Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160620 - 160620
Опубликована: Фев. 1, 2025
Язык: Английский
Giant, Год журнала: 2023, Номер 17, С. 100209 - 100209
Опубликована: Ноя. 15, 2023
Additive manufacturing (AM) aka three-dimensional (3D) printing has been a well-established and unparalleled technology, which is expanding the boundaries of materials science exhibiting an enormous potential to fabricate intricate geometries for healthcare, electronics, construction sectors. In contemporary era, combination AM technology stimuli-responsive hydrogels (SRHs) helps create dynamic functional structures with extreme accuracy, are capable changing their shape, functional, or mechanical properties in response environmental cues such as humidity, heat, light, pH, magnetic field, electric etc. 3D SRHs permits creation on-demand dynamically controllable shapes excellent control over various self-repair, self-assembly, multi-functionality, These accelerate researchers think unthinkable applications. Additively manufactured objects have shown applications like tissue engineering, drug delivery, soft robots, sensors, other biomedical devices. The current review provides recent progress SRHs, more focus on techniques, stimuli mechanisms, shape morphing behaviors, Finally, trends future roadmap additively smart different also presented, will be helpful research. This holds great promise providing fundamental knowledge about diverse
Язык: Английский
Процитировано
71
Materials Today Bio, Год журнала: 2023, Номер 20, С. 100640 - 100640
Опубликована: Апрель 23, 2023
Hydrogels resemble natural extracellular matrices and have been widely studied for biomedical applications. Nano-crosslinked dynamic hydrogels combine the injectability self-healing property of with versatility nanomaterials exhibit unique advantages. The incorporation as crosslinkers can improve mechanical properties (strength, injectability, shear-thinning properties) by reinforcing skeleton endowing them multifunctionality. functional that respond to external stimuli (such pH, heat, light, electromagnetic stimuli) photothermal properties, antimicrobial stone regeneration abilities, or tissue repair abilities constructed through reversible covalent crosslinking strategies physical strategies. possible cytotoxicity incorporated be reduced. Nanomaterial show excellent biocompatibility facilitate cell proliferation differentiation This review introduces different nano-crosslinked in medical field, from fabrication application. In this review, hydrogel fabrication, such metals metallic oxides, nanoclays, carbon-based nanomaterials, black phosphorus (BP), polymers, liposomes, are discussed. We also introduce method commonly used nanodynamic hydrogels. Finally, applications presented. hope summary will help researchers related research fields quickly understand develop more preparation promote their development
Язык: Английский
Процитировано
51
Small, Год журнала: 2024, Номер 20(24)
Опубликована: Янв. 2, 2024
Abstract In view of the increased levels reactive oxygen species (ROS) that disturb osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs), repair diabetic defects remains a great challenge. Herein, factor‐free hydrogel is reported with ROS scavenging and responsive degradation properties for enhanced healing. These hydrogels contain ROS‐cleavable thioketal (TK) linkers ultraviolet (UV)‐responsive norbornene (NB) groups conjugated 8‐arm PEG macromers, which are formed via UV crosslinking‐mediated gelation. Upon reacting high in defect microenvironment, TK destroyed, allowing hydrogels, promotes migration BMSCs. Moreover, reduced through hydrogel‐mediated to reverse BMSC from adipogenic phenotype. As such, favorable microenvironment created after simultaneous degradation, leading effective mouse models, even without addition growth factors. Thus, this study presents platform regulates stromal engineering.
Язык: Английский
Процитировано
30
Composites Part B Engineering, Год журнала: 2024, Номер 274, С. 111282 - 111282
Опубликована: Фев. 5, 2024
Язык: Английский
Процитировано
17
Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 786 - 796
Опубликована: Янв. 25, 2025
Язык: Английский
Процитировано
2
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155131 - 155131
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
13
Advanced Science, Год журнала: 2024, Номер 11(20)
Опубликована: Март 9, 2024
Abstract Inflammation‐responsive hydrogels loaded with therapeutic factors are effective biomaterials for bone tissue engineering and regenerative medicine. In this study, a matrix metalloproteinase (MMP)‐responsive injectable hydrogel is constructed by integrating an MMP‐cleavable peptide (pp) into covalent tetra‐armed poly‐(ethylene glycol) (PEG) network precise drug release upon inflammation stimulation. To establish pro‐regenerative environment, phosphatidylserine (PS) encapsulated scaffold to form the PEG‐pp‐PS network, which could be triggered MMP large amount of PS during early stage retain persistently until later repair. The found mechanically biologically adaptable complex defect area. vivo in vitro studies further demonstrated ability transform macrophages anti‐inflammatory M2 phenotype promote osteogenic differentiation, thus, resulting new regeneration. Therefore, study provides facile, safe, promising cell‐free strategy on simultaneous immunoregulation osteoinduction engineering.
Язык: Английский
Процитировано
11
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 266, С. 131337 - 131337
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
10
Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(3), С. 100911 - 100911
Опубликована: Апрель 14, 2024
Precision therapy has become the preferred choice attributed to optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over past few years, sprayable or injectable thermosensitive hydrogels have exhibited high potential. These can be applied as cell-growing scaffolds drug-releasing reservoirs by simply mixing a free-flowing sol phase at room temperature. Inspired their unique properties, been widely delivery treatment platforms for precision medicine. In this review, state-of-the-art developments are investigated, which covers from thermo-gelling mechanisms main components biomedical applications, including wound healing, anti-tumor activity, osteogenesis, periodontal, sinonasal ophthalmic diseases. The most promising applications trends of also discussed light features.
Язык: Английский
Процитировано
10
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Май 28, 2024
The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with
Язык: Английский
Процитировано
10