The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis

Obesity Reviews, Год журнала: 2012, Номер 14(2), С. 95 - 109

Опубликована: Окт. 31, 2012

Summary While many women with polycystic ovary syndrome ( PCOS ) are overweight, obese or centrally obese, the effect of excess weight on outcomes is inconsistent. The review aimed to assess effects obesity and central reproductive, metabolic psychological features . MEDLINE , EMBASE CINAHL C ochrane entral R egister ontrolled T rials CENTRAL PSYCINFO were searched for studies reporting according body mass index categories fat distribution. Data presented as mean difference risk ratio (95% confidence interval). This included 30 eligible studies. Overweight had decreased sex hormone‐binding globulin SHBG ), increased total testosterone, free androgen index, hirsutism, fasting glucose, insulin, homeostatic model assessment‐insulin resistance worsened lipid profile. Obesity significantly all reproductive measured except hirsutism when compared normal no differences in total‐cholesterol low‐density lipoprotein‐cholesterol testosterone women. Central was associated higher insulin levels. These results suggest that prevention treatment important management

Язык: Английский

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Recommendations for epidemiologic and phenotypic research in polycystic ovary syndrome: an androgen excess and PCOS society resource

Human Reproduction, Год журнала: 2019, Номер 34(11), С. 2254 - 2265

Опубликована: Авг. 5, 2019

What are the best practices for undertaking epidemiologic and phenotypic studies in polycystic ovary syndrome (PCOS)?Best of PCOS outlined.Currently methodologies used epidemiology phenotypes vary widely, comparability is low, reducing ability to harmonize studies.The Androgen Excess (AE-PCOS) Society established a Task Force draft research resource PCOS, with aim providing guidelines on study design execution, insights into limitations alternatives protocols be used, taking consideration global perspective.A targeted review literature was carried out as necessary.High level recommendations include following: (i) Before initiating study, number critical factors should addressed including selecting population diagnostic criteria (which ideally align International Guidelines), type observational undertaken primary secondary endpoint(s) study.(ii) To assess 'natural' or true phenotype least medically biased, broadest most generalizable population, definition used.(iii) Four (Phenotypes A through D), based presence absence three general features (oligo-anovulation, hyperandrogenism ovarian morphology), ascertained.(iv) In studies, detection rests accuracy sensitivity methods assessing individual disorder, how 'normal' defined.(v) Although an assessment algorithm that minimizes use certain measures (e.g. androgen levels and/or ultrasonography) can devised, when possible it preferable uniformly all subjects parameters interest.(vi) The inclusion who do not appear have (i.e. 'non-PCOS') will provide necessary cohort establish population-specific normative ranges various PCOS. (vii) Epidemiologic unselected populations yield relatively limited numbers available genetic study; alternatively, large population-based potentially generate unaffected individuals may serve controls. (viii) benefit from clear governance structure begin by informing, educating engaging both formal informal leaders study. (ix) designing their investigators should, advance, statistical power recognize, manage account inherent biases. (x) Subjects suspected having but not/cannot complete evaluation 'possible PCOS') included imputation, assigning them 'diagnostic weight' those similar clinical completed (xi) obtaining, storing retrieving subject data, assessed consecutively using uniform data collection form; depth possible. (xii) Maintenance paper electronic medical records focus ensuring quality, institutional ethical compliance, familiarity country-dependent laws, biobanking-specific tissue laws laws. (xiii) obtaining biobanking samples, these collected at time first assessment. (xiv) Access stored sets granted other bona fide researchers conducting public interest. (xv) SOPs detailing exact method each activities handling samples ensure performed uniformly. (xvi) must resourced adequately.As reports involving expert interpretation experiential published biases This risk minimized present experts varying fields aligning recent international evidence-based consensus approval board AE-PCOS.These encourage worldwide undertake much needed increasing validity, integrity data.The received no funding. R.A. serves consultant Medtronic, Spruce Biosciences Ansh Labs; has funding Ferring Pharmaceuticals; advisory Martin Imaging; R.L. MSD J.L. fees grant support Dutch Heart Association, Netherlands Organisation Health Research Development (ZonMw), Pharmaceuticals, Danone, Euroscreen/Ogeda Titus Care; H.T. receives National Medical Council; K.K., L.M.-P., S.S.M. B.O.Y. potential conflicts interest.N/A.

Язык: Английский

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Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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From Pathophysiology to Treatment: The Role of Ferroptosis in PCOS

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(2)

Опубликована: Фев. 17, 2025

Polycystic ovary syndrome (PCOS) is a prevalent gynecological endocrine and metabolic disorder in women, with an incidence rate of 10-13%. The etiology PCOS multifaceted, involving genetic predisposition, environmental influences, lifestyle factors, dysregulation. Iron, critical mineral, not only plays role regulating female physiological functions the progression but also requires careful management to avoid deficiency. However, excess iron can trigger ferroptosis, form nonapoptotic cell death characterized by accumulation lipid peroxides. While numerous studies have explored ferroptosis patients animal models, precise mechanisms therapeutic implications remain inadequately understood. This review seeks elucidate pathophysiology contributory factors ferroptosis. Additionally, we examine diverse manifestations evaluate its role. Furthermore, introduce ferroptosis-related traditional Chinese medicines that may enhance understanding pathogenesis aid development targeted therapies for PCOS.

