Advances and highlights in biomarkers of allergic diseases

Allergy, Год журнала: 2021, Номер 76(12), С. 3659 - 3686

Опубликована: Сен. 14, 2021

During the past years, there has been a global outbreak of allergic diseases, presenting considerable medical and socioeconomical burden. A large fraction diseases is characterized by type 2 immune response involving Th2 cells, innate lymphoid eosinophils, mast M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on disease endotypes, clusters, diagnoses, identification therapeutic targets, monitoring treatment efficacies. The availability powerful omics technologies, together with integrated data analysis network-based approaches can help clinically useful biomarkers. These biomarkers need to be accurately quantified using robust reproducible methods, such reliable point-of-care systems. Ideally, samples should collected quick, cost-efficient noninvasive methods. In recent plethora research directed toward finding novel diseases. Promising include sputum serum periostin exhaled nitric oxide. Several other biomarkers, pro-inflammatory mediators, miRNAs, eicosanoid molecules, epithelial barrier integrity, microbiota changes diagnosis in serum, body fluids air. Herein, we review studies asthma, chronic urticaria, atopic dermatitis, rhinitis, rhinosinusitis, food allergies, anaphylaxis, drug hypersensitivity allergen immunotherapy. addition, discuss COVID-19 within perspective recommendations management asthmatic patients during pandemic.

Язык: Английский

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Current Understanding of Asthma Pathogenesis and Biomarkers

Cells, Год журнала: 2022, Номер 11(17), С. 2764 - 2764

Опубликована: Сен. 5, 2022

Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations) and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have been made to dissect cellular molecular mechanisms of asthma. Aberrant T helper type 2 (Th2) inflammation most important pathological process for asthma, which mediated by Th2 cytokines, such as interleukin (IL)-5, IL-4, IL-13. Approximately 50% mild-to-moderate asthma large portion severe induced Th2-dependent inflammation. Th2-low can be non-Th2 including IL-17 tumor necrosis factor-α. There emerging evidence demonstrate that inflammation-independent processes also contribute pathogenesis. Protein kinases, adapter protein, microRNAs, ORMDL3, gasdermin B are newly identified molecules drive progression, independent Eosinophils, IgE, fractional exhaled nitric oxide, periostin practical biomarkers Th2-high Sputum neutrophils easily used diagnose Despite progress, more studies needed delineate complex identify new better diagnosis, classification, treatment.

Язык: Английский

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Photo-responsive polydopamine nanoenzyme microneedles with oxidative stress regulation ability for atopic dermatitis treatment

Nano Today, Год журнала: 2024, Номер 56, С. 102241 - 102241

Опубликована: Март 28, 2024

Язык: Английский

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EAACI guidelines on environmental science in allergic diseases and asthma – Leveraging artificial intelligence and machine learning to develop a causality model in exposomics

Allergy, Год журнала: 2023, Номер 78(7), С. 1742 - 1757

Опубликована: Фев. 6, 2023

Allergic diseases and asthma are intrinsically linked to the environment we live in patterns of exposure. The integrated approach understanding effects exposures on immune system includes ongoing collection large-scale complex data. This requires sophisticated methods take full advantage what this data can offer. Here discuss progress further promise applying artificial intelligence machine-learning approaches help unlock power environmental sets toward providing causality models exposure intervention. We a range relevant paradigms including way such trained validated together with examples machine learning applied allergic disease context specific as well attempts tie these streams representative exposome. also personalized medicine methodological healthcare final AI improve public health.

Язык: Английский

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Hot topics in allergen immunotherapy, 2023: Current status and future perspective

Allergy, Год журнала: 2023, Номер 79(4), С. 823 - 842

Опубликована: Ноя. 20, 2023

The importance of allergen immunotherapy (AIT) is multifaceted, encompassing both clinical and quality-of-life improvements cost-effectiveness in the long term. Key mechanisms tolerance induced by AIT include changes memory type allergen-specific T- B-cell responses towards a regulatory phenotype with decreased Type 2 responses, suppression IgE increased IgG

Язык: Английский

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Roles of lncRNAs in NF-κB-Mediated Macrophage Inflammation and Their Implications in the Pathogenesis of Human Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2670 - 2670

