International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

International Forum of Allergy & Rhinology, Год журнала: 2023, Номер 13(4), С. 293 - 859

Опубликована: Март 6, 2023

In the 5 years that have passed since publication of 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic 2018), literature has expanded substantially. The ICAR-Allergic 2023 update presents 144 individual topics allergic rhinitis (AR), by over 40 from document. Originally presented also been reviewed updated. executive summary highlights key evidence-based findings recommendation full

Язык: Английский

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Advances and highlights in biomarkers of allergic diseases

Allergy, Год журнала: 2021, Номер 76(12), С. 3659 - 3686

Опубликована: Сен. 14, 2021

During the past years, there has been a global outbreak of allergic diseases, presenting considerable medical and socioeconomical burden. A large fraction diseases is characterized by type 2 immune response involving Th2 cells, innate lymphoid eosinophils, mast M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on disease endotypes, clusters, diagnoses, identification therapeutic targets, monitoring treatment efficacies. The availability powerful omics technologies, together with integrated data analysis network-based approaches can help clinically useful biomarkers. These biomarkers need to be accurately quantified using robust reproducible methods, such reliable point-of-care systems. Ideally, samples should collected quick, cost-efficient noninvasive methods. In recent plethora research directed toward finding novel diseases. Promising include sputum serum periostin exhaled nitric oxide. Several other biomarkers, pro-inflammatory mediators, miRNAs, eicosanoid molecules, epithelial barrier integrity, microbiota changes diagnosis in serum, body fluids air. Herein, we review studies asthma, chronic urticaria, atopic dermatitis, rhinitis, rhinosinusitis, food allergies, anaphylaxis, drug hypersensitivity allergen immunotherapy. addition, discuss COVID-19 within perspective recommendations management asthmatic patients during pandemic.

Язык: Английский

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Pathogenesis of allergic diseases and implications for therapeutic interventions

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 24, 2023

Abstract Allergic diseases such as allergic rhinitis (AR), asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic caused by an impaired immune system. Accompanied high recurrence rates, the steadily rising incidence rates of these attracting increasing attention. The pathogenesis is complex involves many factors, including maternal-fetal environment, living genetics, epigenetics, body’s status. exhibits a marked heterogeneity, with phenotype endotype defining visible features associated molecular mechanisms, respectively. With rapid development immunology, biology, biotechnology, new biological drugs have been designed for treatment diseases, anti-immunoglobulin E (IgE), anti-interleukin (IL)-5, anti-thymic stromal lymphopoietin (TSLP)/IL-4, to control symptoms. For doctors scientists, it becoming more important understand influencing pathogenesis, progress diseases. This review aimed assess epidemiology, therapeutic interventions AR, AAS, AD, FA. We hope help scientists systematically.

Язык: Английский

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Worldwide prevalence of rhinitis in adults: A review of definitions and temporal evolution

Clinical and Translational Allergy, Год журнала: 2022, Номер 12(3)

Опубликована: Март 1, 2022

Язык: Английский

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Update on pathomechanisms and treatments in allergic rhinitis

Allergy, Год журнала: 2022, Номер 77(11), С. 3309 - 3319

Опубликована: Июль 27, 2022

Abstract Allergic rhinitis (AR) is a global health problem with increasing prevalence and association an enormous medical socioeconomic burden. New recognition of immune cells such as type 2 innate lymphocytes (ILC2s), T helper (Th2) cells, follicular regulatory B dendritic epithelial in AR pathogenesis has been updated this review paper. An in‐depth understanding the mechanisms underlying will aid identification biomarkers associated disease ultimately provide valuable parameters critical to guide personalized targeted therapy. As only etiological treatment option for AR, allergen‐specific immunotherapy (AIT) attracted attention, evidence effectiveness AIT recently demonstrated several randomized controlled trials long‐term real‐life studies. The exploration biologics therapeutic options involved anti‐IgE anti‐type inflammatory agents; however, cost‐effectiveness these agents remains be elucidated precisely. In midst currently on‐going COVID‐19 pandemic, life‐threatening disease, although some studies have indicated that not risk factor severity mortality COVID‐19, needs confirmed multi‐centre, patients from different parts world.

