Life,
Год журнала:
2023,
Номер
13(10), С. 2023 - 2023
Опубликована: Окт. 8, 2023
The
human
gut
microbiota
(GM)
is
a
complex
microbial
ecosystem
that
colonises
the
gastrointestinal
tract
(GIT)
and
comprised
of
bacteria,
viruses,
fungi,
protozoa.
GM
has
symbiotic
relationship
with
its
host
fundamental
for
body
homeostasis.
not
limited
to
scope
GIT,
but
there
are
bidirectional
interactions
between
other
organs,
highlighting
concept
"gut-organ
axis".
Any
deviation
from
normal
composition
GM,
termed
"microbial
dysbiosis",
implicated
in
pathogenesis
various
diseases.
Only
few
studies
have
demonstrated
modifications
disease
phenotypes,
it
still
unknown
whether
an
altered
contributes
or
simply
reflects
status.
Restoration
probiotics
prebiotics
been
postulated,
evidence
effects
limited.
Prebiotics
substrates
"selectively
utilized
by
microorganisms,
conferring
health
benefit".
This
study
highlights
vital
organs
demonstrates
dysbiosis
emergence
certain
representative
Finally,
this
article
focuses
on
potential
as
target
therapy
manipulate
presents
gaps
literature
research.
PLoS ONE,
Год журнала:
2022,
Номер
17(1), С. e0262057 - e0262057
Опубликована: Янв. 13, 2022
Respiratory
tract
infections
(RTIs)
are
extremely
common
and
can
cause
gastrointestinal
symptoms
changes
to
the
gut
microbiota,
yet
these
effects
poorly
understood.
We
conducted
a
systematic
review
evaluate
reported
evidence
of
microbiome
alterations
in
patients
with
RTI
compared
healthy
controls
(PROSPERO:
CRD42019138853).
systematically
searched
Medline,
Embase,
Web
Science,
Cochrane
Clinical
Trial
Database
for
studies
published
between
January
2015
June
2021.
Studies
were
eligible
inclusion
if
they
human
cohorts
describing
an
infection
was
caused
by
viral
or
bacterial
pathogen.
Dual
data
screening
extraction
narrative
synthesis
performed.
identified
1,593
articles
assessed
11
full
texts
inclusion.
Included
(some
nested)
context
Severe
Acute
Syndrome
Coronavirus
2
(SARS-CoV-2)
(n
=
5),
influenza
(H1N1
H7N9)
2),
Tuberculosis
(TB)
4),
Community-Acquired
Pneumonia
CAP
2)
recurrent
RTIs
(rRTI)
1)
infections.
found
decrease
diversity
(Shannon)
1.45
units
(95%
CI,
0.15–2.50
[
p
,
<0.0001])
lower
abundance
taxa
(p,
0.0086).
Meta-analysis
Shannon
value
showed
considerable
heterogeneity
(I
94.42).
Unbiased
analysis
displayed
as
funnel
plot
revealed
depletion
Lachnospiraceae,
Ruminococcaceae
Ruminococcus
enrichment
Enterococcus
.
There
important
absence
lack
cohort
reporting
high
may
be
explained
variations
methods
confounder
effects.
Further
needed
understand
RTI-induced
better
interplay
microbes
respiratory
health.
Long-term
sequelae
of
coronavirus
disease
(COVID)-19
are
frequent
and
major
concern.
Severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection
affects
the
host
gut
microbiota,
which
is
linked
to
severity
in
patients
with
COVID-19.
Here,
we
report
that
microbiota
post-COVID
subjects
had
a
remarkable
predominance
Enterobacteriaceae
strains
an
antibiotic-resistant
phenotype
compared
healthy
controls.
Additionally,
short-chain
fatty
acid
(SCFA)
levels
were
reduced
feces.
Fecal
transplantation
from
germ-free
mice
led
lung
inflammation
worse
outcomes
during
pulmonary
by
multidrug-resistant
Klebsiella
pneumoniae.
transplanted
also
exhibited
poor
cognitive
performance.
Overall,
show
prolonged
impacts
SARS-CoV-2
on
persist
after
have
cleared
virus.
Together,
these
data
demonstrate
can
directly
contribute
sequelae,
suggesting
it
may
be
potential
therapeutic
target.
Life,
Год журнала:
2023,
Номер
13(10), С. 2023 - 2023
Опубликована: Окт. 8, 2023
The
human
gut
microbiota
(GM)
is
a
complex
microbial
ecosystem
that
colonises
the
gastrointestinal
tract
(GIT)
and
comprised
of
bacteria,
viruses,
fungi,
protozoa.
GM
has
symbiotic
relationship
with
its
host
fundamental
for
body
homeostasis.
not
limited
to
scope
GIT,
but
there
are
bidirectional
interactions
between
other
organs,
highlighting
concept
"gut-organ
axis".
Any
deviation
from
normal
composition
GM,
termed
"microbial
dysbiosis",
implicated
in
pathogenesis
various
diseases.
Only
few
studies
have
demonstrated
modifications
disease
phenotypes,
it
still
unknown
whether
an
altered
contributes
or
simply
reflects
status.
Restoration
probiotics
prebiotics
been
postulated,
evidence
effects
limited.
Prebiotics
substrates
"selectively
utilized
by
microorganisms,
conferring
health
benefit".
This
study
highlights
vital
organs
demonstrates
dysbiosis
emergence
certain
representative
Finally,
this
article
focuses
on
potential
as
target
therapy
manipulate
presents
gaps
literature
research.
