International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3284 - 3284
Опубликована: Март 14, 2024
The
long-term
effects
of
environmental
pollution
have
been
concern
as
several
pollutants
are
carcinogenic,
potentially
inducing
a
variety
cancers,
including
childhood
cancer,
which
is
leading
cause
death
around
the
world
and,
thus,
public
health
issue.
present
scoping
review
aimed
to
update
and
summarize
available
literature
detect
specific
their
association
with
certain
types
cancer.
Studies
published
from
2013
2023
regarding
cancer
were
retrieved
PubMed
database.
A
total
174
studies
eligible
for
this
analyzed.
Our
search
strategy
brought
up
most
articles
that
evaluated
air
(29%)
pesticides
(28%).
Indoor
exposure
chemicals
(11%),
alcohol
tobacco
use
during
pregnancy
(16%),
electromagnetic
fields
(12%),
radon
(4%)
subjects
less
research.
We
found
particularly
high
percentage
positive
associations
between
prenatal
postnatal
indoor
(84%)
outdoor
(79%)
pollution,
well
(82%),
Positive
leukemia
(33%
27%);
CNS
tumors
neuroblastoma
(53%
43%);
Wilms
tumor
other
rare
cancers
in
(50%).
was
mostly
reported
assessing
(26%).
Further
needed
investigate
mechanisms
underlying
potential
indoor/outdoor
pesticide
risk
more
preventable
measures
could
be
taken.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(24), С. 10470 - 10481
Опубликована: Июнь 6, 2024
Rural
workers
are
disproportionally
exposed
to
pesticides
and
might
be
at
an
increased
risk
of
developing
chronic
diseases.
Here,
we
investigated
the
impact
pesticide
exposure
on
breast
cancer
(BC)
disease
profile
in
rural
female
workers.
This
is
a
case-control
study
that
prospectively
included
758
individuals.
The
was
conducted
Southwest
region
Paraná
state
Brazil,
characterized
by
family-based
agriculture
intensive
use
pesticides.
We
found
this
has
41%
higher
BC
diagnosis
rate
14%
mortality
than
mean
rates
as
well
trade
volume
about
6
times
national
average.
showed
substantial
population
even
women
who
did
not
work
fields
but
performed
equipment
decontamination
clothes
washing
male
partners
worked
had
urine
samples
positive
for
glyphosate,
atrazine,
and/or
2,4-D.
crude
association
significantly
among
(OR:
1.58,
95%
CI
1.18–2.13).
Adjusted
analyses
lower
nonstatistically
significant
1.30,
41
0.87–1.95).
Stratification
lymph
node
metastasis
(adjusted
OR:
2.19,
1.31–3.72)
Our
findings
suggest
populations
with
more
aggressive
draw
attention
need
monitor
potentially
field
or
home.
Brain Sciences,
Год журнала:
2024,
Номер
14(5), С. 471 - 471
Опубликована: Май 7, 2024
Plastic
production,
which
exceeds
one
million
tons
per
year,
is
of
global
concern.
The
constituent
low-density
polymers
enable
spread
over
large
distances
and
micro/nano
particles
(MNPLs)
induce
organ
toxicity
via
digestion,
inhalation,
skin
contact.
Particles
have
been
documented
in
all
human
tissues
including
breast
milk.
MNPLs,
especially
weathered
particles,
can
breach
the
blood–brain
barrier,
inducing
neurotoxicity.
This
has
non-human
species,
human-induced
pluripotent
stem
cell
lines.
Within
brain,
MNPLs
initiate
an
inflammatory
response
with
pro-inflammatory
cytokine
oxidative
stress
generation
reactive
oxygen
mitochondrial
dysfunction.
Glutamate
GABA
neurotransmitter
dysfunction
also
ensues
alteration
excitatory/inhibitory
balance
favor
reduced
inhibition
resultant
neuro-excitation.
Inflammation
cortical
hyperexcitability
are
key
abnormalities
involved
pathogenic
cascade
amyotrophic
lateral
sclerosis
(ALS)
intricately
related
to
mislocalization
aggregation
TDP-43,
a
hallmark
ALS.
Water
many
foods
contain
humans,
ingestion
main
form
exposure.
Digestion
plastics
within
gut
alter
their
properties,
rendering
them
more
toxic,
they
cause
microbiome
dysbiosis
dysfunctional
gut–brain
axis.
recognized
as
trigger
and/or
aggravating
factor
for
ALS
associated
long
(years
or
decades)
preclinical
period
neonates
infants
exposed
through
milk,
milk
substitutes,
toys.
endangers
time
intense
neurogenesis
establishment
neuronal
circuitry,
setting
stage
development
neurodegeneration
later
life.
MNPL
neurotoxicity
should
be
considered
yet
unrecognized
risk
diseases.
Molecular Biology and Evolution,
Год журнала:
2025,
Номер
42(1)
Опубликована: Янв. 1, 2025
Abstract
The
molecular
basis
of
adaptive
evolution
and
cancer
progression
are
both
complex
processes
that
share
many
striking
similarities.
potential
significance
environmentally-induced
epigenetic
changes
is
currently
an
area
great
interest
in
evolutionary
biology.