Язык: Английский

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Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution

Human Reproduction Open, Год журнала: 2019, Номер 2020(1)

Опубликована: Дек. 5, 2019

What are the predictive factors for later development of type 2 diabetes (T2DM) in women with polycystic ovary syndrome (PCOS)?Obesity and abdominal fat distribution PCOS mid-fertile years were major risk T2DM 24 when lifestyle similar to controls.Women have an increased prevalence T2DM.A longitudinal cross-sectional study was performed. Women examined 1992 2016. Randomly selected, age-matched from general population served as (n = 27), attending outpatient clinical at a tertiary care centre infertility or hirsutism diagnosed (mean age 30 years) re-examined 2016 52 years). World Health Organization MONItoring trends determinants CArdiovascular disease (WHO MONICA-GOT) 2008, aged 38-68 years, controls 94), they previously 1995. At both baseline follow-up, had blood samples taken, underwent examination completed structured questionnaires, also glucose clamp test baseline.None baseline. 24-year 19% versus 1% (P < 0.01). All who developed obese waist-hip ratio (WHR) >0.85 No difference seen between regarding use high-fat diet, Mediterranean diet amount physical activity follow-up peri/postmenopausal age. However, lower usage high-sugar compared The mean increases BMI WHR per year during period.The small sample size fact that recruited due make generalization milder forms uncertain.Obesity distribution, but not hyperandrogenism se, peri/postmenopausal. Lifestyle time.The financed by grants Swedish state under agreement government country councils, ALF-agreement (ALFGBG-718611), Gothenburg Medical Association GLS 694291 780821, Heart Lung Foundation Hjalmar Svensson Foundation. authors no conflict interest.

Язык: Английский

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Androgens Modulate the Immune Profile in a Mouse Model of Polycystic Ovary Syndrome

Advanced Science, Год журнала: 2024, Номер 11(28)

Опубликована: Май 20, 2024

Polycystic ovary syndrome (PCOS) is associated with a low-grade inflammation, but it unknown how hyperandrogenism, the hallmark of PCOS, affects immune system. Using PCOS-like mouse model, demonstrated that hyperandrogenism cell populations in reproductive, metabolic, and immunological tissues differently site-specific manner. Co-treatment an androgen receptor antagonist prevents most these alterations, demonstrating effects are mediated through activation. Dihydrotestosterone (DHT)-exposed mice displayed drastically reduced eosinophil population uterus visceral adipose tissue (VAT). A higher frequency natural killer (NK) cells elevated levels IFN-γ TNF-α seen uteri androgen-exposed mice, while NK VAT spleen expression level CD69, marker activation or residency. Distinct alterations macrophages uterus, ovaries, also found DHT-exposed can potentially be linked to traits model. Indeed, insulin-resistant, albeit unaltered fat mass. Collectively, causes tissue-specific reproductive organs VAT, which have considerable implications on function contribute fertility metabolic comorbidities PCOS.

Язык: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(14), С. 4243 - 4243

Опубликована: Июль 20, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) are prevalent conditions that have been correlated with infertility through overlapped pathophysiological mechanisms. MASLD is associated metabolic considered among the major causes of chronic disease, while PCOS, which characterized by ovulatory dysfunction hyperandrogenism, one leading female infertility. The links between PCOS not yet fully elucidated, insulin resistance, hyperandrogenemia, obesity, dyslipidemia being key pathways contribute to lipid accumulation, inflammation, fibrosis, aggravating dysfunction. On other hand, exacerbates resistance dysregulation in women creating a vicious cycle progression. Understanding intricate relationship crucial improving clinical management, collaborative efforts different medical specialties essential optimize fertility health outcomes individuals PCOS. In this review, we summarize complex interplay highlighting importance increasing attention prevention, diagnosis, treatment both entities.

Язык: Английский

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The effect of anterior disc displacement with polycystic ovarian syndrome on adolescent condylar bone remodeling

BMC Oral Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 7, 2025

Adolescent females have a high prevalence of temporomandibular joint (TMJ) anterior disc displacement (ADD), which can lead to condylar resorption and dentofacial deformity. Polycystic ovarian syndrome (PCOS) is common endocrine disorder that disrupts bone metabolism. However, the effects PCOS on remodeling especially after repositioning (DR) surgery are not well understood. This was retrospective study. Patients aged 12 20 years diagnosed with ADD were reviewed matched into 3 groups: A (ADD without PCOS), B untreated C treated PCOS). Each group divided 2 subgroups according observation (A1, B1, C1) DR (A2, B2, C2). Condylar height (CH) measured by MRI at start (T0) more than 6 months follow-up (T1). ∆CH (T1-T0) compared within between groups. 93 patients (157 joints) an average age 15.17 ± 2.35 period 14.04 9.11 selected in Group B1 significantly larger Groups A1 C1 (p = 0.048, p 0.018). While it significant smaller A2 C2 < 0.001, 0.023). There no difference A2. acquired each A, B, 0.05). Multiple linear regression analysis showed related presence 0.003), treatment 0.001), 0.001). aggravate degeneration affect DR. improve remodeling.

Язык: Английский

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Fungal influence: The role of the gut mycobiome in women’s health

Cell Host & Microbe, Год журнала: 2025, Номер 33(1), С. 17 - 19

Опубликована: Янв. 1, 2025

Язык: Английский

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Associations of maternal per- and polyfluoroalkyl substance plasma concentrations during pregnancy with offspring polycystic ovary syndrome and related characteristics in Project Viva

Environmental Research, Год журнала: 2025, Номер unknown, С. 120786 - 120786

Опубликована: Янв. 1, 2025

Язык: Английский

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