NIR-II light in clinical oncology: opportunities and challenges

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(6), С. 449 - 467

Опубликована: Май 1, 2024

Язык: Английский

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An All‐Rounder for NIR‐II Phototheranostics: Well‐Tailored 1064 nm‐Excitable Molecule for Photothermal Combating of Orthotopic Breast Cancer

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(26)

Опубликована: Апрель 19, 2024

The second near-infrared (NIR-II, 1000-1700 nm) light-activated organic photothermal agent that synchronously enables satisfying NIR-II fluorescence imaging is highly warranted yet rather challenging on the basis of overwhelming nonradiative decay. Herein, such an agent, namely TPABT-TD, was tactfully designed and constructed via employing benzo[c]thiophene moiety as bulky electron donor/π-bridge tailoring peripheral molecular rotors. Benefitting from its high donor-acceptor strength finely modulated intramolecular motion, TPABT-TD simultaneously exhibits ultralong absorption in region, intense emission NIR-IIa (1300-1500 region nanoaggregates, conversion upon 1064 nm laser irradiation. Those intrinsic advantages endow nanoparticles with prominent fluorescence/photoacoustic/photothermal trimodal imaging-guided therapy against orthotopic 4T1 breast tumor negligible adverse effect.

Язык: Английский

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A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 29, 2024

Thermoelectric technology has recently emerged as a distinct therapeutic modality. However, its effectiveness is significantly limited by the restricted temperature gradient within living organisms. In this study, we introduce high-performance plasmonic-thermoelectric catalytic therapy utilizing urchin-like Cu

Язык: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122

Опубликована: Авг. 6, 2024

Язык: Английский

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Two Key Descriptors for Designing Second Near-Infrared Dyes and Experimental Validation

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(14), С. 9888 - 9896

Опубликована: Март 28, 2024

Second near-infrared (NIR-II) optical imaging technology has emerged as a powerful tool for diagnostic and image-guided surgery due to its higher contrast. However, general strategy efficiently designing NIR-II organic molecules is still lacking, because dyes are usually difficult synthesize, which impeded the rapid development of bioprobes. Herein, based on theoretical calculations 62 multiaryl-pyrrole (MAP) systems with spectra ranging from visible region, continuous red shift toward region could be achieved by adjusting type site substituents MAPs. Two descriptors (ΔEgs μgs) were identified exhibiting strong correlations maximum absorption/emission wavelengths, used predict emission spectrum in only if ΔEgs ≤ 2.5 eV μgs 22.55 D. The experimental absorption ten MAPs fully confirmed predictions, biological vivo newly designed MAP23-BBT showed high spatial resolution deep tissue angiography. More importantly, both have shown applicability most reported donor–acceptor–donor-type non-MAP dyes. These results broad implications efficient design

Язык: Английский

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Enhancing NIR‐II Upconversion Monochromatic Emission for Temperature Sensing

Small, Год журнала: 2024, Номер 20(27)

Опубликована: Янв. 28, 2024

The upconversion luminescence (UCL) in the second near-infrared window (NIR-II) is highly attractive due to its excellent performance high-resolution bioimaging, anticounterfeiting, and temperature sensing. However, upconvertion nanoparticles (UCNPs) are normally emitted visible light, potentially impacting imaging quality. Here, a monochromatic Er

Язык: Английский

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NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28011 - 28028

Опубликована: Май 24, 2024

In vivo real-time qualitative and quantitative analysis is essential for the diagnosis treatment of diseases such as tumors. Near-infrared-II (NIR-II, 1000-1700 nm) bioimaging an emerging visualization modality based on fluorescent materials. The advantages NIR-II region materials in terms reduced photon scattering low tissue autofluorescence enable with high resolution increasing depth penetration, thus have great potential analysis. this review, we first summarize recent advances imaging, including probe selection, strategies, imaging. Then, describe detail representative applications to illustrate how fluorescence imaging has become important tool Finally, future possibilities challenges

Язык: Английский

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Brightness Strategies toward NIR-II Emissive Conjugated Materials: Molecular Design, Application, and Future Prospects

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

Recent advances have been made in second near-infrared (NIR-II) fluorescence bioimaging and many related applications because of its advantages deep penetration, high resolution, minimal invasiveness, good dynamic visualization. To achieve high-performance NIR-II bioimaging, various materials probes with bright emission extensively explored the past few years. Among these emissive materials, conjugated polymers small molecules attracted wide interest due to their native biosafety tunable optical performance. This review summarizes brightness strategies available for highlights recent developments bioimaging. A concise, detailed overview molecular design regulatory approaches is provided terms brightness, long wavelengths, superior imaging Then, typical cases which are used as introduced by providing step-by-step examples. Finally, current problems challenges associated accessing briefly discussed, significance future prospects proposed offer helpful guidance development materials.

Язык: Английский

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Anionic Heptamethine Cyanine as Reactive Sulfur Species-Activated Probe: Application of NIR-II Fluorescence Imaging for In Vivo Visualization of Glutathione

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137371 - 137371

Опубликована: Фев. 1, 2025

Язык: Английский

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Pushing Optical Virus Detection to a Single Particle through a High-Q Quasi-bound State in the Continuum in an All-dielectric Metasurface

The Journal of Physical Chemistry Letters, Год журнала: 2023, Номер 14(48), С. 10762 - 10768

Опубликована: Ноя. 27, 2023

Bound states in the continuum (BICs) have emerged as a powerful platform for boosting light–matter interactions because they provide an alternative way of realizing optical resonances with ultrahigh quality factors, accompanied by extreme field confinement. In this work, we realized biosensor harnessing quasi-BIC (qBIC) supported all-dielectric metasurface broken symmetry, whose unit cell is composed silicon cuboid two asymmetric air holes. Thanks to excellent confinement within gap enabled such high-Q qBIC, figure merit (FOM) up 2136.35 RIU–1. Futhermore, demonstrated that can push detection limit few virus particles. Our results may find exciting applications biochemical sensing like COVID-19 ultralow concentrations.

Язык: Английский

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