The cell biology of archaea

Nature Microbiology, Год журнала: 2022, Номер 7(11), С. 1744 - 1755

Опубликована: Окт. 17, 2022

Язык: Английский

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A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 23, 2024

Язык: Английский

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Review: Reducing enteric methane emissions improves energy metabolism in livestock: is the tenet right?

animal, Год журнала: 2023, Номер 17, С. 100830 - 100830

Опубликована: Апрель 28, 2023

The production of enteric methane in the gastrointestinal tract livestock is considered as an energy loss equations for estimating metabolism feeding systems. Therefore, spared resulting from specific inhibition emissions should be re-equilibrated with other factors equation. And, it commonly assumed that net feeds increases, thus benefitting functions, particularly ruminants due to important rumen. Notwithstanding, we confirm this work does not transpose into consistent improvements production. Theoretical calculations flows using experimental data show expected improvement small and difficult detect under prevailing, moderate (≈25%) obtained feed additives inhibiting methanogenesis. Importantly, calculation partitioning canonical models might adequate when methanogenesis inhibited. There a lack information on various parameters play role may affected provoked abatement methane. formula used calculate heat based respiratory exchanges validated Also, better understanding needed effects fermentation products, heat, microbial biomass. Inhibition induces accumulation H2, main substrate produce methane, has no energetic value host, extensively by majority rumen microbes. Currently, fate excess H2 its consequences microbiota host are well known. All additional will provide account transactions Based available information, concluded claim translate more feed-efficient animals warranted.

Язык: Английский

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A compendium of viruses from methanogenic archaea reveals their diversity and adaptations to the gut environment

Nature Microbiology, Год журнала: 2023, Номер 8(11), С. 2170 - 2182

Опубликована: Сен. 25, 2023

Язык: Английский

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Limosilactobacillus Regulating Microbial Communities to Overcome the Hydrolysis Bottleneck with Efficient One‐Step Co‐Production of H₂ and CH₄

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Abstract The efficient co‐production of H 2 and CH 4 via anaerobic digestion (AD) requires separate stages, as it cannot yet be achieved in one step. Lactic acid bacteria (LAB) ( Limosilactobacillus ) release acetate by enhancing hydrolysis, potentially increasing production with simultaneous accumulation. This study investigated the enhanced effect one‐step AD LAB elucidated its enhancement mechanisms. results showed that 236.3 times increase 7.1 are achieved, resulting profits 469.39 USD. Model substrates lignocellulosic straw, sodium acetate, confirmes work on hydrolysis stage subsequent sustainable volatile fatty during first 6 days AD. In this stage, enrichment carrying bglB xynB , glycolysis pathway, high activity protease, kinase, [FeFe] hydrogenase, jointly rapid accumulation, driving hydrogenotrophic methanogenesis dominated. From day 7 to 24, enriched Methanosarcina increased methenyltetrahydromethanopterin hydrogenase activity, continuously produced led mainly acetoclastic shift from methanogenesis. power generation capacity LAB‐enhanced is 333.33 China's 24,000 m 3 biogas plant.

Язык: Английский

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The evolving role of methanogenic archaea in mammalian microbiomes

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Сен. 1, 2023

Methanogenic archaea (methanogens) represent a diverse group of microorganisms that inhabit various environmental and host-associated microbiomes. These organisms play an essential role in global carbon cycling given their ability to produce methane, potent greenhouse gas, as by-product energy production. Recent advances culture-independent -dependent studies have highlighted increased prevalence methanogens the microbiome animal species. Moreover, there is increasing evidence methanogens, and/or methane they produce, may substantial human health disease. This review addresses expanding host-range emerging view host-specific adaptations methanogen biology ecology, implications for host

Язык: Английский

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The multi-kingdom microbiome of the goat gastrointestinal tract

Microbiome, Год журнала: 2023, Номер 11(1)

