Interference of ATP‐Adenosine Axis by Engineered Biohybrid for Amplifying Immunogenic Cell Death‐Mediated Antitumor Immunotherapy DOI

Xin‐Chen Deng,

Jun‐Long Liang,

Shi‐Man Zhang

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 18, 2024

Abstract Immunogenic cell death (ICD) often results in the production and accumulation of adenosine (ADO), a byproduct that negatively impacts therapeutic effect as well facilitates tumor development metastasis. Here, an innovative strategy is elaborately developed to effectively activate ICD while avoiding generation immunosuppressive adenosine. Specifically, ZIF‐90, ATP‐responsive consumer, synthesized core carrier encapsulate AB680 (CD73 inhibitor) then coated with iron‐polyphenol layer prepare inducer (AZTF), which further grafted onto prebiotic bacteria via esterification reaction obtain engineered biohybrid (Bc@AZTF). Particularly, designed Bc@AZTF can actively enrich sites respond acidic microenvironment offload AZTF nanoparticles, consume intracellular ATP (iATP) content simultaneously inhibit ATP‐adenosine axis reduce adenosine, thereby alleviating adenosine‐mediated immunosuppression strikingly amplifying effect. Importantly, synergy anti‐PD‐1 (αPD‐1) not only establishes collaborative antitumor immune network potentiate effective tumoricidal immunity but also activates long‐lasting memory effects manage recurrence rechallenge, presenting new paradigm for treatment combined metabolism.

Язык: Английский

Redox-responsive polymer micelles co-encapsulating immune checkpoint inhibitors and chemotherapeutic agents for glioblastoma therapy DOI Creative Commons
Zhiqi Zhang, Xiaoxuan Xu, Jiawei Du

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 6, 2024

Abstract Immunotherapy with immune checkpoint blockade (ICB) for glioblastoma (GBM) is promising but its clinical efficacy seriously challenged by the blood-tumor barrier (BTB) and immunosuppressive tumor microenvironment. Here, anti-programmed death-ligand 1 antibodies (aPD-L1) are loaded into a redox-responsive micelle ICB further amplified paclitaxel (PTX)-induced immunogenic cell death (ICD) via co-encapsulation approach reinvigoration of local anti-GBM responses. Consequently, micelles cross BTB retained in reductive microenvironment without altering bioactivity aPD-L1. The enhanced aPD-L1 PTX combination suppression primary recurrent GBM, accumulation cytotoxic T lymphocytes, induction long-lasting immunological memory orthotopic GBM-bearing mice. facilitating efficient antibody delivery combining chemotherapeutic agent-induced ICD demonstrate that chemo-immunotherapy might reprogram immunity to empower immunotherapy against GBM.

Язык: Английский

Процитировано

33
Nanomedomics DOI

Ganghao Liang,

Wanqing Cao, Dongsheng Tang

и другие.

ACS Nano, Год журнала: 2024, Номер 18(17), С. 10979 - 11024

Опубликована: Апрель 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Язык: Английский

Процитировано

30
Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation DOI

Baoyi Li,

Menghang Zu,

Aodi Jiang

и другие.

Biomaterials, Год журнала: 2024, Номер 307, С. 122530 - 122530

Опубликована: Март 11, 2024

Язык: Английский

Процитировано

21
Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death DOI

Lvqin Fu,

Xianbin Ma,

Yuan‐Tong Liu

и другие.

Chinese Chemical Letters, Год журнала: 2021, Номер 33(4), С. 1718 - 1728

Опубликована: Окт. 29, 2021

Язык: Английский

Процитировано

60
In situ targeting nanoparticles-hydrogel hybrid system for combined chemo-immunotherapy of glioma DOI
Xiaoqi Wang, Lu Ye,

Weichong He

и другие.

Journal of Controlled Release, Год журнала: 2022, Номер 345, С. 786 - 797

Опубликована: Март 31, 2022

Язык: Английский

Процитировано

53
Salmonella-mediated blood‒brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy DOI Creative Commons
Ze Mi, Qing Yao, Yan Qi

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 13(2), С. 819 - 833

Опубликована: Сен. 25, 2022

Chemotherapy is an important adjuvant treatment of glioma, while the efficacy far from satisfactory, due not only to biological barriers blood‒brain barrier (BBB) and blood‒tumor (BTB) but also intrinsic resistance glioma cells via multiple survival mechanisms such as up-regulation P-glycoprotein (P-gp). To address these limitations, we report a bacteria-based drug delivery strategy for BBB/BTB transportation, targeting, chemo-sensitization. Bacteria selectively colonized into hypoxic tumor region modulated microenvironment, including macrophages repolarization neutrophils infiltration. Specifically, migration was employed hitchhiking doxorubicin (DOX)-loaded bacterial outer membrane vesicles (OMVs/DOX). By virtue surface pathogen-associated molecular patterns derived native bacteria, OMVs/DOX could be recognized by neutrophils, thus facilitating targeted with significantly enhanced accumulation 18-fold compared classical passive targeting effect. Moreover, P-gp expression on silenced bacteria type III secretion effector sensitize DOX, resulting in complete eradication 100% all treated mice. In addition, were finally cleared anti-bacterial activity DOX minimize potential infection risk, cardiotoxicity avoided, achieving excellent compatibility. This work provides efficient trans-BBB/BTB cell therapy.

