International Journal of Molecular Sciences,
Год журнала:
2019,
Номер
20(5), С. 1223 - 1223
Опубликована: Март 11, 2019
Aging
and
various
age-related
diseases
are
associated
with
reductions
in
melatonin
secretion,
proinflammatory
changes
the
immune
system,
a
deteriorating
circadian
sirtuin-1
(SIRT1)
activity.
In
non-tumor
cells,
several
effects
of
abolished
by
inhibiting
SIRT1,
indicating
mediation
SIRT1.
Melatonin
is,
addition
to
its
antioxidant
roles,
an
stimulatory
agent.
However,
it
can
act
as
either
pro-
or
anti-inflammatory
regulator
context-dependent
way.
stimulate
release
cytokines
other
mediators,
but
also,
under
different
conditions,
suppress
inflammation-promoting
processes
such
NO
release,
activation
cyclooxygenase-2,
inflammasome
NLRP3,
gasdermin
D,
toll-like
receptor-4
mTOR
signaling,
cytokine
SASP
(senescence-associated
secretory
phenotype),
amyloid-β
toxicity.
It
also
activates
network,
which
SIRT1
activation,
upregulation
Nrf2
downregulation
NF-κB,
IL-4
IL-10
involved.
A
perhaps
crucial
action
may
be
promotion
macrophage
microglia
polarization
favor
phenotype
M2.
addition,
many
factors
networks
subject
regulation
microRNAs
that
target
mRNAs
respective
upregulate
them
targeting
their
inhibitor
proteins.
BioMed Research International,
Год журнала:
2019,
Номер
2019, С. 1 - 16
Опубликована: Апрель 7, 2019
Aging
is
related
to
a
number
of
functional
and
morphological
changes
leading
progressive
decline
the
biological
functions
an
organism.
Reactive
Oxygen
Species
(ROS),
released
by
several
endogenous
exogenous
processes,
may
cause
important
oxidative
damage
DNA,
proteins,
lipids,
cellular
dysfunctions.
The
imbalance
between
ROS
production
antioxidant
defenses
brings
stress
conditions
and,
accumulation
ROS,
aging-associated
diseases.
purpose
this
review
provide
overview
most
relevant
data
reported
in
literature
on
natural
compounds,
mainly
phytochemicals,
with
activity
their
potential
protective
effects
age-related
diseases
such
as
metabolic
syndrome,
diabetes,
cardiovascular
disease,
cancer,
neurodegenerative
chronic
inflammation,
possibly
lower
side
effects,
when
compared
other
drugs.
Science,
Год журнала:
2020,
Номер
368(6497), С. 1371 - 1376
Опубликована: Май 21, 2020
The
effect
of
immunometabolism
on
age-associated
diseases
remains
uncertain.
In
this
work,
we
show
that
T
cells
with
dysfunctional
mitochondria
owing
to
mitochondrial
transcription
factor
A
(TFAM)
deficiency
act
as
accelerators
senescence.
mice,
these
instigate
multiple
aging-related
features,
including
metabolic,
cognitive,
physical,
and
cardiovascular
alterations,
which
together
result
in
premature
death.
cell
metabolic
failure
induces
the
accumulation
circulating
cytokines,
resembles
chronic
inflammation
is
characteristic
aging
("inflammaging").
This
cytokine
storm
itself
acts
a
systemic
inducer
Blocking
tumor
necrosis
factor-α
signaling
or
preventing
senescence
nicotinamide
adenine
dinucleotide
precursors
partially
rescues
mice
Nature,
Год журнала:
2023,
Номер
620(7973), С. 374 - 380
Опубликована: Авг. 2, 2023
Low-grade
inflammation
is
a
hallmark
of
old
age
and
central
driver
ageing-associated
impairment
disease1.
Multiple
factors
can
contribute
to
inflammation2;
however,
the
molecular
pathways
that
transduce
aberrant
inflammatory
signalling
their
impact
in
natural
ageing
remain
unclear.
Here
we
show
cGAS-STING
pathway,
which
mediates
immune
sensing
DNA3,
critical
chronic
functional
decline
during
ageing.
Blockade
STING
suppresses
phenotypes
senescent
human
cells
tissues,
attenuates
ageing-related
multiple
peripheral
organs
brain
mice,
leads
an
improvement
tissue
function.
Focusing
on
brain,
reveal
activation
triggers
reactive
microglial
transcriptional
states,
neurodegeneration
cognitive
decline.
Cytosolic
DNA
released
from
perturbed
mitochondria
elicits
cGAS
activity
microglia,
defining
mechanism
by
engaged
brain.
Single-nucleus
RNA-sequencing
analysis
microglia
hippocampi
gain-of-function
mouse
model
demonstrates
engagement
sufficient
direct
states
leading
bystander
cell
inflammation,
neurotoxicity
impaired
memory
capacity.
Our
findings
establish
pathway
as
blockade
potential
strategy
halt
neurodegenerative
processes
age.
Science,
Год журнала:
2021,
Номер
374(6571), С. 1070 - 1075
Опубликована: Ноя. 25, 2021
Inflammation
is
an
integral
part
of
animal
biology.
It
provides
critical
protection
from
adverse
environmental
factors
by
enforcing
the
defense
homeostasis
and
functional
structural
integrity
tissues
organs.
Recent
advances
have
uncovered
a
broad
range
biological
processes
that
involve
inflammatory
control,
calling
for
renewed
framework
inflammation
beyond
its
classical
roles
in
infection
injury.
In
this
Review,
new
perspectives
on
biology
are
discussed
research
directions
suggested
to
address
fundamental
gaps
our
current
understanding.
Seminars in Immunology,
Год журнала:
2018,
Номер
40, С. 83 - 94
Опубликована: Ноя. 27, 2018
The
unprecedented
increase
of
life
expectancy
challenges
society
to
protect
the
elderly
from
morbidity
and
mortality
making
vaccination
a
crucial
mean
safeguard
this
population.
Indeed,
infectious
diseases,
such
as
influenza
pneumonia,
are
among
top
killers
people
in
world.
Elderly
individuals
more
prone
severe
infections
less
responsive
prevention,
due
immunosenescence
combined
with
progressive
proinflammatory
status
characteristic
aging
process
(inflammaging).
These
factors
responsible
for
most
age-related
diseases
correlate
poor
response
vaccination.
Therefore,
it
is
utmost
interest
deepen
knowledge
regarding
role
inflammaging
responsiveness
support
development
effective
strategies
designed
elderly.
In
review
we
analyse
impact
age-associated
inflammaging,
immunobiography
on
immune
elderly,
consider
systems
biology
approaches
integrating
multitude
data
order
rationally
design
specifically
tailored
