Genes,
Год журнала:
2025,
Номер
16(2), С. 194 - 194
Опубликована: Фев. 4, 2025
Kimura’s
disease
(KD)
is
a
rare,
chronic
inflammatory
disorder
that
predominantly
affects
young
men
of
East
Asian
descent.
It
characterized
by
painless
solid
masses
primarily
localized
to
the
deep
subcutaneous
tissues
head
and
neck,
eosinophilia,
elevated
serum
immunoglobulin
E
(IgE).
While
exact
cause
remains
unclear,
pathogenesis
thought
involve
dysregulated
immune
responses,
particularly
those
mediated
T-helper
cells
2
(Th2),
eosinophils,
IgE
production.
Advances
in
molecular
biology
have
suggested
genetic
factors
play
significant
role
development
progression
this
condition.
Recent
studies
implicated
several
genes
pathways
its
development,
understanding
these
components
may
provide
insights
into
better
diagnostic
tools
therapeutic
strategies
for
KD.
In
regard,
biological
therapies,
targeting
mechanisms
underlying
KD,
been
used
treat
challenging
condition
with
promising
results,
contributing
rare
disorder.
The
aim
study
was
review
literature
concerning
contribute
special
focus
on
therapies.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Фев. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 1, 2024
The
epithelial
barrier
serves
as
a
critical
defense
mechanism
separating
the
human
body
from
external
environment,
fulfilling
both
physical
and
immune
functions.
This
plays
pivotal
role
in
shielding
environmental
risk
factors
such
allergens,
pathogens,
pollutants.
However,
since
19th
century,
escalating
threats
posed
by
pollution,
global
warming,
heightened
usage
of
industrial
chemical
products,
alterations
biodiversity
have
contributed
to
noteworthy
surge
allergic
disease
incidences.
Notably,
diseases
frequently
exhibit
dysfunction
barrier.
proposed
hypothesis
introduces
novel
avenue
for
prevention
treatment
diseases.
Despite
increased
attention
development,
numerous
questions
persist
regarding
mechanisms
underlying
disruption
normal
function.
Consequently,
this
review
aims
provide
comprehensive
overview
barrier’s
diseases,
encompassing
influencing
factors,
assessment
techniques,
repair
methodologies.
By
doing
so,
it
seeks
present
innovative
strategies
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Food
allergens
are
the
key
triggers
of
allergic
diarrhea,
causing
damage
to
immune-rich
ileum.
This
weakens
mucosal
barrier
and
tight
junctions,
increases
intestinal
permeability,
exacerbates
allergen
exposure,
thereby
worsening
condition.
Sesamin,
a
natural
lignan
isolated
from
sesame
seed,
has
shown
potential
in
regulating
immune
responses,
but
its
effects
on
health
remain
unclear.
In
this
study,
we
constructed
an
ovalbumin
(OVA)-induced
diarrhea
mouse
model,
which
demonstrated
increased
mast
cell
degranulation,
reduced
junction
integrity,
impaired
function.
Pro-inflammatory
cytokines
were
significantly
ileum,
along
with
unbalanced
cluster
differentiation
4
(CD4
Allergy and Asthma Proceedings,
Год журнала:
2025,
Номер
46(2), С. e61 - e69
Опубликована: Фев. 27, 2025
Background:
The
hypertension
risk
in
the
co-occurrence
of
allergic
diseases
remains
largely
unknown.
Objective:
We
aimed
to
investigate
association
between
pattern
and
morbidity
mortality,
evaluate
additive
interaction
effects
diseases.
Methods:
A
nationally
representative
population
from
U.S.
National
Health
Interview
Survey
2012
was
enrolled.
Hypertension
five
specific
diseases,
including
asthma,
rhinitis
(AR),
food
allergy
(FA),
eczema,
other
(OA),
were
determined.
mortality
identified
until
December
31,
2019.
evaluated
two
on
risk:
relative
excess
due
(RERI)
attributable
proportion
joint
effect
(AP)
(shown
as
percentages)
calculated.
