The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 374 - 403

Опубликована: Март 1, 2023

Язык: Английский

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Myeloid cell-targeted therapies for solid tumours

Nature reviews. Immunology, Год журнала: 2022, Номер 23(2), С. 106 - 120

Опубликована: Июнь 13, 2022

Язык: Английский

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Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июнь 24, 2022

Abstract Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding genomic landscapes and biological functions, the treatment PCa continues improve. Recently, various new classes agents, which include next-generation androgen receptor (AR) signaling inhibitors (abiraterone, enzalutamide, apalutamide, darolutamide), bone-targeting agents (radium-223 chloride, zoledronic acid), poly(ADP-ribose) polymerase (PARP) (olaparib, rucaparib, talazoparib) have been developed treat PCa. Agents targeting other pathways, including cyclin-dependent kinase (CDK)4/6, Ak strain transforming (AKT), wingless-type protein (WNT), epigenetic marks, successively entered clinical trials. Furthermore, prostate-specific membrane antigen (PSMA) such as 177 Lu-PSMA-617 are promising theranostics that could improve both diagnostic accuracy therapeutic efficacy. Advanced studies with immune checkpoint (ICIs) shown limited benefits PCa, whereas subgroups mismatch repair (MMR) or CDK12 inactivation may benefit from ICIs treatment. In this review, we summarized targeted trials their underlying mechanisms, further discussed limitations future directions.

Язык: Английский

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Tumor Microenvironment in Breast Cancer—Updates on Therapeutic Implications and Pathologic Assessment

Cancers, Год журнала: 2021, Номер 13(16), С. 4233 - 4233

Опубликована: Авг. 23, 2021

The tumor microenvironment (TME) in breast cancer comprises local factors, cells, immune cells and stromal of the distant tissues. interaction between their plays important roles proliferation, propagation response to therapies. There is increasing research exploring manipulating non-cancerous components TME for treatment. As now increasingly recognized as a treatment target, its pathologic assessment has become critical component management. latest WHO classification tumors listed pattern/fibrotic focus prognostic factor includes recommendations on infiltrating lymphocytes PD-1/PD-L1 expression, with therapeutic implications. This review dissects cancer, describes relevant prognostication decision, details options that interacts and/or exploits cancer.

Язык: Английский

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Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(22), С. 9926 - 9937

Опубликована: Май 26, 2022

The development of lipid nanoparticle (LNP) formulations for targeting the bone microenvironment holds significant potential nucleic acid therapeutic applications including regeneration, cancer, and hematopoietic stem cell therapies. However, delivery to remains a challenge due several biological barriers, such as low blood flow in bone, blood–bone marrow affinity between drugs minerals, which leads unfavorable dosages microenvironment. Here, we construct series bisphosphonate (BP) lipid-like materials possessing high means overcome barriers deliver mRNA therapeutics efficiently vivo. Following vitro screening BP formulated into LNPs, identified lead BP-LNP formulation, 490BP-C14, with enhanced expression localization mice vivo compared 490-C14 LNPs absence BPs. Moreover, BP-LNPs secretion morphogenetic protein-2 from upon intravenous administration. These results demonstrate microenvironment, could potentially be utilized range regenerative medicine, protein replacement, gene editing

Язык: Английский

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Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Авг. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Язык: Английский

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Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

Research, Год журнала: 2023, Номер 6

Опубликована: Янв. 1, 2023

Rapid and effective repair of injured or diseased bone defects remains a major challenge due to shortages implants. Smart hydrogels that respond internal external stimuli achieve therapeutic actions in spatially temporally controlled manner have recently attracted much attention for therapy regeneration. These can be modified by introducing responsive moieties embedding nanoparticles increase their capacity repair. Under specific stimuli, smart variable, programmable, controllable changes on demand modulate the microenvironment promoting healing. In this review, we highlight advantages summarize materials, gelation methods, properties. Then, overview recent advances developing biochemical signals, electromagnetic energy, physical including single, dual, multiple types enable physiological pathological modulating microenvironment. discuss current challenges future perspectives regarding clinical translation hydrogels.

Язык: Английский

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Nanomaterials for bone metastasis

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 640 - 651

Опубликована: Авг. 1, 2024

Язык: Английский

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Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 1, 2024

Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from tissues and can be classified into primary secondary types. Due the specificity of microenvironment, results traditional means treating tumors often unsatisfactory, so there is an urgent need develop new treatments for malignant tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis treatment. Nanoparticles (NPs) gained significant attention due their versatility, making them highly suitable applications tissue engineering, advanced imaging techniques, targeted drug delivery. For diagnosis, NPs enhance contrast sensitivity by integrating targeting ligands, significantly improve specific recognition localization tumor cells early detection. treatment, enable delivery, increasing accumulation at sites while reducing systemic toxicity. In conclusion, understanding microenvironment using unique properties holds promise improving disease management, enhancing treatment outcomes, ultimately quality life patients Further research development will undoubtedly contribute advancement personalized medicine field oncology.

Язык: Английский

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Targeting initial tumour–osteoclast spatiotemporal interaction to prevent bone metastasis

Nature Nanotechnology, Год журнала: 2024, Номер 19(7), С. 1044 - 1054

Опубликована: Март 18, 2024

Язык: Английский

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