ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Март 21, 2024

Reactive oxygen species (ROS) plays important roles in living organisms. While ROS is a double-edged sword, which can eliminate drug-resistant bacteria, but excessive levels cause oxidative damage to cells. A core-shell nanozyme, CeO

Язык: Английский

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Near‐Infrared Light‐Triggered MXene Nanocomposite for Tumor‐Specific Mild Photothermal‐Enhanced Chemodynamic Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Май 20, 2024

Abstract Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO 2 /GA) developed to synergistically combine mild PTT chemodynamic (CDT) remarkably tumor eradication without any notable tissue damage. Under irradiation NIR light, effectively enhances by suppressing HSP90 expression through release gambogic acid (GA) due excellent performance Ti 3 C nanosheets well tumor‐targeting ability biocompatibility surface‐modified FA‐PEG‐SH. The copper‐based catalyst CuO in this system releases Cu 2+ acid‐triggered manner within microenvironment, activating Fenton‐like reaction generate hydroxyl radicals, simultaneous production H O serves alleviate deficiency endogenous tumor. Overall, current work showcases remarkable synergistic anticancer effect CDT, also proposes new avenues research utilizing nanomaterials treatment.

Язык: Английский

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A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells

Biomaterials, Год журнала: 2024, Номер 313, С. 122763 - 122763

Опубликована: Авг. 17, 2024

Язык: Английский

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Multifunctional microwave absorption materials: construction strategies and functional applications

Materials Horizons, Год журнала: 2024, Номер 11(23), С. 5874 - 5894

Опубликована: Янв. 1, 2024

Classification and multifunctional scalability of advanced microwave absorbing materials.

Язык: Английский

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Engineered macrophage-derived cellular vesicles for NIR-II fluorescence imaging-guided precise cancer photo-immunotherapy

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 235, С. 113770 - 113770

Опубликована: Фев. 1, 2024

Язык: Английский

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Tumor microenvironment targeted nano-drug delivery systems for multidrug resistant tumor therapy

Theranostics, Год журнала: 2025, Номер 15(5), С. 1689 - 1714

Опубликована: Янв. 2, 2025

In recent years, nano-drug delivery systems (Nano-DDS) that target the tumor microenvironment (TME) to overcome multidrug resistance (MDR) have become a research hotspot in field of cancer therapy. By precisely targeting TME and regulating its unique pathological features, such as hypoxia, weakly acidic pH, abnormally expressed proteins, etc., these Nano-DDS enable effective therapeutic agents reversal MDR. This scientific community is increasing investment development diversified exploring their anti-drug potential. Therefore, it particularly important conduct comprehensive review progress TME-targeted years. After brief introduction MDR, design principle structure liposomes, polymer micelles inorganic nanocarriers are focused on, characteristics described. It also demonstrates how break through MDR treatment various mechanisms, discusses synthetic innovation, results overcoming mechanisms. The was concluded with deliberations on key challenges future outlooks

Язык: Английский

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Defect Engineering in Biomedical Sciences

Advanced Materials, Год журнала: 2023, Номер 35(38)

Опубликована: Июнь 4, 2023

Abstract With the promotion of nanochemistry research, large numbers nanomaterials have been applied in vivo to produce desirable cytotoxic substances response endogenous or exogenous stimuli for achieving disease‐specific therapy. However, performance is a critical issue that difficult improve and optimize under biological conditions. Defect‐engineered nanoparticles become most researched hot materials biomedical applications recently due their excellent physicochemical properties, such as optical properties redox reaction capabilities. Importantly, can be easily adjusted by regulating type concentration defects without requiring other complex designs. Therefore, this tutorial review focuses on defect engineering briefly discusses classification, introduction strategies, characterization techniques. Several representative defective are especially discussed order reveal relationship between properties. A series disease treatment strategies based engineered summarized. By summarizing design application nanomaterials, simple but effective methodology provided researchers therapeutic effects nanomaterial‐based platforms from science perspective.

