Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 8, 2025
Abstract
Diabetic
wounds
experience
a
hyperglycemic,
hypoxic
environment,
combined
with
ongoing
oxidative
stress
and
inflammatory
imbalances,
significantly
disrupts
normal
healing
process.
Advanced
hydrogels
have
been
considered
one
of
the
most
exciting
medical
biomaterials
for
potential
in
healing.
Herein,
novel
conductive
hydrogel
(HEPP),
designed
to
release
nanozyme
(PTPPG)
response
its
microenvironment,
was
created
facilitate
glucose
(Glu)
catabolism.
Furthermore,
HEPP
integrates
photodynamic
therapy
(PDT),
photothermal
(PTT),
self‐cascading
reactive
oxygen
species
(ROS)
prevent
bacterial
infections
while
ensuring
continuous
supply
(O
2
)
wound.
The
not
only
adeptly
controls
high
ROS
levels,
but
also
enhances
regulation
inflammation
wound
area
via
electrical
stimulation
(ES),
thereby
promoting
that
is
supported
by
immune
response.
Studies
conducted
vitro,
along
transcriptomic
analyses,
indicate
ES
primarily
mitigates
regulating
Interleukin‐6
(IL‐6)
tumor
necrosis
factor‐α
(TNF‐α).
effects
are
connected
their
impact
on
TNF
signaling
pathways.
By
reducing
formation
employing
effectively
lessen
inflammation,
this
approach
offers
an
innovative
method
manage
complicated
diabetic
wounds,
ulcers,
range
conditions
linked
infections.
Abstract
Wound
healing
is
a
complex
process
that
involves
multiple
stages
and
susceptible
to
various
challenges,
such
as
infection,
insufficient
blood
flow,
the
body's
inadequate
response
process,
which
can
be
life‐threatening
for
patient.
In
current
medical
landscape,
traditional
treatments
often
struggle
meet
high
standards
of
modern
care.
Therefore,
it
crucial
actively
explore
develop
new
drugs
or
advanced
technologies
enhance
bacterially
infected
wounds.
recent
years,
several
physical
methods
effectively
accelerate
wound
have
garnered
widespread
attention
interest.
Among
these,
Photothermal
therapy
(PTT)
has
been
extensively
utilized
in
treatment
bacterial
infections
due
its
non‐invasive,
low
toxicity,
ease
use.
The
photothermal
agents
(PTAs)
serve
core
material
PTT,
their
efficacy
significantly
influenced
by
specific
PTAs
employed.
Selecting
appropriate
essential
achieving
desired
therapeutic
effect.
This
relies
on
PTAs's
ability
efficiently
convert
wavelengths
light
energy
into
heat
upon
absorption,
thereby
generating
thermal
effect
at
site.
Consequently,
properties
PTAs,
including
conversion
efficiency,
biocompatibility,
stability
within
organism,
are
critical
factors
determine
outcome.
review
introduces
organic,
inorganic,
organic‐inorganic
hybrid
PTT
healing,
highlighting
main
applications
management
years.
Finally,
we
briefly
discuss
limitations
prospects
this
field.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Июль 15, 2024
Macrophage
immunotherapy
represents
an
emerging
therapeutic
approach
aimed
at
modulating
the
immune
response
to
alleviate
disease
symptoms.
Nanomaterials
(NMs)
have
been
engineered
monitor
macrophage
metabolism,
enabling
evaluation
of
progression
and
replication
intricate
physiological
signal
patterns.
They
achieve
this
either
directly
or
by
delivering
regulatory
signals,
thereby
mapping
phenotype
effector
functions
through
metabolic
repurposing
customize
fate
for
therapy.
However,
a
comprehensive
summary
regarding
NM-mediated
visualization
coordinated
rewiring
maintain
phenotypic
equilibrium
is
currently
lacking.
This
review
aims
address
gap
outlining
recent
advancements
in
NM-based
immunotherapy.
