Journal of Ethnopharmacology, Год журнала: 2023, Номер 320, С. 117424 - 117424
Опубликована: Ноя. 19, 2023
Язык: Английский
Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442
Опубликована: Янв. 1, 2023
Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.
Язык: Английский
Процитировано
92
Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
80
Advanced Materials, Год журнала: 2023, Номер 36(1)
Опубликована: Авг. 1, 2023
Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.
Язык: Английский
Процитировано
71
Coordination Chemistry Reviews, Год журнала: 2024, Номер 505, С. 215677 - 215677
Опубликована: Янв. 31, 2024
Язык: Английский
Процитировано
46
Advanced Materials, Год журнала: 2024, Номер 36(19)
Опубликована: Фев. 7, 2024
Abstract Conjugated polymers (CPs) have promising applications in biomedical fields, such as disease monitoring, real‐time imaging diagnosis, and treatment. As a luminescent material with tunable emission, high brightness excellent stability, CPs are widely used fluorescent probes biological detection imaging. Rational molecular design structural optimization broadened absorption/emission range of CPs, which more conductive for diagnosis precision therapy. This review provides comprehensive overview recent advances the application aiming to elucidate their functional relationships. The fluorescence properties mechanism signal amplification first discussed, followed by an elucidation emerging detection. Subsequently, CPs‐based systems therapeutic strategies illustrated systematically. Finally, advancements utilizing electroactive materials bioelectronic devices also investigated. Moreover, challenges outlooks medicine discussed. Through this systematic review, it is hoped highlight frontier progress promote new breakthroughs fundamental research clinical transformation.
Язык: Английский
Процитировано
30
Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
20
Coordination Chemistry Reviews, Год журнала: 2025, Номер 528, С. 216379 - 216379
Опубликована: Янв. 4, 2025
Язык: Английский
Процитировано
4
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(37)
Опубликована: Май 23, 2023
Fluorescence imaging utilizing traditional organic fluorophores is extensively applied in both cellular and vivo studies. However, it faces significant obstacles, such as low signal-to-background ratio (SBR) spurious positive/negative signals, primarily due to the facile diffusion of these fluorophores. To cope with this challenge, orderly self-assembled functionalized have gained attention past decades. These can create nanoaggregates via a well-ordered self-assembly process, thus prolonging their residency time within cells settings. The development self-assembled-based an emerging field, such, review, we present summary progress challenges fluorophores, focusing on history, mechanisms, biomedical applications. We hope that insights provided herein will assist scientists further developing for situ imaging, sensing, therapy.
Язык: Английский
Процитировано
37
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(48)
Опубликована: Окт. 2, 2023
An accurate detection of lung metastasis is great significance for making better treatment choices and improving cancer prognosis, but remains a big challenge in clinical practice. In this study, we propose reinventing strategy to develop pH-activatable near-infrared (NIR) fluorescent nanoprobe, pulmonary tracer (denoted as PMT), based on assembly NIR dye IR780 calcium phosphate (CaP). By delicately tuning the intermolecular interactions during process doping content, well synthetic condition probe, fluorescence PMT could be finely adjusted via tumor acidity-triggered disassembly. Notably, selected PMT9 sharply convert subtle pH variations into distinct signal generate high ON/OFF contrast, dramatically reducing background signals. Benefiting from such preferable features, able precisely identify not only sites orthotopic models also metastases mice with remarkable signal-to-background ratio (SBR). This study provides unique turn shortcomings traditional vivo imaging advantages further expand application probe image associated lesions.
Язык: Английский
Процитировано
32
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)
Опубликована: Март 8, 2024
Although being applied as photosensitizers for photodynamic therapy, covalent organic frameworks (COFs) fail the precise fluorescence imaging in vivo and phototherapy deep-tissue, due to short excitation/emission wavelengths. Herein, this work proposes first example of NIR-II emissive benzobisthiadiazole-based COF-980. Comparing its ligands, structure COF-980 can more efficiently reducing energy gap (ΔE
Язык: Английский
Процитировано
18