Язык: Английский

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Tumor‐Specific Peroxynitrite Overproduction Disrupts Metabolic Homeostasis for Sensitizing Melanoma Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(29)

Опубликована: Май 3, 2023

Tumor cells elicit metabolic reprogramming to establish an immunosuppressive tumor microenvironment (TME) for escaping from immunosurveillance. Therefore, interrupting the adaptation of may be a promising strategy TME immunomodulation, favoring immunotherapy. In this work, tumor-specific peroxynitrite nanogenerator APAP-P-NO is constructed that can selectively disrupt homeostasis in melanoma cells. Stimulated by melanoma-characteristic acid, glutathione, and tyrosinase, efficiently generate through situ coupling produced superoxide anion released nitric oxide. Metabolomics profiling reveals accumulated induces great decrease metabolites tricarboxylic acid cycle. Meanwhile, glycolysis-produced lactate drops sharply both intracellularly extracellularly under stress. Mechanistically, impairs activity glyceraldehyde-3-phosphate dehydrogenase glucose metabolism S-nitrosylation. The alterations effectively reverse evoke potent antitumor immune responses, including polarization M2-like macrophages M1phenotype, reduction myeloid-derived suppressor regulatory T cells, restoration CD8+ cell infiltration. Combining with anti-PD-L1 achieves significant inhibition against primary metastatic melanomas without systemic toxicities. Collectively, overproduction approach developed possible mechanism peroxynitrite-mediated immunomodulation explored, providing new facilitating immunotherapy sensitivity.

Язык: Английский

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A Booster for Radiofrequency Ablation: Advanced Adjuvant Therapy via In Situ Nanovaccine Synergized with Anti-programmed Death Ligand 1 Immunotherapy for Systemically Constraining Hepatocellular Carcinoma

ACS Nano, Год журнала: 2023, Номер 17(19), С. 19441 - 19458

Опубликована: Сен. 21, 2023

Radiofrequency ablation (RFA) is one of the most common minimally invasive techniques for treating hepatocellular carcinoma (HCC), which could destroy tumors through hyperthermia and generate massive tumor-associated antigens (TAAs). However, residual malignant tissues or small satellite lesions are hard to eliminate, generally resulting in metastases recurrence. Herein, an advanced situ nanovaccine formed by layered double hydroxides carrying cGAMP (STING agonist) (LDHs-cGAMP) adsorbed TAAs was designed potentiate RFA-induced antitumor immune response. As-prepared LDHs-cGAMP effectively enter cancerous cells, inducing a stronger type I interferon (IFN-I) After further adsorption TAAs, generated sustained stimulation efficiently promoted activation dendritic cells (DCs). Notably, infiltrations cytotoxic lymphocytes (CTLs) activated DCs tumor lymph nodes were significantly enhanced after treatment, distinctly inhibited primary, distant, metastasis liver cancer. Furthermore, such strategy greatly changed microenvironment response efficiency anti-programmed death ligand 1 (αPD-L1) immunotherapy, arresting poorly immunogenic hepa1-6 cancer progression. These findings demonstrate potential as booster RFA therapy provide promising vaccination strategy.

Язык: Английский

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H₂S-Reactivating Antitumor Immune Response after Microwave Thermal Therapy for Long-Term Tumor Suppression

ACS Nano, Год журнала: 2023, Номер 17(19), С. 19242 - 19253

Опубликована: Окт. 2, 2023

Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known, with advantages like deep penetration, minimal invasion, repeatable operation, and low interference from bone gas. However, microwave (MW) not selective against tumors, residual tumors after incomplete ablation will generate immunosuppression, ultimately making prone to recurrence metastasis. Herein, a nano-immunomodulator (Bi-MOF-l-Cys@PEG@HA, BMCPH) proposed reverse immunosuppression reactivate antitumor immune effect through responsively releasing H2S in tumor cells for improving MWTT. Under MW irradiation, BMCPH mediate MWTT ablate release l-cysteine (l-Cys) react highly expressed cystathionine β-synthase H2S. The generated can inhibit accumulation myeloid-derived suppressor (MDSCs) promote expression cytotoxic T lymphocytes (CTLs). Moreover, Bi-MOF also scavenge reactive oxygen species (ROS), major means MDSCs-mediated further weaken immunosuppressive effect. Simultaneously, surface-covered HA gather CTLs around enhance response. This nano gas immunomodulator provides an idea sensitive tunable unstable molecules at sites. strategy response introduces direction reduce risk metastasis ablation.

Язык: Английский

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