The evolution of the concept of stress and the framework of the stress system

Cell Stress, Journal Year: 2021, Volume and Issue: 5(6), P. 76 - 85

Published: May 31, 2021

Stress is a central concept in biology and has now been widely used psychological, physiological, social, even environmental fields. However, the of stress was cross-utilized to refer different elements system including stressful stimulus, stressor, response, effect. Here, we summarized evolution framework system. We find although developed from Selye's "general adaptation syndrome", it expanded evolved significantly. defined as state homeostasis being challenged, both local stress. A specific stressor may potentially bring about stress, while intensity beyond threshold commonly activate hypothalamic-pituitary-adrenal axis result systematic response. The indicates that includes three types: sustress (inadequate stress), eustress (good distress (bad stress). Both might impair normal physiological functions lead pathological conditions, benefit health through hormesis-induced optimization homeostasis. Therefore, an optimal level essential for building biological shields guarantee life processes.

Language: Английский

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Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways

eNeuro, Journal Year: 2021, Volume and Issue: 8(6), P. ENEURO.0315 - 21.2021

Published: Nov. 1, 2021

Abstract The lateral septum (LS) is implicated as a hub that regulates variety of affects, such reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated structure homogeneity, exhibits multifaceted functions. Emerging evidence suggests different functions LS are mediated largely by its diverse input output connections. It has also become clear heterogeneous region, where dorsal ventral poles play dissociable often opposing roles. This functional heterogeneity can be explained distinct hippocampal inputs along dorsoventral axis, well antagonizing connections between subregions. Similarly, outputs from subregions to respective downstream targets, hypothalamic, preoptic, tegmental areas, account for this heterogeneity. In review, we provide an updated perspective on subregion classification, connectivity, We identify key questions have yet addressed in field.

Language: Английский

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NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 31, 2022

Abstract Emotional stress is considered a severe pathogenetic factor of psychiatric disorders. However, the circuit mechanisms remain largely unclear. Using three-chamber vicarious social defeat (3C-VSDS) model in mice, we here show that chronic emotional (CES) induces anxiety-like behavior and transient interaction changes. Dopaminergic neurons ventral tegmental area (VTA) are required to control this behavioral deficit. VTA dopaminergic neuron hyperactivity induced by CES involved innate anxiogenic environment. Chemogenetic activation directly triggers behavior, while chemogenetic inhibition these promotes resilience CES-induced behavior. Moreover, receiving nucleus accumbens (NAc) projections activated mice. Bidirectional modulation NAc-VTA mimics or reverses In conclusion, propose critically establishes regulates This study not only characterizes preclinical representative nuanced aspect CES, but also provides insight circuit-level neuronal processes underlie empathy-like

Language: Английский

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Endocannabinoids, cannabinoids and the regulation of anxiety

Neuropharmacology, Journal Year: 2021, Volume and Issue: 195, P. 108626 - 108626

Published: June 8, 2021

Language: Английский

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Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 12, 2022

Abstract Ketamine treatment decreases depressive symptoms within hours, but the mechanisms mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity of adult-born immature granule neurons (ABINs) in mouse hippocampal dentate gyrus is both necessary and sufficient for ketamine. activates ABINs parallel with its behavioral stressed unstressed mice. Chemogenetic inhibition ABIN blocks ketamine, indicating this effects. Conversely, chemogenetic activation without any change neuron numbers mimics cellular increased These findings thus identify a specific cell population mediates actions can potentially be targeted to limit ketamine’s side while preserving therapeutic efficacy.

Language: Английский

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Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 28, 2023

Abstract The ventral striatum is a reward center implicated in the pathophysiology of depression. It contains islands Calleja, clusters dopamine D3 receptor-expressing granule cells, predominantly olfactory tubercle (OT). These OT neurons regulate self-grooming, repetitive behavior manifested affective disorders. Here we show that chronic restraint stress (CRS) induces robust depression-like behaviors mice and decreases excitability neurons. Ablation or inhibition these leads to behaviors, whereas their activation ameliorates CRS-induced behaviors. Moreover, has rewarding effect, which diminishes when grooming blocked. Finally, propose model explains how may influence release via synaptic connections with spiny projection (SPNs) project midbrain Our study reveals crucial role bidirectionally mediating suggesting potential therapeutic target.

Language: Английский

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Microglia-Derived Insulin-like Growth Factor 1 Is Critical for Neurodevelopment

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 184 - 184

Published: Jan. 18, 2024

Insulin-like growth factor 1 (IGF-1) is a peptide hormone essential for the proper development and of organism, as complete knockout

Language: Английский

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Procoagulant, antibacterial and antioxidant high-strength porous hydrogel adhesives in situ formed via self-gelling hemostatic microsheets for emergency hemostasis and wound repair

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122936 - 122936

Published: Oct. 31, 2024

Language: Английский

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Ventral striatal islands of Calleja neurons control grooming in mice

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(12), P. 1699 - 1710

Published: Nov. 18, 2021

Language: Английский

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Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward

Neuron, Journal Year: 2022, Volume and Issue: 110(20), P. 3356 - 3373.e8

Published: Sept. 6, 2022

The use of body-focused repetitive behaviors (BFRBs) is conceptualized as a means coping with stress. However, the neurological mechanism by which affect anxiety regulation unclear. Here, we identify that excitatory somatostatin-positive neurons in medial paralemniscal nucleus (MPLSST neurons) mice promote self-grooming and encode reward. MPLSST display prominent grooming-related neuronal activity. Loss function impairs both post-stress alleviation. Activation rewarding sufficient to drive reinforcement activating dopamine (DA) ventral tegmental area (VTA) eliciting release. neuropeptide SST facilitates impact neurons. neuron-mediated triggered input from central amygdala (CeA). Our study reveals dual role CeA-MPLSST-VTADA circuit conceptualizes an interface linking stress reward systems mice.

Language: Английский

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