8
Frontiers in Molecular Neuroscience, Год журнала: 2025, Номер 17
Опубликована: Янв. 8, 2025
PANoptosis is a novelly defined mode of programmed cell death that involves the activation multiple cellular pathways, including pyroptosis, apoptosis, and necroptosis, triggering robust inflammatory reactions. Autophagy crucial process maintains homeostasis protects cells from various stresses. autophagy, both vital players in intricate pathological progression ischemic stroke (IS), brain ailment governed by cascades, have garnered attention recent years for their potential interplay. While mounting evidence hints at crosstalk between these two processes IS, underlying mechanisms remain elusive. Therefore, this review delves into dissects underpin intersection autophagy devastating condition. In conclusion, IS presents promising target development novel therapies. Understanding interplay pathways offers much-needed insight opens possibility new therapeutic strategies.
Язык: Английский
Процитировано
1
APOPTOSIS, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2025, Номер 15(4), С. 511 - 511
Опубликована: Апрель 1, 2025
Probenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion the kidney, affecting both endogenous substances like uric acid and exogenous ones penicillin. Beyond its renal applications, probenecid shown capabilities crossing blood–brain barrier modulating activity of various membrane channels transporters. This compound emerged as potent antiviral agent, demonstrating efficacy against multiple viruses, including influenza, COVID-19, RSV. Clinical trials with COVID-19 patients have confirmed potential, sparking further investigation into mechanisms action. study explores probenecid’s significant anti-inflammatory properties, focusing on ability to inhibit inflammasome activation. Our aims unravel effects NLRP3 MAPK signaling pathways using murine macrophages relevant inflammation model. We reveal that treatment blocks JNK ERK without p38 MAPK, suppressing Additionally, does not affect NFκB-directed protein expression, although it efficiently inhibits outputs, e.g., IL-1β pyroptosis. These results indicate potential therapeutic applications.
Язык: Английский
Процитировано
1
Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)
Опубликована: Июнь 15, 2024
Abstract PANoptosis represents a novel type of programmed cell death (PCD) with distinctive features that incorporate elements pyroptosis, apoptosis, and necroptosis. is governed by newly discovered cytoplasmic multimeric protein complex known as the PANoptosome. Unlike each these PCD types individually, still in early stages research warrants further exploration its specific regulatory mechanisms primary targets. In this review, we provide brief overview conceptual framework molecular components PANoptosis. addition, highlight recent advances understanding therapeutic applications By elucidating crosstalk between apoptosis necroptosis summarizing functional consequences special focus on tumor immune microenvironment, review aims to theoretical basis for potential application cancer therapy.
Язык: Английский
Процитировано
6
International Immunopharmacology, Год журнала: 2024, Номер 139, С. 112710 - 112710
Опубликована: Июль 18, 2024
Язык: Английский
Процитировано
6
Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown
Опубликована: Сен. 2, 2024
Язык: Английский
Процитировано
6
Science Advances, Год журнала: 2024, Номер 10(45)
Опубликована: Ноя. 8, 2024
PANoptosis has recently emerged as a potential approach to improve the immune microenvironment. However, current methods for inducing are limited. Herein, through biological screening, rational use of nutrient metal ions Cu
Язык: Английский
Процитировано
5
Heliyon, Год журнала: 2024, Номер 10(17), С. e37192 - e37192
Опубликована: Авг. 30, 2024
In immunology, the role of macrophages extends far beyond their traditional classification as mere phagocytes; they emerge pivotal architects immune response, with function being significantly influenced by multidimensional environmental stimuli. This review investigates nuanced mechanisms which diverse external signals ranging from chemical cues to physical stress orchestrate macrophage polarization, a process that is crucial for modulation responses. By transitioning between pro-inflammatory (M1) and anti-inflammatory (M2) states, exhibit remarkable plasticity, enabling them adapt influence surroundings effectively. The exploration polarization provides compelling narrative on how these cells can be manipulated foster an environment conducive tissue repair regeneration. Highlighting cutting-edge research, this presents innovative strategies leverage dynamic interplay environment, proposing novel therapeutic avenues harness potential in regenerative medicine. Moreover, critically evaluates current challenges future prospects translating macrophage-centered laboratory clinical applications.
Язык: Английский
Процитировано
4