Shear Stress‐Triggered Thrombolysis by Yolk–Shell Nanoparticles with Piezoelectric‐Tribovoltaic Dynamic Schottky Junctions DOI
Huan Zheng, Pan Ran, Wenxiong Cao

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Abstract Triboelectric nanogenerators convert the mechanical energy of human body motions into sustained electric powers, but triboelectric effect is not yet integrated with pathological microenvironments. Herein, endogenous shear stress‐responsive platforms are designed for tribocatalytic thrombolysis through sequential deposition SiO 2 and Au layer onto tetragonal barium titanate (tBT) nanoparticles (NPs), followed by etching surface grafting arginine‐glycine‐aspartic acid (RGD) to obtain yolk–shell‐structured tBT@Au‐RGD NPs. High‐frequency frictions collisions between tBT yolks shells continuously stimulate electron–hole pairs reactive oxygen species (ROS) generations, dynamic Schottky junctions provide electron channels from inhibit recombinations. The piezopotential further promotes separations acts synergistically tribovoltaic ROS generation degrading fibrin networks thrombi. In a loop‐closed flow system demonstrates stress‐adaptable generations under embolization degrees 20% 80%. carotid thrombosis model RGD grafts increase NP accumulations four folds at thrombus site after 24 h intravenous administration, stenosis degree reduced 3.99% complete blood vessel recanalization negligible bleeding risk systemic toxicity. This study first attempt demonstrate stimuli‐induced piezoelectric effects disease treatment.

Язык: Английский

Engineering in NIR‐responsive photothermal materials and their application in wound healing administration DOI Creative Commons
A. Bassam, Meng-Xuan Du, Yuan Li

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.

Язык: Английский

Процитировано

5

Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications DOI Creative Commons

Tingting Meng,

Danfeng He,

Zhuolei Han

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 15, 2024

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have been engineered monitor macrophage metabolism, enabling evaluation of progression and replication intricate physiological signal patterns. They achieve this either directly or by delivering regulatory signals, thereby mapping phenotype effector functions through metabolic repurposing customize fate for therapy. However, a comprehensive summary regarding NM-mediated visualization coordinated rewiring maintain phenotypic equilibrium is currently lacking. This review aims address gap outlining recent advancements in NM-based immunotherapy. We initially explore relationship between polarization, disease, before delving into NM innovations that visualize activity elucidate onset fine-tune its remodeling macrophage-centered Finally, we discuss prospects challenges immunotherapy, aiming accelerate clinical translation. anticipate will serve as valuable reference researchers seeking leverage novel intervention-matched immunomodulators macrophages other fields engineering.

Язык: Английский

Процитировано

13

Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing DOI
Muhammad Umar Aslam Khan,

Muhammad Azhar Aslam,

Tooba Yasin

и другие.

Biomedical Materials, Год журнала: 2024, Номер 19(5), С. 052001 - 052001

Опубликована: Июль 8, 2024

Abstract Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular molecular levels. Quick wound problems associated with traditional techniques are being overcome multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, now considered promising class well-suited porous materials for in addition other applications. This detailed literature review provides an overview latest developments MOFs We have discussed synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, The possible major challenges limitations been discussed, along conclusions future perspectives. addresses MOFs-based several angles covers most current subject. readers may discover how advanced discipline by producing more inventive, useful, successful dressings. It influences development generations biomaterials wounds.

Язык: Английский

Процитировано

11

Intelligent Carbon Dots with Switchable Photo‐Activated Oxidase‐Mimicking Activity and pH Responsive Antioxidant Activity Adaptive to the Wound Microenvironment for Selective Antibacterial Therapy DOI Creative Commons
He Li, Zhi Li,

Meiqi Gu

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Abstract Intelligent antibacterial agent with controllable activities adaptive to the wound microenvironment is appealing reduce drug resistance and enhance efficiency. In this study, celery chosen as carbon source construct celery‐based dots (CECDs) double activities, i.e., reactive oxygen species (ROS)‐production ROS‐clearance activities. The ROS‐production capability of CECDs dependent on oxidase (OXD)‐mimicking activity, which only photo‐activated thus artificially controlled by light avoid production excess ROS. Meanwhile, optimal OXD‐mimicking activity occurrs at pH 5, close microenvironmental bacterial infection site, will efficacy. On other hand, exhibit antioxidant neutral or weak alkaline pH, assist healing wound. Thus, conversion ability can be dynamically intelligently switched automatically different stages treatment (from acid neutral/weak basic). proposed exert adorable selective against Gram‐positive bacteria satisfactory therapeutic effect infected mice. This study paves a new avenue design intelligent nanoagent sensitive condition, reducing assisting precise medicine.

