Toxics,
Год журнала:
2023,
Номер
11(2), С. 185 - 185
Опубликована: Фев. 16, 2023
Antimicrobial
contamination
and
antimicrobial
resistance
have
become
global
environmental
health
problems.
A
large
number
of
antimicrobials
are
used
in
medical
animal
husbandry,
leading
to
the
continuous
release
residual
into
environment.
It
not
only
causes
ecological
harm,
but
also
promotes
occurrence
spread
resistance.
The
role
factors
is
often
overlooked.
There
a
antimicrobial-resistant
bacteria
genes
human
beings,
which
increases
likelihood
that
pathogenic
acquire
resistance,
adds
opportunities
for
contact
with
pathogens.
In
this
paper,
we
review
fate
environment,
including
occurrence,
spread,
impact
on
health.
More
importantly,
emphasizes
can
exacerbate
future,
timely
removal
environment
will
be
more
effective
alleviating
Nucleic Acids Research,
Год журнала:
2022,
Номер
51(D1), С. D690 - D699
Опубликована: Окт. 20, 2022
Abstract
The
Comprehensive
Antibiotic
Resistance
Database
(CARD;
card.mcmaster.ca)
combines
the
Ontology
(ARO)
with
curated
AMR
gene
(ARG)
sequences
and
resistance-conferring
mutations
to
provide
an
informatics
framework
for
annotation
interpretation
of
resistomes.
As
version
3.2.4,
CARD
encompasses
6627
ontology
terms,
5010
reference
sequences,
1933
mutations,
3004
publications,
5057
detection
models
that
can
be
used
by
accompanying
Gene
Identifier
(RGI)
software
annotate
genomic
or
metagenomic
sequences.
Focused
curation
enhancements
since
2020
include
expanded
β-lactamase
curation,
incorporation
likelihood-based
Mycobacterium
tuberculosis,
addition
disinfectants
antiseptics
plus
their
associated
ARGs,
systematic
resistance-modifying
agents.
This
includes
180
new
families,
15
drug
classes,
1
resistance
mechanism,
two
ontological
relationships:
evolutionary_variant_of
is_small_molecule_inhibitor.
In
silico
prediction
resistomes
prevalence
statistics
ARGs
has
been
377
pathogens,
21,079
chromosomes,
2,662
islands,
41,828
plasmids
155,606
whole-genome
shotgun
assemblies,
resulting
in
collation
322,710
unique
ARG
allele
New
features
CARD:Live
collection
community
submitted
isolate
resistome
data
introduction
standardized
character
Short
Names
support
machine
learning
efforts.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Дек. 1, 2022
Abstract
Antimicrobial
resistance
(AMR)
is
a
major
threat
to
global
health.
Understanding
the
emergence,
evolution,
and
transmission
of
individual
antibiotic
genes
(ARGs)
essential
develop
sustainable
strategies
combatting
this
threat.
Here,
we
use
metagenomic
sequencing
analyse
ARGs
in
757
sewage
samples
from
243
cities
101
countries,
collected
2016
2019.
We
find
regional
patterns
resistomes,
these
differ
between
subsets
corresponding
drug
classes
are
partly
driven
by
taxonomic
variation.
The
genetic
environments
49
common
highly
diverse,
with
most
carried
multiple
distinct
genomic
contexts
globally
sometimes
on
plasmids.
Analysis
flanking
sequence
revealed
ARG-specific
dispersal
limitation
transmission.
Our
data
furthermore
suggest
certain
geographies
more
prone
events
should
receive
additional
attention.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Март 27, 2023
Abstract
Soil
contamination
is
one
of
the
main
threats
to
ecosystem
health
and
sustainability.
Yet
little
known
about
extent
which
soil
contaminants
differ
between
urban
greenspaces
natural
ecosystems.
Here
we
show
that
adjacent
areas
(i.e.,
natural/semi-natural
ecosystems)
shared
similar
levels
multiple
(metal(loid)s,
pesticides,
microplastics,
antibiotic
resistance
genes)
across
globe.
We
reveal
human
influence
explained
many
forms
worldwide.
Socio-economic
factors
were
integral
explaining
occurrence
further
increased
linked
with
changes
in
microbial
traits
including
genes
associated
environmental
stress
resistance,
nutrient
cycling,
pathogenesis.
Taken
together,
our
work
demonstrates
human-driven
nearby
mirrors
globally,
highlights
have
potential
cause
dire
consequences
for
sustainability
wellbeing.
Trends in biotechnology,
Год журнала:
2023,
Номер
41(3), С. 331 - 341
Опубликована: Янв. 28, 2023
Of
late,
global
food
security
has
been
under
threat
by
the
coronavirus
disease
2019
(COVID-19)
pandemic
and
recent
military
conflict
in
Eastern
Europe.
This
article
presents
objectives
of
Sustainable
Development
Goals
European
Green
Deal
related
to
achieving
sustainable
development
Union
(EU)
agriculture,
taking
aforementioned
threats
into
account.
In
addition,
it
discusses
future
plant
agricultural
biotechnology
artificial
intelligence
(AI)
systems,
considering
their
potential
for
reaching
goal
security.
Paradoxically,
present
challenging
situation
may
allow
politicians
stakeholders
EU
realize
opportunities
use
sector.