Опубликована: Окт. 2, 2023

Goat is an important livestock worldwide, which plays indispensable role in human life by providing meat, milk, fiber, and pelts. Despite recent significant advances microbiome studies, a comprehensive survey on the goat microbiomes covering gastrointestinal tract (GIT) sites, developmental stages, feeding styles, geographical factors still unavailable. Here, we surveyed its multi-kingdom microbial communities using 497 samples from ten sites along GIT.We reconstructed catalog (GMMC) including 4004 bacterial, 71 archaeal, 7204 viral genomes annotated over 4,817,256 non-redundant protein-coding genes. We revealed patterns of feeding-driven community dynamics GIT were likely associated with food digestion absorption capabilities disease risks, identified abundance large intestine-enriched genera involved plant fiber digestion. quantified effects various affecting distribution methane-producing microbes site, age, style, geography, 68 virulent viruses targeting methane producers via virus-bacterium/archaea interaction network.Together, our GMMC provides functional insights microbiota through microbiome-host interactions paves way to interventions for better eco-environmental qualities. Video Abstract.

Язык: Английский

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Mood Disorders: The Gut Bacteriome and Beyond

Biological Psychiatry, Год журнала: 2023, Номер 95(4), С. 319 - 328

Опубликована: Сен. 3, 2023

Knowledge of the microbiome-gut-brain axis has revolutionized field psychiatry. It is now well recognized that gut bacteriome associated with, and likely influences, pathogenesis mental disorders, including major depressive disorder bipolar disorder. However, whilst substantial advances in microbiome science have been made, we only scratched surface our understanding how these ecosystems might contribute to pathophysiology. Beyond bacteriome, research into lesser explored components microbiome, virome, mycobiome, archaeome, parasitome, increasingly suggesting relevance The contribution microbiomes beyond gut, oral, lung, small intestinal microbiomes, human health pathology should not be overlooked. Increasing both awareness less traversed fields critical improving therapeutic benefits treatments targeting fecal transplantation, postbiotics biogenics, dietary intervention. Interdisciplinary collaborations integrating systems biology approaches are required fully elucidate different microbial distinct niches interact with each other their hosts. Excitingly, may at start next revolution, thus one step closer informing precision psychiatry improve outcomes for those living illness.

Язык: Английский

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Good and bad dispositions between archaea and bacteria in the human gut: New insights from metagenomic survey and co-occurrence analysis

Synthetic and Systems Biotechnology, Год журнала: 2024, Номер 9(1), С. 88 - 98

Опубликована: Янв. 3, 2024

Archaea are an understudied component of the human microbiome. In this study, gut archaeome and bacteriome 60 healthy adults from different region were analyzed by whole-genome shotgun sequencing. ubiquitously found in a wide range abundances, reaching up to 7.2 %. The dominant archaeal phylum was Methanobacteriota, specifically family Methanobacteriaceae, encompassing more than 50 % samples. previously underestimated Thermoplasmatota, mostly composed Methanomassiliicoccaceae, dominated 10 subjects (>50 %) present all others except one. Halobacteriota, sole other phylum, occurred negligible concentration, for two samples (4.6-4.8 %). This finding confirmed that is primarily methanogenic organisms among known pathway: i) hydrogenotrophic reduction CO

Язык: Английский

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Anaerobic fungi in the tortoise alimentary tract illuminate early stages of host-fungal symbiosis and Neocallimastigomycota evolution

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 28, 2024

Abstract Anaerobic gut fungi (AGF, Neocallimastigomycota ) reside in the alimentary tract of herbivores. While their presence mammals is well documented, evidence for occurrence non-mammalian hosts currently sparse. Culture-independent surveys AGF tortoises identified a unique community, with three novel deep-branching genera representing >90% sequences most samples. Representatives all were successfully isolated under strict anaerobic conditions. Transcriptomics-enabled phylogenomic and molecular dating analyses indicated an ancient, position tree these genera, evolutionary divergence time estimate 104-112 million years ago (Mya). Such estimates push establishment animal- symbiosis from late to early Cretaceous. Further, tortoise-associated isolates (T-AGF) exhibited limited capacity plant polysaccharides metabolism lacked genes encoding several carbohydrate-active enzyme (CAZyme) families. Finally, we demonstrate that observed curtailed degradation capacities reduced CAZyme repertoire driven by paucity horizontal gene transfer (HGT) T-AGF genomes, compared mammalian counterparts. This was reflected altered cellulosomal production T-AGF. Our findings provide insights into phylogenetic diversity, ecological distribution, history, evolution fungal-host nutritional symbiosis, dynamics acquisition .

Язык: Английский

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