An Intelligent and Conductive Hydrogel with Multiresponsive and ROS Scavenging Properties for Infection Prevention and Anti‐Inflammatory Treatment Assisted by Electrical Stimulation for Diabetic Wound DOI Creative Commons
Tao Zhang,

Zongwu Meng,

Haoyu Yu

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Abstract Diabetic wounds experience a hyperglycemic, hypoxic environment, combined with ongoing oxidative stress and inflammatory imbalances, significantly disrupts normal healing process. Advanced hydrogels have been considered one of the most exciting medical biomaterials for potential in healing. Herein, novel conductive hydrogel (HEPP), designed to release nanozyme (PTPPG) response its microenvironment, was created facilitate glucose (Glu) catabolism. Furthermore, HEPP integrates photodynamic therapy (PDT), photothermal (PTT), self‐cascading reactive oxygen species (ROS) prevent bacterial infections while ensuring continuous supply (O 2 ) wound. The not only adeptly controls high ROS levels, but also enhances regulation inflammation wound area via electrical stimulation (ES), thereby promoting that is supported by immune response. Studies conducted vitro, along transcriptomic analyses, indicate ES primarily mitigates regulating Interleukin‐6 (IL‐6) tumor necrosis factor‐α (TNF‐α). effects are connected their impact on TNF signaling pathways. By reducing formation employing effectively lessen inflammation, this approach offers an innovative method manage complicated diabetic wounds, ulcers, range conditions linked infections.

Язык: Английский

Engineering in NIR‐responsive photothermal materials and their application in wound healing administration DOI Creative Commons
A. Bassam, Meng-Xuan Du, Yuan Li

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.

Язык: Английский

Процитировано

5

Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications DOI Creative Commons

Tingting Meng,

Danfeng He,

Zhuolei Han

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 15, 2024

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have been engineered monitor macrophage metabolism, enabling evaluation of progression and replication intricate physiological signal patterns. They achieve this either directly or by delivering regulatory signals, thereby mapping phenotype effector functions through metabolic repurposing customize fate for therapy. However, a comprehensive summary regarding NM-mediated visualization coordinated rewiring maintain phenotypic equilibrium is currently lacking. This review aims address gap outlining recent advancements in NM-based immunotherapy. We initially explore relationship between polarization, disease, before delving into NM innovations that visualize activity elucidate onset fine-tune its remodeling macrophage-centered Finally, we discuss prospects challenges immunotherapy, aiming accelerate clinical translation. anticipate will serve as valuable reference researchers seeking leverage novel intervention-matched immunomodulators macrophages other fields engineering.

Язык: Английский

Процитировано

13

Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing DOI
Muhammad Umar Aslam Khan,

Muhammad Azhar Aslam,

Tooba Yasin

и другие.

Biomedical Materials, Год журнала: 2024, Номер 19(5), С. 052001 - 052001

Опубликована: Июль 8, 2024

Abstract Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular molecular levels. Quick wound problems associated with traditional techniques are being overcome multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, now considered promising class well-suited porous materials for in addition other applications. This detailed literature review provides an overview latest developments MOFs We have discussed synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, The possible major challenges limitations been discussed, along conclusions future perspectives. addresses MOFs-based several angles covers most current subject. readers may discover how advanced discipline by producing more inventive, useful, successful dressings. It influences development generations biomaterials wounds.

Язык: Английский

Процитировано

11

Intelligent Carbon Dots with Switchable Photo‐Activated Oxidase‐Mimicking Activity and pH Responsive Antioxidant Activity Adaptive to the Wound Microenvironment for Selective Antibacterial Therapy DOI Creative Commons
He Li, Zhi Li,

Meiqi Gu

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Abstract Intelligent antibacterial agent with controllable activities adaptive to the wound microenvironment is appealing reduce drug resistance and enhance efficiency. In this study, celery chosen as carbon source construct celery‐based dots (CECDs) double activities, i.e., reactive oxygen species (ROS)‐production ROS‐clearance activities. The ROS‐production capability of CECDs dependent on oxidase (OXD)‐mimicking activity, which only photo‐activated thus artificially controlled by light avoid production excess ROS. Meanwhile, optimal OXD‐mimicking activity occurrs at pH 5, close microenvironmental bacterial infection site, will efficacy. On other hand, exhibit antioxidant neutral or weak alkaline pH, assist healing wound. Thus, conversion ability can be dynamically intelligently switched automatically different stages treatment (from acid neutral/weak basic). proposed exert adorable selective against Gram‐positive bacteria satisfactory therapeutic effect infected mice. This study paves a new avenue design intelligent nanoagent sensitive condition, reducing assisting precise medicine.

