Atherosclerosis: Recent developments

Cell, Год журнала: 2022, Номер 185(10), С. 1630 - 1645

Опубликована: Май 1, 2022

Atherosclerosis is an inflammatory disease of the large arteries that major cause cardiovascular (CVD) and stroke. Here, we review current understanding molecular, cellular, genetic, environmental contributions to atherosclerosis, from both individual pathway systems perspectives. We place emphasis on recent developments, some which have yielded unexpected biology, including previously unknown heterogeneity smooth muscle cells in atherosclerotic lesions, roles for senescence clonal hematopoiesis, links gut microbiome.

Язык: Английский

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Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Апрель 22, 2022

Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing clinical trials have demonstrated that innate adaptive immune responses can promote or quell atherosclerosis. Several signaling pathways, are associated the response, been implicated within atherosclerosis such as NLRP3 inflammasome, toll-like receptors, proprotein convertase subtilisin/kexin type 9, Notch Wnt which of importance for development regression. Targeting especially inflammasome pathway its regulated cytokine interleukin-1β, could represent an attractive new route treatment atherosclerotic diseases. Herein, we summarize knowledge on cellular participants key pathways in atherosclerosis, discuss preclinical studies targeting these going to target some processes, effects quelling inflammation clinic.

Язык: Английский

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Metformin: update on mechanisms of action and repurposing potential

Nature Reviews Endocrinology, Год журнала: 2023, Номер 19(8), С. 460 - 476

Опубликована: Май 2, 2023

Язык: Английский

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Atherosclerosis: Known and unknown

Pathology International, Год журнала: 2022, Номер 72(3), С. 151 - 160

Опубликована: Янв. 25, 2022

Atherosclerotic disease, such as myocardial infarction and stroke, is the number one killer worldwide. Atherosclerosis considered to be caused by multiple factors, including genetic environmental factors. In humans, it takes several decades until clinical complications develop. There are many known risk factors for atherosclerosis, hypercholesterolemia, hypertension, diabetes smoking, which involved in pathogenesis of atherosclerosis; however, generally believed that atherosclerosis vascular chronic inflammation initiated interactions these arterial wall cells. past 30 years, molecular mechanisms underlying have been investigated extensively using genetically modified animals, lipid-reducing drugs, statins, demonstrated most effective prevention treatment atherosclerosis. However, despite this progress, questions regarding remain there a need develop new animal models novel therapeutics treat patients who cannot effectively treated statins. review, we will focus on two topics "pathology" "pathogenesis," discuss unanswered questions.

Язык: Английский

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Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

Nature Reviews Cardiology, Год журнала: 2022, Номер 19(8), С. 522 - 542

Опубликована: Янв. 31, 2022

Язык: Английский

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RNA modifications: importance in immune cell biology and related diseases

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Сен. 22, 2022

RNA modifications have become hot topics recently. By influencing processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune abnormality in human diseases is also a research focus progressing rapidly these years. Studies demonstrated that participate the multiple biological processes cells, development, differentiation, activation, migration, polarization, thereby modulating responses are involved some related diseases. In this review, we present existing knowledge functions underlying mechanisms modifications, N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), N4-acetylcytosine (ac4C), pseudouridine (Ψ), uridylation, adenosine-to-inosine (A-to-I) editing, summarize their roles Via regulating can pathogenesis diseases, such cancers, infection, inflammatory autoimmune We further highlight challenges future directions based on knowledge. All all, review will provide helpful well novel ideas for researchers area.

Язык: Английский

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Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7910 - 7910

Опубликована: Апрель 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Язык: Английский

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Inflammation Resolution: Implications for Atherosclerosis

Circulation Research, Год журнала: 2022, Номер 130(1), С. 130 - 148

Опубликована: Янв. 7, 2022

Resolution is an active and highly coordinated process that occurs in response to inflammation limit tissue damage promote repair. When the resolution program fails, persists. It now understood failed a major underlying cause of many chronic inflammatory diseases. Here, we will review failures atherosclerosis, including imbalance proinflammatory pro-resolving mediator production, impaired clearance dead cells, functional changes immune cells favor ongoing inflammation. In addition, briefly discuss new concepts are emerging as possible regulators highlight translational significance for field.

Язык: Английский

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Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism

Nature Metabolism, Год журнала: 2022, Номер 4(10), С. 1271 - 1286

Опубликована: Окт. 17, 2022

Язык: Английский

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A bibliometric analysis of T cell and atherosclerosis

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Окт. 13, 2022

Atherosclerosis (AS) is widespread and develops into circulatory system problems. T cells play an essential regulatory role in AS occurrence development. So far, there no bibliometric research on AS. To learn more about cell development, 4,381 records were retrieved from Web of Science™ Core Collection. Then, these scientometrically analyzed using CiteSpace VOSviewer terms spatiotemporal distribution, author subject categories, topic references, keywords. Our analysis provides basic information the field, demonstrates that field has stabilized over past decade, identifies potential partners for interested researchers. Current hotspots this mainly include inflammatory mechanism, immune related diseases, cytokines B cell, mortality, inhibition, monocyte represent frontiers undergoing explosive phase. We hope work will provide new ideas advancing scientific clinical application

Язык: Английский

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