Camptothecin
(CPT)
is
a
highly
cytotoxic
molecule
with
excellent
antitumor
activity
against
various
cancers.
However,
its
clinical
application
severely
limited
by
poor
water
solubility,
easy
inactivation,
and
severe
toxicity.
Structural
modifications
nanoformulations
represent
two
crucial
avenues
for
camptothecin's
development.
the
potential
further
structural
limited,
camptothecin
nanoparticles
fabricated
via
physical
loading
have
drawbacks
of
low
drug
leakage.
Prodrug-based
CPT
shown
unique
advantages,
including
increased
loading,
reduced
burst
release,
improved
bioavailability,
minimal
toxic
side
effects.
Stimulus-responsive
nano-prodrugs
that
respond
to
endogenous
or
exogenous
stimuli
introducing
activatable
linkers
achieve
spatiotemporally
responsive
release
at
tumor
site.
This
review
comprehensively
summarizes
latest
research
advances
in
stimulus-responsive
nano-prodrugs,
preparation
strategies,
mechanisms,
their
applications
cancer
therapy.
Special
focus
placed
on
mechanisms
characteristics
treatment.
Furthermore,
prodrugs
are
discussed.
Finally,
challenges
future
directions
be
valuable
readers
engaged
prodrug
expected.
Drug Delivery,
Год журнала:
2022,
Номер
29(1), С. 2130 - 2161
Опубликована: Июль 10, 2022
Chemotherapy
drugs
have
been
used
for
a
long
time
in
the
treatment
of
cancer,
but
serious
side
effects
are
caused
by
inability
drug
to
be
solely
delivered
tumor
when
treating
cancer
with
chemotherapy.
Natural
products
attracted
more
and
attention
due
antitumor
effect
multiple
ways,
abundant
resources
less
effects.
Therefore,
combination
natural
active
ingredients
chemotherapy
may
an
effective
strategy,
which
can
inhibit
growth
multidrug
resistance,
reduce
drugs.
Nano-drug
co-delivery
system
(NDCDS)
play
important
role
This
review
provides
comprehensive
summary
research
status
application
prospect
nano-delivery
strategies
drugs,
aiming
provide
basis
development
anti-tumor
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 8, 2025
Cancer
is
a
major
killer
threatening
modern
human
health
and
leading
cause
of
death
worldwide.
Due
to
the
heterogeneity
complexity
cancer,
traditional
treatments
have
limited
effectiveness.
To
address
this
problem,
an
increasing
number
researchers
medical
professionals
are
working
develop
new
ways
treat
cancer.
Bacteria
chemotaxis
that
can
target
colonize
tumor
tissue,
as
well
activate
anti-tumor
immune
responses,
which
makes
them
ideal
for
biomedical
applications.
With
rapid
development
nanomedicine
synthetic
biology
technologies,
bacteria
extensively
used
carriers
drug
delivery
tumors,
holds
promise
overcoming
limitations
conventional
cancer
treatment
regimens.
This
paper
summarizes
examples
anti-cancer
drugs
delivered
by
bacterial
carriers,
their
strengths
weaknesses.
Further,
we
emphasize
carrier
systems
in
clinical
translation.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
64(2), С. 381 - 406
Опубликована: Авг. 8, 2022
Bioactive
compounds
represent
a
broad
class
of
dietary
metabolites
derived
from
fruits
and
vegetables,
such
as
polyphenols,
carotenoids
glucosinolates
with
potential
for
cancer
prevention.
Curcumin,
resveratrol,
quercetin,
β-carotene
have
been
the
most
widely
applied
bioactive
in
chemoprevention.
Lately,
many
approaches
to
encapsulating
components
nano-delivery
systems
improved
biomolecules'
stability
targeted
delivery.
In
this
review,
we
critically
analyze
compounds,
including
polymeric
nanoparticles
(NPs),
solid
lipid
(SLN),
nanostructured
carriers
(NLC),
liposomes,
niosomes,
nanoemulsions
(NEs)
use
therapy.
Efficacy
studies
nanoformulations
using
cell
lines
vivo
models
updated
human
clinical
trials
are
also
discussed.
Nano-delivery
were
found
improve
therapeutic
efficacy
molecules
against
various
types
(e.g.,
breast,
prostate,
colorectal
lung
cancer)
mainly
due
antiproliferation
pro-apoptotic
effects
tumor
cells.
Furthermore,
some
promised
combination
therapy
standard
chemotherapeutic
agents,
increased
efficiency
fewer
side
effects.
These
opportunities
identified
developed
ensure
more
excellent
safety
novel
herbal
medicines
enabling
insights
designing
Abstract
The
immune
system
takes
part
in
most
physiological
and
pathological
processes
of
the
body,
including
occurrence
development
cancer.
Immunotherapy
provides
a
promising
modality
for
inhibition
even
cure
During
immunotherapy,
immunogenic
cell
death
(ICD)
tumor
cells
induced
by
chemotherapy,
radiotherapy,
phototherapy,
bioactive
materials,
so
forth,
triggers
series
cellular
responses
causing
release
tumor‐associated
antigens
damage‐associated
molecular
patterns,
which
ultimately
activate
innate
adaptive
responses.
Among
them,
ICD‐induced
biomaterials
attract
increasing
conditions
as
benefit
biosafety
multifunctional
modifications.
This
Review
summarizes
research
progress
inducing
ICD
via
triggering
endoplasmic
reticulum
oxidative
stress,
mitochondrial
dysfunction,
membrane
rupture
discusses
application
prospects
ICD‐inducing
clinical
practice
cancer
immunotherapy.
ACS Nano,
Год журнала:
2023,
Номер
17(11), С. 10925 - 10937
Опубликована: Май 23, 2023
Immunotherapy
as
an
alternative
treatment
strategy
for
B-cell
lymphoma
is
undesirable
because
of
tumor
heterogeneity
and
immune
surveillance.
Spermidine
(SPM),
a
regulator
the
microenvironment
(TME),
can
facilitate
release
damage-associated
molecular
patterns
(DAMPs)
from
cancer
cells,
promote
recognition,
thus
alleviate
surveillance
in
TME.
Hence,
this
work,
self-assembled
spermidine-based
metal-immunopeptide
nanocomplexes
(APP-Fe
NCs;
APP
anti-programmed
death
ligand-1
peptide)
with
pH-responsive
kinetics
were
prepared
via
flash
nanocomplexation
(FNC)
technique
based
on
noncovalent
interaction
between
APP-SPM-dextran
(DEX)
sodium
tripolyphosphate
(TPP)
coordination
Fe3+
TPP.
An
vitro
study
suggested
that
APP-Fe
NCs
effectively
induce
strong
oxidative
stress
mitochondrial
dysfunction
subsequently
lead
to
ferroptosis
cells
by
interfering
homeostasis
cells.
Further
investigation
mice
models
demonstrated
inhibited
growth
liver
metastasis
lymphomas.
Mechanistically,
triggering
tissues,
these
spermidine-containing
efficiently
facilitated
DAMPs
ultimately
reshaped
TME
enhance
immunotherapy
efficacy
lymphoma.
Combined
its
good
histocompatibility
facile
preparation
technique,
regulation
may
hold
potential
cascade
amplification
combinative
clinic.