Язык: Английский

Процитировано

10

Sprayable Hydrogel for pH-Responsive Nanozyme-Derived Bacteria-Infected Wound Healing DOI

Furong Chao,

Chengliang Cao, Yin Xu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative antimicrobial materials due their low cost, easy synthesis, good stability. Herein, we develop novel sprayable hydrogel based on carboxymethyl chitosan (CMCS) oxidized hyaluronic acid (OHA), incorporating Au nanoparticle-carbon nitride (AuNPs-C3N4) nanozyme, glucose, Mn2+ for bacteria-infected healing. forms rapidly in situ upon spraying gradually degrades the area, releasing AuNPs-C3N4 which exhibits robust glucose oxidase-like (GOx-like) activity, initiating comprehensive catalytic cascade through Mn2+-mediated Fenton-like reaction that generates hydroxyl radicals (•OH) eliminate Staphylococcus aureus (S. aureus) Methicillin-resistant S. (MRSA). Computational results indicate interactions between AuNPs g-C3N4 maximize synergistic effects heterojunction, improving O2 adsorption facilitating electron-O2 optimize activity. Further experiments demonstrate can cover wounds situ, while CMCS promotes collagen production fibroblast proliferation, offering viable strategy

Язык: Английский

Процитировано

2

Recombinant human collagen hydrogels with different stem cell-derived exosomes encapsulation for wound treatment DOI Creative Commons

Xiaoman Zeng,

Jingjing Gan, Danqing Huang

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 24, 2025

Exosomes-loaded hydrogels have potential value in wound treatment. Current studies focus on improving hydrogels' biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Herein, we present a novel biocompatible recombinant human collagen (RHC) hydrogel loading with MSCs-derived promoting healing. We modify the RHC methacrylate anhydride (MA) at optimal concentration, generating (RHCMA) ideal physiochemical properties exosome delivery (MSC-exos@RHCMA). Exosomes derived from adipose-derived MSCs (ADSC-exos), bone marrow-derived (BMSC-exos) umbilical cord (ucMSC-exos) are harvested culture supernatants loaded into RHCMA, respectively. These three systems exhibit desired sustained release features, can significantly improve cell proliferation migration. In addition, these MSC-exos@RHCMAs show excellent performance treating wounds of rats. Notably, demonstrated that healing effect occurs best under treatment ucMSC-exos@RHCMA, following inflammatory resolution, angiogenesis, formation. results would supply important clinical application MSC-exos future.

Язык: Английский

Процитировано

2

Enhanced antioxidant activity of CeO2/Ti3C2Tx nanocomposites for cardiovascular protection DOI
Yanjie Hou,

Jialing Liu,

Guannan Zhang

и другие.

Inorganic Chemistry Communications, Год журнала: 2025, Номер 174, С. 114006 - 114006

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

1

Chitosan-based hydrogel incorporated with polydopamine and protoporphyrin for photothermal-oxidation sterilization of bacteria-infected wound therapy DOI
Xiao Wang, Xiaojing Zhang, Wenjing Zhao

и другие.

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 89 - 100

Опубликована: Сен. 13, 2024

Язык: Английский

Процитировано

8

Advancements in nanozymes research for the management of chronic wounds DOI

Duoduo Chen,

Guoxin Tan,

Shujian Tian

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157299 - 157299

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

8

Collaboration in Contradiction: Self‐Adaptive Synergistic ROS Generation and Scavenge Balancing Strategies Used for the Infected Wounds Treatment DOI
Mengtian Wang, Yangkun Liu, Shuqing Yang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Окт. 21, 2024

The rational utilization of ROS is key to treating infected wounds. Exogenous can destroy bacterial structures, quickly kill bacteria, and inhibit secondary infections. However, excess at the wound will cause a inflammatory response. Acute infections exacerbate this damage by increasing endogenous ROS, complicating maintenance homeostasis. Therefore, regulating balance production scavenging in wounds has emerged as promising strategy for treatment. Conventional balancing platforms are mostly based on " all one" functional superposition lack self-adaptability integration. To subvert conventional strategy, study proposes "one all" self-adaptive integrated photodynamic therapy (PDT)-antioxidant model actively regulate balance. A gelatin-hyaluronic acid hydrogel embedded with Se-modified cerium dioxide nanoparticles (Gel-HA-Se@CeO2 NPs) designed Se@CeO2 NPs serve both nanoenzymes photosensitizers(PS). As nanoenzymes, they exhibit catalase superoxide dismutase activities, converting hydrogen peroxide anions into oxygen. PS, it synergizes oxygen under NIR irradiation rapidly produce singlet Additionally, Se modification enhances PDT effects disrupting antioxidant systems. In vitro vivo experiments revealed that platform polarizes M1-type macrophages M2-type macrophages, altering microenvironment from proinflammatory prohealing. RNA sequencing accelerated reconstruction vascular network activating PI3K/AKT pathway VEGF secretion.This believed be beneficial not only but also other conditions involve regulation reactive species, such tumors

Язык: Английский

Процитировано

6