Ageing Research Reviews,
Год журнала:
2021,
Номер
70, С. 101410 - 101410
Опубликована: Июль 17, 2021
Human
aging
is
a
multifactorial
phenomenon
that
affects
numerous
organ
systems
and
cellular
processes,
with
the
immune
system
being
one
of
most
dysregulated.
Immunosenescence,
gradual
deterioration
system,
inflammaging,
chronic
inflammatory
state
persists
in
elderly,
are
among
plethora
changes
occur
during
aging.
Almost
all
populations
cells
change
age
terms
numbers
and/or
activity.
These
alterations
general
highly
detrimental,
resulting
an
increased
susceptibility
to
infections,
reduced
healing
abilities,
altered
homeostasis
promote
emergence
age-associated
diseases
such
as
cancer,
diabetes,
other
associated
inflammation.
Thanks
recent
developments,
several
strategies
have
been
proposed
target
central
immunological
processes
or
specific
subpopulations
affected
by
therapeutic
approaches
could
soon
be
applied
clinic
slow
down
even
reverse
age-induced
order
rejuvenate
prevent
reduce
impact
various
diseases.
Due
its
systemic
nature
interconnection
body,
attractive
for
intervention
because
relatively
targeted
modifications
small
set
potential
improve
health
multiple
systems.
Therefore,
anti-aging
targeting
therapies
represent
potent
approach
improving
healthspan.
Here,
we
review
major
components
summarize
current
immune-targeting
context
discuss
future
directions
field
rejuvenation.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Июнь 8, 2023
Abstract
Aging
is
characterized
by
systemic
chronic
inflammation,
which
accompanied
cellular
senescence,
immunosenescence,
organ
dysfunction,
and
age-related
diseases.
Given
the
multidimensional
complexity
of
aging,
there
an
urgent
need
for
a
systematic
organization
inflammaging
through
dimensionality
reduction.
Factors
secreted
senescent
cells,
known
as
senescence-associated
secretory
phenotype
(SASP),
promote
inflammation
can
induce
senescence
in
normal
cells.
At
same
time,
accelerates
immune
resulting
weakened
function
inability
to
clear
cells
inflammatory
factors,
creates
vicious
cycle
senescence.
Persistently
elevated
levels
organs
such
bone
marrow,
liver,
lungs
cannot
be
eliminated
leading
damage
aging-related
Therefore,
has
been
recognized
endogenous
factor
elimination
could
potential
strategy
anti-aging.
Here
we
discuss
at
molecular,
cellular,
organ,
disease
levels,
review
current
aging
models,
implications
cutting-edge
single
cell
technologies,
well
anti-aging
strategies.
Since
preventing
alleviating
diseases
improving
overall
quality
life
are
ultimate
goals
research,
our
highlights
critical
features
mechanisms
along
with
latest
developments
future
directions
providing
theoretical
foundation
novel
practical
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Май 13, 2023
Abstract
Infection
susceptibility,
poor
vaccination
efficacy,
age-related
disease
onset,
and
neoplasms
are
linked
to
innate
adaptive
immune
dysfunction
that
accompanies
aging
(known
as
immunosenescence).
During
aging,
organisms
tend
develop
a
characteristic
inflammatory
state
expresses
high
levels
of
pro-inflammatory
markers,
termed
inflammaging.
This
chronic
inflammation
is
typical
phenomenon
immunosenescence
it
considered
the
major
risk
factor
for
diseases.
Thymic
involution,
naïve/memory
cell
ratio
imbalance,
dysregulated
metabolism,
epigenetic
alterations
striking
features
immunosenescence.
Disturbed
T-cell
pools
antigen
stimulation
mediate
premature
senescence
cells,
senescent
cells
proinflammatory
senescence-associated
secretory
phenotype
exacerbates
Although
underlying
molecular
mechanisms
remain
be
addressed,
well
documented
T
inflammaging
might
driving
forces
in
Potential
counteractive
measures
will
discussed,
including
intervention
cellular
metabolic-epigenetic
axes
mitigate
In
recent
years,
has
attracted
increasing
attention
its
role
tumor
development.
As
result
limited
participation
elderly
patients,
impact
on
cancer
immunotherapy
unclear.
Despite
some
surprising
results
from
clinical
trials
drugs,
necessary
investigate
other