In
the
field
biology
intense
effort
has
been
focused
on
contribution
stress-induced
non-coding
RNAs
(ncRNAs)
activation
associated
with
elevated
mutation
rates
acquisition
environmentally
traits.
Examples
this
process
presented
combined
more
recent
findings
demonstrating
ncRNAs
transferable
from
somatic
to
germline
cells
leading
cross-generational
inheritance
acquired
fact
have
implicated
transient
response
various
plants
animals
environmental
stress
consistent
Based
these
collective
observations,
a
general
model
as
well
specific
testable
hypotheses
proposed
how
ncRNA-mediated
responses
may
facilitate
transition
long-term
biological
adaptation
evolution.
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 1, 2025
The
widespread
application
of
pesticides
in
agriculture
and
the
consequent
heightened
human
exposure
to
these
potentially
harmful
substances
present
considerable
environmental
health
risks.
potential
link
cancer
is
particularly
concerning,
underscoring
urgent
need
for
more
sustainable
health-conscious
agricultural
practices.
Pesticides
are
pervasive
global
contaminants,
with
occurring
through
various
routes.
Improper
use
associated
genotoxicity,
neurobehavioral
problems,
thyroid
dysfunction,
reproductive
issues,
cancer,
among
other
deleterious
damages.
While
pesticide
evident
Chile,
a
direct
remains
uncertain.
To
examine
scientific
evidence
on
environment
populations,
its
relationship
Chilean
territory.
search
original
articles
was
performed
international
peer-reviewed
databases,
including
Scopus,
Web
Science
(WoS),
PubMed
Advanced
Search
Builder.
Following
PRISMA
extension
review
guidelines,
included
studies
exposure,
biomarker
assessments,
experimental
investigations,
pesticide-cancer
associations
Chile.
Foreign
studies,
systematic
reviews,
meta-analyses
were
excluded.
Among
83
qualifying
conducted
between
1996
2024,
elevated
risks
documented,
71%
indicating
high
concentrations
that
may
pose
risk.
Additionally,
20%
reported
significant
chlorinated
compounds,
organochlorines
(OCs)
polychlorinated
biphenyls
(PCBs),
while
79.5%
identified
carcinogenic
humans
classified
by
International
Agency
Research
Cancer.
emphasizes
update
pesticide-related
regulations
implementing
bans
or
restrictions
establishing
stricter
standards
allowable
residue
levels
food.
Long-term
epidemiological
essential
concrete
links
specific
types
cancer.
investigating
epigenetic
markers
especially
occupational
settings,
critical.
Furthermore,
allocating
resources
prioritizing
further
research
fundamental,
regions
substantial
exposure.
Toxics,
Год журнала:
2022,
Номер
10(11), С. 676 - 676
Опубликована: Ноя. 9, 2022
Pesticide
exposure
has
deleterious
effects
on
human
health
and
development;
however,
no
review
been
conducted
to
pesticides
the
risk
of
congenital
malformations
cancer
in
same
cohort.
We
systematically
reviewed
evidence
for
this
relationship
following
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analysis
guidelines.
Four
databases,
namely,
PubMed,
Scopus,
Cochrane
Library,
BVS,
were
searched
studies
deposited
till
July
2020
that
examined
influence
pesticide
outcomes
Seven
included
review.
Among
these,
four
case-control
studies,
two
cross-sectional
one
was
a
longitudinal
cohort
study.
The
sources
contamination
food,
water,
or
during
agricultural
work.
A
link
between
occurrence
cancer,
malformations,
observed
most
studies.
Toxics,
Год журнала:
2023,
Номер
11(9), С. 725 - 725
Опубликована: Авг. 24, 2023
Persistent
Organic
Pollutants
(POPs)
such
as
dichlorodimethyltrichloroethane
(DDT)
are
present
and
ubiquitous
in
the
environment
due
to
their
resilient
nature.
DDT
is
a
prevalent
endocrine
disruptor
still
found
detectable
amounts
organisms
even
after
its
use
was
banned
1970s.
Medline
Google
Scholar
were
systematically
searched
detect
all
relevant
animal
human
studies
published
last
20
years
(January
2003
February
2023)
accordance
with
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
(PRISMA)
statement.
In
total,
38
included
qualitative
synthesis.
This
systematic
search
review
indicated
that
exposure
associated
female
reproductive
health
issues,
reduced
fecundability;
increased
risk
of
preterm/premature
deliveries;
periods
gestation;
alterations
synthesis
crucial
hormones
(Progesterone
Oxytocin)
through
ion
imbalances
changes
prostaglandin
synthesis,
myometrial
stromal
hypertrophy,
edema;
variations
uterine
contractions
wet
weight.
There
also
limited
evidence
indicating
carcinogen
sufficient
instigate
cancers.
However,
this
only
takes
into
account
vitro
have
established
possible
pathway
understand
how
impacts
infertility
leads
Links
between
pathways
described
various
been
developed
produce
summarized
picture
one
event
might
lead
another.
Additionally,
epidemiological
specifically
targeted
females
belonging
ethnicities
reviewed
develop
an
overall
prevailing
concerns
different
nations.
