ACS Applied Bio Materials,
Год журнала:
2022,
Номер
5(9), С. 4028 - 4054
Опубликована: Авг. 31, 2022
Research
on
the
role
of
reactive
oxygen
species
(ROS)
in
aging
process
has
advanced
significantly
over
last
two
decades.
In
light
recent
findings,
ROS
takes
part
cells
along
with
contributing
to
various
physiological
signaling
pathways.
Antioxidants
being
cells'
natural
defense
mechanism
against
ROS-mediated
alteration,
play
an
imperative
maintain
intracellular
homeostasis.
Although
complete
understanding
regulated
is
yet
be
fully
comprehended,
current
insights
into
sources
cellular
and
their
correlation
age-related
diseases
are
portrayed
this
review.
addition,
results
effect
antioxidants
homeostasis
as
well
advances
clinical
trials
also
discussed
detail.
The
future
perspective
ROS-antioxidant
dynamics
antiaging
research
marshaled
provide
directions
for
fields.
Periodontitis
is
a
chronic
infectious
disease
caused
by
bacterial
irritation.
As
an
essential
component
of
the
host
immunity,
macrophages
are
highly
plastic
and
play
crucial
role
in
inflammatory
response.
An
appropriate
timely
transition
from
proinflammatory
(M1)
to
anti-inflammatory
(M2)
indispensable
for
treating
periodontitis.
M2
macrophage-derived
exosomes
(M2-exos)
can
actively
target
sites
modulate
immune
microenvironments,
M2-exos
effectively
treat
Excessive
endoplasmic
reticulum
stress
(ER
stress)
unfolded
protein
response
(UPR)
destructive
pathological
characteristics
during
periodontal
bone
loss.
Although
melatonin
has
antioxidant
effects,
studies
focusing
on
ER
modulation
remain
limited.
This
study
fabricates
engineered
loading
with
(Mel@M2-exos)
result,
drive
macrophage
reprogramming
M1
type,
which
resolves
inflammation
accelerated
healing.
Melatonin
released
Mel@M2-exos
rescues
osteogenic
cementogenic
differentiation
capacity
human
ligament
cells
(hPDLCs)
reducing
excessive
UPR.
Injectable
gelatin
methacryloyl
(GelMA)
hydrogels
sustained-release
accelerate
regeneration
rats
ligation-induced
Taken
together,
engineering
promising
candidates
tissue
regeneration.
Antioxidants,
Год журнала:
2023,
Номер
12(2), С. 213 - 213
Опубликована: Янв. 17, 2023
During
recent
decades,
the
complexation
of
organic
ligands
toward
several
metal
ions
s-p
and
d-block
has
been
applied
as
a
plan
to
enhance
its
antioxidant
performance.
Due
their
wide
range
beneficial
impacts,
coordination
compounds
are
widely
used
in
industries,
specifically
medicinal
pharmaceutical
fields.
The
activity
is
generally
improved
by
chelation
consequently
knowing
that
characteristics
both
metals
can
lead
development
greatly
active
compounds.
Chelation
substitute
for
using
traditional
synthetic
antioxidants,
because
chelates
present
benefits,
including
variety
geometry,
oxidation
states,
number,
assist
favor
redox
methods
associated
with
action.
As
well
understanding
best
studied
anti-oxidative
assets
these
compounds,
involved
free
radical
scavenging
process
protecting
human
organisms
from
opposing
effects
radicals.
ability
be
assessed
various
interrelated
systems.
methodological
modification
offers
most
knowledge
on
property
chelates.
Colorimetric
techniques
used,
though
electron
paramagnetic
resonance
(EPR)
an
alternative
metallic
since
color
does
not
affect
results.
Information
about
systems,
restrictions,
permits
dependable
valuation
performance
assisting
application
states
wherever
drugs
required,
such
food
protection,
appropriate
good-packaged
foods,
dietary
supplements,
others.
Because
new
exhaustive
analysis
ligands,
it
become
separate
field
research
chemistry.
investigation
will
respected
providing
foundation
properties
future
tests
building
high-quality
antioxidative
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Апрель 25, 2024
Abstract
Viral
myocarditis,
an
inflammatory
disease
of
the
myocardium,
is
a
significant
cause
sudden
death
in
children
and
young
adults.
The
current
coronavirus
19
pandemic
emphasizes
need
to
understand
pathogenesis
mechanisms
potential
treatment
strategies
for
viral
myocarditis.
