Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Март 8, 2025
Abstract
Maternal
exposure
to
particulate
air
pollution
increases
the
incidence
and
severity
of
asthma
in
offspring,
yet
mechanisms
for
this
are
unclear.
Known
susceptibility
loci
a
minor
component
effect.
We
interrogate
mouse
allergic
airway
disease
model
assess
epigenetic
associations
between
maternal
responses
offspring.
increased
adult
offspring
associated
with
suppressed
transcriptomic
response.
Control
progeny
showed
differential
expression
2842
genes
across
several
important
pathways,
whilst
pollutant
an
80%
reduction
differentially
expressed
abrogation
many
pathway
associations.
Whole
genome
CpG
methylome
analysis
following
allergen
challenge
detected
methylation
regions
genome.
Differentially
methylated
were
markedly
reduced
was
most
evident
intronic
some
transposable
element
classes.
This
study
shows
that
PM
2.5
exposed
mothers
had
repressed
response,
proportion
which
identifiable
changes
lung’s
methylome.
The
results
point
contribution
pollution.
Journal of Internal Medicine,
Год журнала:
2022,
Номер
292(3), С. 390 - 408
Опубликована: Апрель 11, 2022
DNA
methylation
is
an
epigenetic
modification
that
has
consistently
been
shown
to
be
linked
with
a
variety
of
human
traits
and
diseases.
Because
dynamic
potentially
reversible
in
nature
can
reflect
environmental
exposures
predict
the
onset
diseases,
it
piqued
interest
as
potential
disease
biomarker.
patterns
are
more
stable
than
transcriptomic
or
proteomic
patterns,
they
relatively
easy
measure
track
exposure
different
environments
risk
factors.
Importantly,
technologies
for
quantification
have
become
increasingly
cost
effective-accelerating
new
research
field-and
enabled
development
novel
biomarkers.
Quite
few
methylation-based
predictors
number
diseases
already
exist.
Such
show
being
accurate
self-reported
measured
phenotypes
(such
smoking
behavior
body
mass
index)
may
even
hold
applications
clinics.
In
this
review,
we
will
first
discuss
advantages
challenges
biomarkers
general.
We
then
review
current
state
future
two
rather
consistent
alterations
methylome-obesity
smoking.
Lastly,
briefly
speculate
about
prospects
biomarkers,
possible
ways
achieve
them.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(9), С. 4671 - 4671
Опубликована: Апрель 23, 2022
Parental
environmental
experiences
affect
disease
susceptibility
in
the
progeny
through
epigenetic
inheritance.
Pesticides
are
substances
or
mixtures
of
chemicals—some
which
persistent
pollutants—that
used
to
control
pests.
This
review
explores
evidence
linking
parental
exposure
pesticides
and
endocrine
disruptors
intergenerational
transgenerational
cancer
population
studies
animal
models.
We
also
discuss
impact
other
on
germline
epigenome
as
well
emerging
for
how
information
is
transmitted
between
generations.
Finally,
we
importance
this
mode
inheritance
context
prevention
challenges
ahead.
Circulation,
Год журнала:
2022,
Номер
146(14), С. 1082 - 1095
Опубликована: Авг. 25, 2022
Adverse
environmental
exposure
during
the
prenatal
period
can
lead
to
diseases
in
offspring,
including
hypertension.
Whether
or
not
hypertensive
phenotype
be
transgenerationally
transmitted
is
known.Pregnant
Sprague
Dawley
rats
were
intraperitoneally
injected
with
lipopolysaccharide
(LPS)
on
gestation
days
6,
8,
10,
and
12
generate
LPS
model.
Blood
pressure
was
monitored
by
both
telemetry
tail-cuff
method.
RNA
sequencing
performed
analyze
transcriptome
alteration
kidney
of
third
generation.
Tempol
spironolactone
used
test
potential
preventative
therapeutic
effect
targeting
reactive
oxygen
species
mineralocorticoid
receptor
signaling,
respectively.
Molecular
biological
experiments
illustrate
mechanism
epigenetic
transcription
regulation.Prenatal
impair
ability
excrete
a
salt
load
induce
hypertension
from
first
generations,
fourth
fifth
inducing
salt-sensitive
Compared
control
pups,
third-generation
LPS-exposed
offspring
have
upregulation
Ras-related
C3
botulinum
toxin
substrate
1
(Rac1)
gene
activation
signaling.
Furthermore,
we
found
that
pregnancy
triggered
oxidative
stress
upregulated
KDM3B
(histone
lysine
demethylase
3B)
oocytes
first-generation
female
rats,
leading
an
inheritable
low
level
H3K9me2
H3
9
dimethylation),
resulting
transgenerational
Rac1.
Based
these
findings,
treated
pregnant
scavenger,
tempol,
which
successfully
prevented
inheritance
hypertension.These
findings
show
adverse
induces
through
epigenetic-regulated
identify
potentially
preventive
strategies
for