For
modifiable
lifestyle
factors
with
significant
heterogeneity
subgroups,
we
examined
modification.
Results:
Totally,
34,392
participants
Four
patterns
associated
an
increased
hypertension,
AR
+
FA
(odds
ratio
[OR]
2.25
[95%
confidence
interval
{CI},
1.52‐3.35]),
eczema
OA
(OR
1.94
CI,
1.14‐3.30]),
1.76
1.18‐2.64]),
asthma
1.67
1.33‐2.08]).
Five
three
hypertension.
Additive
interactions
seen
(RERI,
0.65;
AP,
29%),
0.43;
22%),
0.21;
12%),
0.05;
3%).
only
among
a
body
mass
index
(BMI)
≥
30
kg/m
2
(p
=
0.021).
With
median
follow-up
7.5
years,
one
showed
(hazard
4.32,
95%
CI:
1.52‐12.23),
observed
2.33;
52%).
Conclusion:
several
significantly
mortality.
Potential
biologic
modification
BMI
found.
Precision
primary
prevention
is
necessary
for
patients
co-occurring
Marine Drugs,
Год журнала:
2024,
Номер
22(5), С. 226 - 226
Опубликована: Май 17, 2024
Utilizing
plant-based
resources,
particularly
their
by-products,
aligns
with
sustainability
principles
and
circular
bioeconomy,
contributing
to
environmental
preservation.
The
therapeutic
potential
of
plant
extracts
is
garnering
increasing
interest,
this
study
aimed
demonstrate
promising
outcomes
from
an
extract
obtained
underutilized
waste.
Chaetomorpha
linum,
invasive
macroalga
found
in
the
Orbetello
Lagoon,
thrives
eutrophic
conditions,
forming
persistent
mats
covering
approximately
400
hectares
since
2005.
biomass
C.
linum
undergoes
mechanical
harvesting
treated
as
waste,
requiring
significant
human
efforts
economic
resources—A
critical
concern
for
municipalities.
Despite
posing
challenges
local
ecosystems,
identified
a
natural
source
bioactive
metabolites.
Phytochemical
characterization
revealed
lipids,
amino
acids,
other
compounds
anti-inflammatory
activity
extract.
In
vitro
assays
LPS-stimulated
RAW
264.7
TNF-α/IFN-γ-stimulated
HaCaT
cells
showed
inhibited
reactive
oxygen
species
(ROS),
nitric
oxide
(NO),
prostaglandin
E2
(PGE2)
productions,
reduced
inducible
synthase
(iNOS)
cyclooxygenase-2
(COX-2)
expressions
via
NF-κB
nuclear
translocation,
cells.
It
also
chemokines
(TARC/CCL17,
RANTES/CCL5,
MCP-1/CCL2,
IL-8)
cytokine
IL-1β
production
cells,
suggesting
candidate
chronic
diseases
like
atopic
dermatitis.
Finally,
silico
studies
indicated
palmitic
acid
contributor
observed
effect.
This
research
not
only
uncovered
untapped
but
laid
foundation
its
integration
into
promoting
sustainable
practices,
innovative
applications
across
various
industries.
Abstract
Background
The
role
of
lung
group
2
innate
lymphoid
cell
(ILC2)
activation
in
allergic
asthma
is
increasingly
established.
However,
the
regulatory
mechanisms
underlying
hypoxia‐inducible
factor‐1α
(HIF‐1α)‐mediated
glycolysis
ILC2‐mediated
airway
inflammation
remain
unclear.
Objective
To
investigate
HIF‐1α/glycolysis
axis
inflammation.
Methods
Glycolysis
and
HIF‐1α
inhibitors
were
used
to
identify
their
effect
on
function
glucose
metabolism
mouse
human
ILC2s
vivo
vitro.