Here,
we
found
that
TRIM29
was
highly
induced
by
cardiotropic
viruses
promoted
protein
kinase
RNA-like
endoplasmic
reticulum
(PERK)-mediated
(ER)
stress,
apoptosis,
reactive
oxygen
species
(ROS)
responses
promote
replication
cardiomyocytes
vitro.
deficiency
protected
mice
from
myocarditis
promoting
cardiac
antiviral
functions
reducing
PERK-mediated
inflammation
immunosuppressive
monocytic
myeloid-derived
suppressor
cells
(mMDSC)
vivo.
Mechanistically,
interacted
with
PERK
SUMOylation
maintain
its
stability,
thereby
signaling
pathways.
Finally,
demonstrated
inhibitor
GSK2656157
mitigated
disrupting
TRIM29-PERK
connection,
bolstering
function,
enhancing
responses,
curbing
mMDSC
Our
findings
offer
insight
into
how
exploit
TRIM29-regulated
pathways
instigate
suggesting
targeting
axis
could
mitigate
severity.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Июль 30, 2024
Abstract
Endoplasmic
reticulum
stress
(ERS)
is
a
cellular
response
characterized
by
excessive
contraction
of
the
endoplasmic
(ER).
It
pathological
hallmark
many
diseases,
such
as
diabetes,
obesity,
and
neurodegenerative
diseases.
In
unique
growth
characteristic
varied
microenvironment
cancer,
high
levels
are
necessary
to
maintain
rapid
proliferation
metastasis
tumor
cells.
This
process
closely
related
ERS,
which
enhances
ability
cells
adapt
unfavorable
environments
promotes
malignant
progression
cancer.
this
paper,
we
review
roles
mechanisms
ERS
in
cell
proliferation,
apoptosis,
metastasis,
angiogenesis,
drug
resistance,
metabolism,
immune
response.
We
found
that
can
modulate
via
unfolded
protein
(UPR)
signaling
IRE1,
PERK,
ATF6.
Targeting
may
be
new
strategy
attenuate
protective
effects
on
manuscript
explores
potential
ERS-targeted
therapies,
detailing
through
influences
cancer
highlighting
experimental
clinical
evidence
supporting
these
strategies.
Through
review,
aim
deepen
our
understanding
role
ER
development
provide
insights
for
therapy.
Antioxidants and Redox Signaling,
Год журнала:
2024,
Номер
40(7-9), С. 369 - 432
Опубликована: Фев. 1, 2024
Physiological
levels
of
reactive
oxygen
and
nitrogen
species
(ROS/RNS)
function
as
fundamental
messengers
for
many
cellular
developmental
processes
in
the
cardiovascular
system.
ROS/RNS
involved
cardiac
redox-signaling
originate
from
diverse
sources,
their
are
tightly
controlled
by
key
endogenous
antioxidant
systems
that
counteract
accumulation.
However,
dysregulated
redox-stress
resulting
inefficient
removal
leads
to
inflammation,
mitochondrial
dysfunction,
cell
death,
contributing
development
progression
disease
(CVD).
The
regeneration
of
bone
defects
in
diabetic
patients
still
faces
challenges,
as
the
intrinsic
healing
process
is
impaired
by
hyperglycemia.
Inspired
discovery
that
endoplasmic
reticulum
(ER)
a
state
excessive
stress
and
dysfunction
under
hyperglycemia,
leading
to
osteogenic
disorder,
novel
engineered
exosome
proposed
modulate
ER
homeostasis
for
restoring
function
mesenchymal
stem
cells
(MSCs).
results
indicate
constructed
exosomes
efficiently
regulate
dramatically
facilitate
MSCs
hyperglycemic
niche.
Additionally,
underlying
therapeutic
mechanism
elucidated.
reveal
can
directly
provide
recipient
with
SHP2
activation
mitophagy
elimination
mtROS,
which
immediate
cause
dysfunction.
To
maximize
effect
exosomes,
high-performance
hydrogel
self-healing,
bioadhesive,
exosome-conjugating
properties
applied
encapsulate
vivo
application.
In
vivo,
evaluation
defect
repair
models
demonstrates
delivering
system
intensively
enhance
osteogenesis.
These
findings
crucial
insight
into
design
biological
homeostasis-based
tissue-engineering
strategies
regeneration.