Опубликована: Фев. 25, 2024

Over the past century, molecular biology’s focus has transitioned from proteins to DNA, and now RNA. Once considered merely a genetic information carrier, RNA is recognized as both vital element in early cellular life regulator complex organisms. Long noncoding RNAs (lncRNAs), which are over 200 bases long but do not code for proteins, play roles gene expression regulation signal transduction by inducing epigenetic changes or interacting with various RNAs. These interactions exhibit range of functions cell types, including macrophages. Notably, some macrophage lncRNAs influence activation NF-κB, crucial transcription factor governing immune inflammatory responses. Macrophage NF-κB instrumental progression pathological conditions sepsis, atherosclerosis, cancer, autoimmune disorders, hypersensitivity. It orchestrates related responses, inflammation, survival, proliferation. Consequently, its malfunction key contributor onset development these diseases. This review aims summarize function regulating activity particular emphasis on their relevance human diseases potential therapeutic targets. The insights gained studies lncRNAs, discussed this review, could provide valuable knowledge treatments involving

Язык: Английский

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Epithelial barrier theory in the context of nutrition and environmental exposure in athletes

Allergy, Год журнала: 2024, Номер 79(11), С. 2912 - 2923

Опубликована: Июль 16, 2024

Exposure to toxic substances, introduced into our daily lives during industrialization and modernization, can disrupt the epithelial barriers in skin, respiratory, gastrointestinal systems, leading microbial dysbiosis inflammation. Athletes physically active individuals are at increased risk of exposure agents that damage microbiome, their extreme physical exercise exerts stress on many organs, resulting tissue Epithelial barrier-damaging substances include surfactants enzymes cleaning products, laundry dishwasher detergents, chlorine swimming pools, microplastics, air pollutants such as ozone, particulate matter, diesel exhaust. Athletes' high-calorie diet often relies processed foods may contain food emulsifiers other additives cause barrier dysfunction dysbiosis. The type material used sport equipment clothing extensive increase inflammatory effects. Excessive travel-related stress, sleep disturbances different microbe represent additional factors. Here, we review detrimental impact microbiome; bring a new perspective factors affecting health performance athletes individuals.

Язык: Английский

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Interplay between extracellular vesicles and allergic diseases: Current insights and future perspectives

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract The field of extracellular vesicle (EV) research has rapidly evolved, revealing their significant roles in various biological processes and clinical applications. Allergic diseases are prevalent immunological disorders characterized by exaggerated hypersensitivity reactions to allergens, leading diverse manifestations that can severely impact quality life. Recently, studies have underscored the pivotal role EVs allergic conditions, including asthma, rhinitis, atopic dermatitis. In this review, we provide a comprehensive overview recent advances separation characterization EVs, diseases, diagnostic value as biomarkers. Additionally, explore therapeutic potential for treatment prevention conditions. Overall, emerging insights into present promising opportunities enhancing diagnosis, treatment, management diseases.

Язык: Английский

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Utility of artificial intelligence in dermatology: Challenges and perspectives

IP Indian Journal of Clinical and Experimental Dermatology, Год журнала: 2025, Номер 11(1), С. 1 - 9

Опубликована: Фев. 8, 2025

Medicine is entering a transformative era with disruptive technologies such as virtual reality, genomic prediction, data analytics, personalized medicine, stem cell therapy, 3-D printing, and nanorobotics. Dermatology significantly impacted by these advancements, particularly through artificial intelligence (AI). AI, defined devices performing functions typically requiring human intelligence, plays an increasingly prominent role in healthcare. John McCarthy coined the term AI 1956. In dermatology, aids diagnosis, treatment planning, understanding diseases across communities. Machine learning deep learning, subsets of require extensive datasets robust analysis to improve accuracy performance. AI's integration into dermatology revolutionizing field enabling precision, reducing errors, minimizing staffing needs. tools support dermatologists diagnosing treating various conditions, from psoriasis acne dermatitis ulcers. Convolutional neural networks (CNNs) enhance classification skin lesions, while predictive models optimize strategies based on patient data. extends oncology, where it improves cancer detection image histopathological assessment. Despite its potential, faces challenges quality, representativeness, algorithm transparency, ethical considerations. Addressing biases, standardizing imaging protocols, enhancing human-machine collaboration are crucial for maximizing benefits. holds immense promise offering innovative solutions care diagnostic accuracy. The future includes advancements vision-language models, federated precision medicine approaches. Overcoming related privacy, regulatory standards, model evaluation essential successful clinical practice. Collaborative efforts among stakeholders vital drive progress realize full potential ultimately improving outcomes globally.

Язык: Английский

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Role of the microbiome in regulation of the immune system

Allergology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.

Язык: Английский

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