Язык: Английский

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Macrophage polarization: an important role in inflammatory diseases

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 10, 2024

Macrophages are crucial cells in the human body's innate immunity and engaged a variety of non-inflammatory reactions. can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages anti-inflammatory M2-type macrophages. During inflammation, activated alternatively, maintaining reasonably steady ratio is critical for homeostasis

Язык: Английский

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Epidemiology of Allergic Rhinitis in Children: A Systematic Review and Meta-Analysis

The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2023, Номер 11(8), С. 2547 - 2556

Опубликована: Май 24, 2023

Язык: Английский

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S2k-Leitlinie zur fachärztlichen Diagnostik und Therapie von Asthma 2023

Pneumologie, Год журнала: 2023, Номер 77(08), С. 461 - 543

Опубликована: Июль 5, 2023

Zusammenfassung Das Management von Asthma hat sich in den letzten Jahrzehnten fundamental gewandelt. Die vorliegende Leitlinie zur Diagnostik und Therapie wurde für pneumologisch tätige Fachärztinnen Fachärzte entwickelt, welche detaillierte evidenzbasierte Informationen zu neuen diagnostischen therapeutischen Optionen benötigen. zeigt die neue Bedeutung der Biomarker, insbesondere Bluteosinophilen des exhalierten NO (FeNO), Algorithmen Asthma. Als erste Asthma-Leitlinie weltweit benennt nachhaltige Symptomprävention Asthma-Remission als Asthma-Therapieziele, durch Einsatz individuell angepasster, krankheitsmodifizierender Medikamente (wie inhalative Steroide, Allergenimmuntherapie oder Biologika) erreicht werden können. zentrale Behandlung typischen Asthma-Komorbiditäten wird zudem betont. Schließlich auch auf besondere Herausforderungen im Asthma-Management eingegangen, wie bspw. Schwangerschaft, schwerem arbeitsbedingten Asthma-Formen.

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The Relationship between Fine Particle Matter (PM2.5) Exposure and Upper Respiratory Tract Diseases

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(1), С. 98 - 98

Опубликована: Янв. 16, 2024

PM2.5 is one of the most harmful components airborne pollution and includes particles with diameters less than 2.5 μm. Almost 90% world's population lives in areas poor air quality exceeding norms established by WHO. exposure affects various organs systems human body including upper respiratory tract which prone to its adverse effects. can disrupt nasal epithelial cell metabolism, decrease integrity barrier, affect mucociliary clearance, alter inflammatory process mucosa. Those effects may increase chance developing diseases high pollution. PM2.5's contribution allergic rhinitis (AR) rhinosinusitis was recently thoroughly investigated. Numerous studies demonstrated mechanisms that occur when subjects AR or are exposed PM2.5. Various immunological changes alterations sinonasal epithelia were reported. These contribute observations higher concentrations symptoms patients number clinical visits. Thus, studying novel strategies against has become focus researchers' attention. In this review, we summarize current knowledge on healthy mucosa rhinosinusitis. Finally, advances particles' tract.

Язык: Английский

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Differentiation of COVID‐19 signs and symptoms from allergic rhinitis and common cold: An ARIA‐EAACI‐GA²LEN consensus

Allergy, Год журнала: 2021, Номер 76(8), С. 2354 - 2366

Опубликована: Март 17, 2021

Although there are many asymptomatic patients, one of the problems COVID-19 is early recognition disease. symptoms polymorphic and may include upper respiratory symptoms. However, be mistaken with common cold or allergic rhinitis. An ARIA-EAACI study group attempted to differentiate between three diseases.A modified Delphi process was used. The ARIA members who were seeing patients asked fill in a questionnaire on airway COVID-19, rhinitis.Among 192 invited respond questionnaire, 89 responded 87 questionnaires analysed. consensus then reported. A two-way ANOVA revealed significant differences symptom intensity diseases (p < .001).This approach enabled differentiation electronic algorithm will devised using questionnaire.

Язык: Английский

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