Язык: Английский

Процитировано

51
Escherichia coli Mimetic Gold Nanorod-Mediated Photo- and Immunotherapy for Treating Cancer and Its Metastasis DOI
Juyoung Hwang,

Eun‐Koung An,

Sojung Kim

и другие.

ACS Nano, Год журнала: 2022, Номер 16(5), С. 8472 - 8483

Опубликована: Апрель 25, 2022

Most cancer-related deaths are due to metastasis or recurrence. Therefore, the ultimate goal of cancer therapy will be treat metastatic and recurrent cancers. Combination for one trial effective treating In this study, Escherichia coli-mimetic nanomaterials synthesized using coli membrane proteins, adhesion gold nanorods, which named E. mimetic AuNRs (ECA), combination against its ECA treatment with 808 nm laser irradiation eliminates CT-26 4T1 tumors via a photothermal effect. induces activation immune cells in tumor-draining lymph nodes. The mice cured from tumor by rechallenged those lung form, results showed that first challenge prevents infiltration second challenge. This preventive effect growth is aided antigen-specific T cell immunity. Overall, these findings show nanomaterial dual functions as primary cancers immunotherapy preventing recurrence metastasis.

Язык: Английский

Процитировано

42
Enhanced Immunogenic Cell Death and Antigen Presentation via Engineered Bifidobacterium bifidum to Boost Chemo-immunotherapy DOI

Tingting He,

Lu Wang,

Shuangquan Gou

и другие.

ACS Nano, Год журнала: 2023, Номер 17(11), С. 9953 - 9971

Опубликована: Май 22, 2023

The immunogenic cell death (ICD) of tumor cells has aroused great interest in the field immunotherapy, mainly due to production plentiful tumor-associated antigens (TAAs) and damage-associated molecule patterns. However, doxorubicin (DOX)-induced tumor-specific T-cell-mediated immune response is usually very weak because antigen presentation deficiency immunosuppressive microenvironment (ITME). Herein, probiotic Bifidobacterium bifidum (Bi) was covalently modified with DOX-loaded CaP/SiO2 nanoparticles (DNPs@Bi) for therapy. On one hand, pH-responsive release DOX could induce chemotherapy ICD ITME. other tumor-targeting Bi able significantly enhance TAAs from B16F10 DCs via Cx43-dependent gap junctions. Due combination enhanced presentation, maturation infiltration cytotoxic T lymphocytes ITME were stimulated. As a result, vivo antitumor experiments demonstrated that DNPs@Bi prolonged survival rate inhibited progression metastasis. This strategy bacterial-driven hypoxia-targeting delivery systems offers promising approach chemo-immunotherapy.

Язык: Английский

Процитировано

39
In situ cellular hitchhiking of nanoparticles for drug delivery DOI Creative Commons
Edidiong Udofa, Zongmin Zhao

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 204, С. 115143 - 115143

Опубликована: Ноя. 24, 2023

Язык: Английский

Процитировано

28
Matrix Metalloproteinase-2-Induced Morphologic Transformation of Self-Assembled Peptide Nanocarriers Inhibits Tumor Growth and Metastasis DOI

Juanjuan Cao,

Xiaomeng Yuan,

Xinyu Sun

и другие.

ACS Materials Letters, Год журнала: 2023, Номер 5(3), С. 900 - 908

Опубликована: Фев. 23, 2023

Despite the rapid development of novel drug delivery systems, limited intratumor accumulation drugs and immunomodulatory function nanovehicles still limit their therapeutic efficiency. Deeper penetration can be achieved by reducing size nanocarriers after reaching tumor site. However, persistence such is due to small particle ease removal from tumors. Here, we design a matrix metalloproteinase-2 (MMP-2)-responsive peptide, AGLR, that encapsulate chemotherapeutic doxorubicin (DOX) self-assemble form spherical nanoparticles (NPs) in physiological environment, which enhances tissue. Upon cleavage MMP-2 overexpressed microenvironment, DOX/AGLR transformed NPs nanofibers (NFs), improving DOX retention time tumors vivo. Furthermore, penetrates extracellular (ECM) inhibited upregulation CCL2 CD31, inhibiting growth lung metastasis. Importantly, increased proportion DC cells decreased proliferation Treg cells. The expression TGF-β PD-L1 was downregulated, indicating alleviated immunosuppressive microenvironment. This enzyme-responsive, morphologically transformable drug-delivery strategy provides promising general therapy modality with enhanced antitumor efficacy immunomodulation.

Язык: Английский

Процитировано

26