Abstract
It
is
reported
that
overweight
may
lead
to
accelerated
aging.
However,
there
still
a
lack
of
evidence
on
the
causal
effect
and
We
collected
genetic
variants
associated
with
overweight,
age
proxy
indicators
(telomere
length,
frailty
index
facial
aging),
etc.,
from
genome‐wide
association
studies
datasets.
Then
we
performed
MR
analyses
explore
associations
between
indicators.
were
primarily
conducted
using
inverse
variance
weighted
method,
followed
by
various
sensitivity
validation
analyses.
indicated
significant
telomere
index,
aging
(
β
=
−0.018,
95%
CI
−0.033
−0.003,
p
0.0162;
0.055,
0.030–0.079,
<
0.0001;
0.029,
0.013–0.046,
0.0005
respectively).
Overweight
also
had
negative
causality
longevity
expectancy
(90th
survival
percentile,
−0.220,
−0.323
−0.118,
99th
−0.389,
−0.652
−0.126,
0.0038).
Moreover,
findings
tend
favor
links
body
fat
mass/body
percentage
indicators,
but
not
fat‐free
mass.
This
study
provides
length
decreased,
increased,
increased)
lower
expectancy.
Accordingly,
potential
significance
weight
control
treatment
in
combating
need
be
emphasized.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
Molecular Metabolism,
Год журнала:
2023,
Номер
74, С. 101755 - 101755
Опубликована: Июнь 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Aging
is
a
gradual,
continuous
series
of
natural
changes
in
biological,
physiological,
immunological,
environmental,
psychological,
behavioral,
and
social
processes.
entails
the
immune
system
characterized
by
decrease
thymic
output
naïve
lymphocytes,
an
accumulated
chronic
antigenic
stress
notably
caused
infections
such
as
cytomegalovirus
(CMV),
cell
senescence
with
acquisition
inflammatory
senescence-associated
secretory
phenotype
(SASP).
For
this
reason,
due
to
SASP
originating
from
other
tissues,
aging
commonly
accompanied
low-grade
inflammation,
termed
"inflammaging".
After
decades
accumulating
evidence
regarding
age-related
processes
domain
now
appears
mature
enough
allow
integrative
reinterpretation
old
data.
Here,
we
provide
overview
topics
discussed
recent
workshop
"Aging
Chronic
Inflammation"
which
many
major
players
field
contributed.
We
highlight
advances
systematic
measurement
interpretation
biological
markers
aging,
well
their
implications
for
human
health
longevity
interventions
that
can
be
envisaged
maintain
or
improve
function
older
people.
Ageing Research Reviews,
Год журнала:
2023,
Номер
85, С. 101854 - 101854
Опубликована: Янв. 17, 2023
Telomere
attrition
is
considered
a
hallmark
of
ageing.
Untangling
the
proximate
causes
telomere
may
therefore
reveal
important
aspects
about
ageing
process.
In
landmark
paper
in
2002
Thomas
von
Zglinicki
demonstrated
that
oxidative
stress
accelerates
cell
culture.
next
20
years,
became
firmly
embedded
into
modern
theories
and
attrition.
However,
recent
surge
vivo
studies
reveals
an
inconsistent
pattern
questioning
unequivocal
role
length
(henceforth
referred
to
as
dynamics),
living
organisms.
Here
we
report
results
first
formal
meta-analysis
on
association
between
dynamics
vivo,
representing
37
studies,
4969
individuals,
18,677
correlational
measurements.
The
overall
correlation
markers
was
indistinguishable
from
zero
(r
=
0.027).
This
result
independent
type
marker,
dynamic,
or
taxonomic
group.
measurement
method
affected
analysis
subset
TRF-based
showed
significant
0.09),
supporting
prediction
more
pronounced
short-lived
species
during
adult
life
phase,
when
becomes
apparent.
We
then
performed
additional
interventional
(n
7)
manipulating
stress.
revealed
effect
treatment
(d=0.36).
Our
findings
provide
new
support
for
hypothesis
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114711 - 114711
Опубликована: Апрель 20, 2023
Intervertebral
disc
degeneration
(IVDD)
is
a
frequent
and
intractable
chronic
condition
in
orthopedics
that
causes
enormous
discomfort
patients'
lives
thoughts,
as
well
significant
economic
burden
on
society
the
nation.
As
result,
understanding
pathophysiology
of
IVDD
critical.
The
has
been
linked
to
numerous
variables,
including
oxidative
stress,
apoptosis,
matrix
metalloproteinases,
inflammatory
factors.
Cellular
senescence
recently
attracted
lot
attention
study
age-related
diseases.
It
discovered
intimately
human
senescence,
which
nucleus
pulposus
cell
may
play
role.
Previously,
our
group
did
comprehensive
systematic
clarification
pathogenesis
from
an
immune
perspective
fundamental
upregulation
death
caused
by
imbalance
microenvironment.
In
this
review,
we
will
treat
novelty
point
clarify
further
explore
probable
relationship
between
immunity
along
with
dysregulation
immunological
microenvironment
propose
new
therapeutic
approaches
for
IVDD.
Cell,
Год журнала:
2024,
Номер
187(16), С. 4150 - 4175
Опубликована: Авг. 1, 2024
Cellular
senescence
is
a
cell
fate
triggered
in
response
to
stress
and
characterized
by
stable
cell-cycle
arrest
hypersecretory
state.
It
has
diverse
biological
roles,
ranging
from
tissue
repair
chronic
disease.
The
development
of
new
tools
study
vivo
paved
the
way
for
uncovering
its
physiological
pathological
roles
testing
senescent
cells
as
therapeutic
target.
However,
lack
specific
broadly
applicable
markers
makes
it
difficult
identify
characterize
tissues
living
organisms.
To
address
this,
we
provide
practical
guidelines
called
"minimum
information
cellular
experimentation
vivo"
(MICSE).
presents
an
overview
rodent
tissues,
transgenic
models,
non-mammalian
systems,
human
tumors
their
use
identification
specification
cells.
These
uniform,
state-of-the-art,
accessible
toolset
improve
our
understanding
vivo.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 14279 - 14279
Опубликована: Сен. 19, 2023
Aging
is
considered
the
deterioration
of
physiological
functions
along
with
an
increased
mortality
rate.
This
scientific
review
focuses
on
central
importance
genomic
instability
during
aging
process,
encompassing
a
range
cellular
and
molecular
changes
that
occur
advancing
age.
In
particular,
this
revision
addresses
genetic
epigenetic
alterations
contribute
to
instability,
such
as
telomere
shortening,
DNA
damage
accumulation,
decreased
repair
capacity.
Furthermore,
explores
aging,
including
modifications
histones,
methylation
patterns,
role
non-coding
RNAs.
Finally,
discusses
organization
chromatin
its
contribution
heterochromatin
loss,
remodeling,
in
nucleosome
histone
abundance.
conclusion,
highlights
fundamental
plays
process
underscores
need
for
continued
research
into
these
complex
biological
mechanisms.