Blocking
mice
under
interleukin‐33
(IL‐33)
stimulation
performed
test
ILC2
responses.
Conditional
HIF‐1α‐deficient
confirm
specific
ILC2‐driven
models.
Transcriptomic,
metabolic,
chromatin
immunoprecipitation
analyses
elucidate
mechanism.
Results
involved
crucial
Single‐cell
sequencing
data
analysis
qPCR
confirmation
revealed
a
significant
upregulation
glycolysis‐related
genes,
particularly
HIF‐1α,
murine
after
IL‐33
intranasal
administration
or
injection.
Treatment
with
inhibitor
2‐deoxy‐D‐glucose
(2‐DG)
2‐methoxyestradiol
(2‐ME)
abrogated
by
suppressing
function.
showed
reduced
response
induced
upon
house
dust
mite
(HDM)
stimulation.
Transcriptome
metabolic
significantly
impaired
conditional
knockout
compared
that
littermate
controls.
Chromatin
results
confirmed
transcriptional
downregulation
genes
HIF‐1α‐knockout
2‐DG‐treated
mice.
Furthermore,
correlated
downregulated
patients
asthma.
Conclusion
critical
for
controlling
responses
has
potential
immunotherapeutic
value
Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1331 - 1331
Опубликована: Окт. 31, 2024
Within
the
pediatric
population,
bronchial
asthma
is
one
of
most
prevalent
chronic
respiratory
system
diseases.
The
number
exacerbations,
severity,
and
duration
symptoms
all
have
a
significant
impact
on
children's
life
quality.
In
last
decades,
prevention
management
strategies
this
pathology
focused
maintaining
or
even
increasing
pulmonary
function
to
maximum
levels
in
early
childhood,
as
it
has
been
demonstrated
that
functional
deficits
at
level
occurring
before
school
age
cause
pathological
manifestations
later,
adulthood.
epithelium
airways
implicitly
lung
first
barrier
against
lesions
caused
by
pro-oxidative
factors.
Both
oxidative
antioxidative
factors
can
be
endogenous
origin
(produced
body)
exogenous
(from
environment
diet).
Good
functioning
antioxidant
defense
mechanisms
from
molecular
tissue
level,
balance
between
anti-
factors,
influence
occurrence
compensatory
epithelium,
causing
delay
local
responses
stress
induced
inflammation
(bronchial
remodeling,
thickening
airway
smooth
muscles,
bronchoconstriction,
hyper-reactivity).
These
underlie
pathophysiological
changes
asthma.
Numerous
studies
carried
out
among
population
inclusively
effectiveness
antioxidants
prophylaxis,
slowing
down
preventing
progression
pathology.
This
review
complements
scientific
articles,
aiming
emphasizing
complexity
physio-pathological
pathways
their
importance
occurrence,
development,
therapeutic
response
asthma,
providing
good
understanding
relationship
being
source
future
strategies.
As
a
highly
dynamic
tissue,
bone
is
continuously
rebuilt
throughout
life.
Both
formation
by
osteoblasts
and
resorption
osteoclasts
constitute
reconstruction
homeostasis.
The
equilibrium
of
homeostasis
governed
many
complicated
signaling
pathways
that
weave
together
to
form
an
intricate
network.
These
coordinate
the
meticulous
processes
resorption,
ensuring
structural
integrity
vitality
skeletal
system.
Dysregulation
homeostatic
regulatory
network
contributes
development
progression
diseases.
Significantly,
imbalanced
further
disrupts
triggers
cascade
reaction
exacerbates
disease
engenders
deleterious
cycle.
Here,
we
summarize
influence
on
homeostasis,
elucidating
interplay
crosstalk
among
them.
Additionally,
review
mechanisms
underpinning
imbalances
across
diverse
landscapes,
highlighting
current
prospective
therapeutic
targets
clinical
drugs.
We
hope
this
will
contribute
holistic
understanding
molecular
sustaining
which
are
promising
research
shed
light
targeted