Язык: Английский

Процитировано

10

Advancements in nanozymes research for the management of chronic wounds DOI

Duoduo Chen,

Guoxin Tan,

Shujian Tian

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157299 - 157299

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

10

Sprayable Hydrogel for pH-Responsive Nanozyme-Derived Bacteria-Infected Wound Healing DOI

Furong Chao,

Chengliang Cao, Yin Xu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative antimicrobial materials due their low cost, easy synthesis, good stability. Herein, we develop novel sprayable hydrogel based on carboxymethyl chitosan (CMCS) oxidized hyaluronic acid (OHA), incorporating Au nanoparticle-carbon nitride (AuNPs-C3N4) nanozyme, glucose, Mn2+ for bacteria-infected healing. forms rapidly in situ upon spraying gradually degrades the area, releasing AuNPs-C3N4 which exhibits robust glucose oxidase-like (GOx-like) activity, initiating comprehensive catalytic cascade through Mn2+-mediated Fenton-like reaction that generates hydroxyl radicals (•OH) eliminate Staphylococcus aureus (S. aureus) Methicillin-resistant S. (MRSA). Computational results indicate interactions between AuNPs g-C3N4 maximize synergistic effects heterojunction, improving O2 adsorption facilitating electron-O2 optimize activity. Further experiments demonstrate can cover wounds situ, while CMCS promotes collagen production fibroblast proliferation, offering viable strategy

Язык: Английский

Процитировано

2

NIR light-driven nanomotor with cascade photodynamic therapy for MRSA biofilm eradication and diabetic wound healing DOI Creative Commons
Yuanyuan Deng,

Jia Zheng,

Jianghua Li

и другие.

Theranostics, Год журнала: 2025, Номер 15(8), С. 3474 - 3489

Опубликована: Фев. 24, 2025

Background: Diabetic wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) are challenging to heal due biofilm formation, which impairs conventional antibiotics limited penetration and severe side effects. Near-infrared (NIR)-driven nanomotors autonomous motion photothermal effects show promise for antibacterial therapy but often lack targeted specificity. Lysostaphin (Ly), an enzyme targeting bacterial cell walls, offers excellent potential against drug-resistant MRSA. Methods: A novel NIR-driven CSIL nanomotor has fabricated by co-loading indocyanine green (ICG) lysostaphin onto spinous yolk-shell structured C/SiO2@C nanoparticles. The motion, penetration, efficacy of evaluated in vitro, while their eradication wound healing performance assessed MRSA-infected diabetic mouse model using a cascade photodynamic (CPDT) strategy. Results: exhibit properties MRSA-targeting They can effectively eradicate MRSA biofilms both vitro vivo, suppress virulence biofilm-related genes, thus promoting shaping microenvironment dominated M2 macrophages. CPDT strategy is able avoid excessive ROS production thermal damage, enabling safe effective therapy. Conclusion: nanomotors, integrated photothermal, photodynamic, properties, represent novel, efficient approach wounds, offering significant advantages over antibiotics.

Язык: Английский

Процитировано

2

Recombinant human collagen hydrogels with different stem cell-derived exosomes encapsulation for wound treatment DOI Creative Commons

Xiaoman Zeng,

Jingjing Gan, Danqing Huang

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 24, 2025

Exosomes-loaded hydrogels have potential value in wound treatment. Current studies focus on improving hydrogels' biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Herein, we present a novel biocompatible recombinant human collagen (RHC) hydrogel loading with MSCs-derived promoting healing. We modify the RHC methacrylate anhydride (MA) at optimal concentration, generating (RHCMA) ideal physiochemical properties exosome delivery (MSC-exos@RHCMA). Exosomes derived from adipose-derived MSCs (ADSC-exos), bone marrow-derived (BMSC-exos) umbilical cord (ucMSC-exos) are harvested culture supernatants loaded into RHCMA, respectively. These three systems exhibit desired sustained release features, can significantly improve cell proliferation migration. In addition, these MSC-exos@RHCMAs show excellent performance treating wounds of rats. Notably, demonstrated that healing effect occurs best under treatment ucMSC-exos@RHCMA, following inflammatory resolution, angiogenesis, formation. results would supply important clinical application MSC-exos future.

Язык: Английский

Процитировано

2

Chitosan-based hydrogel incorporated with polydopamine and protoporphyrin for photothermal-oxidation sterilization of bacteria-infected wound therapy DOI
Xiao Wang, Xiaojing Zhang, Wenjing Zhao

и другие.

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 89 - 100

Опубликована: Сен. 13, 2024

Язык: Английский

Процитировано

8

Enhanced antioxidant activity of CeO2/Ti3C2Tx nanocomposites for cardiovascular protection DOI
Yanjie Hou,

Jialing Liu,

Guannan Zhang

и другие.

Inorganic Chemistry Communications, Год журнала: 2025, Номер 174, С. 114006 - 114006

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

1