We
initially
explore
relationship
between
polarization,
disease,
before
delving
into
NM
innovations
that
visualize
activity
elucidate
onset
fine-tune
its
remodeling
macrophage-centered
Finally,
we
discuss
prospects
challenges
immunotherapy,
aiming
accelerate
clinical
translation.
anticipate
will
serve
as
valuable
reference
researchers
seeking
leverage
novel
intervention-matched
immunomodulators
macrophages
other
fields
engineering.
Biomedical Materials,
Год журнала:
2024,
Номер
19(5), С. 052001 - 052001
Опубликована: Июль 8, 2024
Abstract
Wound
healing
is
a
critical
but
complex
biological
process
of
skin
tissue
repair
and
regeneration
resulting
from
various
systems
working
together
at
the
cellular
molecular
levels.
Quick
wound
problems
associated
with
traditional
techniques
are
being
overcome
multifunctional
materials.
Over
time,
this
research
area
has
drawn
significant
attention.
Metal-organic
frameworks
(MOFs),
owning
to
their
peculiar
physicochemical
characteristics,
now
considered
promising
class
well-suited
porous
materials
for
in
addition
other
applications.
This
detailed
literature
review
provides
an
overview
latest
developments
MOFs
We
have
discussed
synthesis,
essential
biomedical
properties,
wound-healing
mechanism,
MOF-based
dressing
materials,
The
possible
major
challenges
limitations
been
discussed,
along
conclusions
future
perspectives.
addresses
MOFs-based
several
angles
covers
most
current
subject.
readers
may
discover
how
advanced
discipline
by
producing
more
inventive,
useful,
successful
dressings.
It
influences
development
generations
biomaterials
wounds.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 3, 2024
Abstract
Intelligent
antibacterial
agent
with
controllable
activities
adaptive
to
the
wound
microenvironment
is
appealing
reduce
drug
resistance
and
enhance
efficiency.
In
this
study,
celery
chosen
as
carbon
source
construct
celery‐based
dots
(CECDs)
double
activities,
i.e.,
reactive
oxygen
species
(ROS)‐production
ROS‐clearance
activities.
The
ROS‐production
capability
of
CECDs
dependent
on
oxidase
(OXD)‐mimicking
activity,
which
only
photo‐activated
thus
artificially
controlled
by
light
avoid
production
excess
ROS.
Meanwhile,
optimal
OXD‐mimicking
activity
occurrs
at
pH
5,
close
microenvironmental
bacterial
infection
site,
will
efficacy.
On
other
hand,
exhibit
antioxidant
neutral
or
weak
alkaline
pH,
assist
healing
wound.
Thus,
conversion
ability
can
be
dynamically
intelligently
switched
automatically
different
stages
treatment
(from
acid
neutral/weak
basic).
proposed
exert
adorable
selective
against
Gram‐positive
bacteria
satisfactory
therapeutic
effect
infected
mice.
This
study
paves
a
new
avenue
design
intelligent
nanoagent
sensitive
condition,
reducing
assisting
precise
medicine.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Long-term
inflammation
and
persistent
bacterial
infection
are
primary
contributors
to
unhealed
chronic
wounds.
The
use
of
conventional
antibiotics
often
leads
bacteria
drug
resistance,
diminishing
wound
healing
effectiveness.
Nanozymes
have
become
a
promising
alternative
antimicrobial
materials
due
their
low
cost,
easy
synthesis,
good
stability.
Herein,
we
develop
novel
sprayable
hydrogel
based
on
carboxymethyl
chitosan
(CMCS)
oxidized
hyaluronic
acid
(OHA),
incorporating
Au
nanoparticle-carbon
nitride
(AuNPs-C3N4)
nanozyme,
glucose,
Mn2+
for
bacteria-infected
healing.
forms
rapidly
in
situ
upon
spraying
gradually
degrades
the
area,
releasing
AuNPs-C3N4
which
exhibits
robust
glucose
oxidase-like
(GOx-like)
activity,
initiating
comprehensive
catalytic
cascade
through
Mn2+-mediated
Fenton-like
reaction
that
generates
hydroxyl
radicals
(•OH)
eliminate
Staphylococcus
aureus
(S.
aureus)
Methicillin-resistant
S.
(MRSA).
Computational
results
indicate
interactions
between
AuNPs
g-C3N4
maximize
synergistic
effects
heterojunction,
improving
O2
adsorption
facilitating
electron-O2
optimize
activity.
Further
experiments
demonstrate
can
cover
wounds
situ,
while
CMCS
promotes
collagen
production
fibroblast
proliferation,
offering
viable
strategy
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 24, 2025
Exosomes-loaded
hydrogels
have
potential
value
in
wound
treatment.
Current
studies
focus
on
improving
hydrogels'
biocompatibility
and
optimizing
different
stem
cell-derived
exosomes
for
better
therapeutic
effect.
Herein,
we
present
a
novel
biocompatible
recombinant
human
collagen
(RHC)
hydrogel
loading
with
MSCs-derived
promoting
healing.
We
modify
the
RHC
methacrylate
anhydride
(MA)
at
optimal
concentration,
generating
(RHCMA)
ideal
physiochemical
properties
exosome
delivery
(MSC-exos@RHCMA).
Exosomes
derived
from
adipose-derived
MSCs
(ADSC-exos),
bone
marrow-derived
(BMSC-exos)
umbilical
cord
(ucMSC-exos)
are
harvested
culture
supernatants
loaded
into
RHCMA,
respectively.
These
three
systems
exhibit
desired
sustained
release
features,
can
significantly
improve
cell
proliferation
migration.
In
addition,
these
MSC-exos@RHCMAs
show
excellent
performance
treating
wounds
of
rats.
Notably,
demonstrated
that
healing
effect
occurs
best
under
treatment
ucMSC-exos@RHCMA,
following
inflammatory
resolution,
angiogenesis,
formation.
results
would
supply
important
clinical
application
MSC-exos
future.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Окт. 21, 2024
The
rational
utilization
of
ROS
is
key
to
treating
infected
wounds.
Exogenous
can
destroy
bacterial
structures,
quickly
kill
bacteria,
and
inhibit
secondary
infections.
However,
excess
at
the
wound
will
cause
a
inflammatory
response.
Acute
infections
exacerbate
this
damage
by
increasing
endogenous
ROS,
complicating
maintenance
homeostasis.
Therefore,
regulating
balance
production
scavenging
in
wounds
has
emerged
as
promising
strategy
for
treatment.
Conventional
balancing
platforms
are
mostly
based
on
"
all
one"
functional
superposition
lack
self-adaptability
integration.
To
subvert
conventional
strategy,
study
proposes
"one
all"
self-adaptive
integrated
photodynamic
therapy
(PDT)-antioxidant
model
actively
regulate
balance.
A
gelatin-hyaluronic
acid
hydrogel
embedded
with
Se-modified
cerium
dioxide
nanoparticles
(Gel-HA-Se@CeO2
NPs)
designed
Se@CeO2
NPs
serve
both
nanoenzymes
photosensitizers(PS).
As
nanoenzymes,
they
exhibit
catalase
superoxide
dismutase
activities,
converting
hydrogen
peroxide
anions
into
oxygen.
PS,
it
synergizes
oxygen
under
NIR
irradiation
rapidly
produce
singlet
Additionally,
Se
modification
enhances
PDT
effects
disrupting
antioxidant
systems.
In
vitro
vivo
experiments
revealed
that
platform
polarizes
M1-type
macrophages
M2-type
macrophages,
altering
microenvironment
from
proinflammatory
prohealing.
RNA
sequencing
accelerated
reconstruction
vascular
network
activating
PI3K/AKT
pathway
VEGF
secretion.This
believed
be
beneficial
not
only
but
also
other
conditions
involve
regulation
reactive
species,
such
tumors
