Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Март 8, 2024
Abstract
2D
materials
(2DMs),
such
as
graphene,
transition
metal
dichalcogenides
(TMDs),
and
black
phosphorus
(BP),
have
been
proposed
for
different
types
of
bioapplications,
owing
to
their
unique
physicochemical,
electrical,
optical,
mechanical
properties.
Liquid
phase
exfoliation
(LPE),
one
the
most
effective
up‐scalable
size‐controllable
methods,
is
becoming
standard
process
produce
high
quantities
various
2DM
it
can
benefit
from
use
green
biocompatible
conditions.
The
resulting
exfoliated
layered
garnered
significant
attention
because
biocompatibility
potential
in
biomedicine
new
multimodal
therapeutics,
antimicrobials,
biosensors.
This
review
focuses
on
production
LPE‐assisted
2DMs
aqueous
solutions
with
or
without
aid
surfactants,
bioactive,
non‐natural
molecules,
providing
insights
into
possibilities
applications
biological
biomedical
fields.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(3), С. 1685 - 1685
Опубликована: Фев. 1, 2022
The
advent
of
cancer
therapeutics
brought
a
paradigm
shift
from
conventional
therapy
to
precision
medicine.
new
therapeutic
modalities
accomplished
through
the
properties
nanomaterials
have
extended
their
scope
in
beyond
drug
delivery.
Nanoparticles
can
be
channeled
encapsulate
active
pharmaceutical
ingredients
and
deliver
them
tumor
site
more
efficient
manner.
This
review
enumerates
various
types
nanoparticles
that
entered
clinical
trials
for
treatment.
obstacles
journey
nanodrug
clinic
market
are
reviewed.
Furthermore,
latest
developments
using
also
highlighted.
Advanced Materials,
Год журнала:
2022,
Номер
34(20)
Опубликована: Март 22, 2022
Therapeutic
mRNA
vaccination
is
an
attractive
approach
to
trigger
antitumor
immunity.
However,
the
delivery
technology
for
customized
tumor
vaccine
still
limited.
In
this
work,
bacteria-derived
outer
membrane
vesicles
(OMVs)
are
employed
as
platform
by
genetically
engineering
with
surface
decoration
of
RNA
binding
protein,
L7Ae,
and
lysosomal
escape
listeriolysin
O
(OMV-LL).
OMV-LL
can
rapidly
adsorb
box
C/D
sequence-labelled
antigens
through
L7Ae
(OMV-LL-mRNA)
deliver
them
into
dendritic
cells
(DCs),
following
cross-presentation
via
O-mediated
endosomal
escape.
OMV-LL-mRNA
significantly
inhibits
melanoma
progression
elicits
37.5%
complete
regression
in
a
colon
cancer
model.
induces
long-term
immune
memory
protects
mice
from
challenge
after
60
days.
summary,
provides
distinct
lipid
nanoparticles
(LNPs)
personalized
vaccination,
"Plug-and-Display"
strategy
that
enables
its
versatile
application
vaccines.
ACS Nano,
Год журнала:
2021,
Номер
15(8), С. 12567 - 12603
Опубликована: Авг. 2, 2021
Immunotherapy
that
harnesses
the
human
immune
system
to
fight
cancer
has
received
widespread
attention
and
become
a
mainstream
strategy
for
treatment.
Cancer
immunotherapy
not
only
eliminates
primary
tumors
but
also
treats
metastasis
recurrence,
representing
major
advantage
over
traditional
treatments.
Recently
with
development
of
nanotechnology,
there
exists
much
work
applying
nanomaterials
on
basis
their
excellent
physiochemical
properties,
such
as
efficient
tissue-specific
delivery
function,
huge
specific
surface
area,
controllable
chemistry.
Consequently,
nanotechnology
holds
significant
potential
in
improving
efficacy
immunotherapy.
Nanotechnology-based
mainly
manifests
its
inhibitory
effect
via
two
different
approaches:
one
is
produce
an
effective
anti-tumor
response
during
tumorigenesis,
other
enhance
tumor
defense
ability
by
modulating
suppression
mechanism
microenvironment.
With
success
immunotherapy,
understanding
interaction
between
smart
nanomedicine
provided
vigorous
vitality
This
review
highlights
application,
progress,
prospect
process
immunoediting
discusses
several
engineering
methods
improve
efficiency
ACS Applied Nano Materials,
Год журнала:
2021,
Номер
4(7), С. 6471 - 6496
Опубликована: Июль 2, 2021
Nanoparticle
size
plays
a
central
role
in
determining
material
properties
and
performance
biomedical
applications.
A
wide
variety
of
functional
nanomaterials
nano-bioconjugates
have
been
developed
for
monitoring
biochemical
activity,
controlling
biological
functions,
therapeutic
This
review
focuses
on
the
nanoparticle
(typically
range
1–100
nm)
various
applications,
origin
such
effect,
optimum
requirement
best
different
First,
we
discuss
nanoscale
units
present
life
processes
along
with
their
role.
Next,
size-dependent
some
well-known
nanoparticles
how
those
are
exploited
that
used
Then,
highlight
designed
specific
Finally,
attempt
to
correlate
evolutionary
selection
toward
functions.
ACS Nano,
Год журнала:
2022,
Номер
16(8), С. 13037 - 13048
Опубликована: Июль 21, 2022
Overproduction
of
reactive
oxygen
species
(ROS),
a
key
characteristic
inflammatory
bowel
disease
(IBD),
is
responsible
for
dysregulation
signal
transduction,
response,
and
DNA
damage,
which
ultimately
leads
to
progression
deterioration.
Thus,
ROS
scavenging
has
become
promising
strategy
navigate
IBD.
Inspired
by
the
targeting
capability
hyaluronic
acid
(HA)
CD44-overexpressed
cells
together
with
redox
regulation
capacity
diselenide
compounds,
we
developed
an
oral
nanoformulation,
i.e.,
diselenide-bridged
nanogel
(SeNG),
view
treat
colitis
through
mechanism.
Our
data
demonstrated
that
SeNG
specifically
accumulated
in
tissue
was
mediated
highly
efficient
CD44–HA
interaction.
This
allowed
us
demonstrate
significant
anti-inflammatory
effect
acute
mouse
model
induced
dextran
sulfate
sodium
trinitrobenzenesulfonic
acid.
Mechanistically,
continued
show
reduced
level
via
both
direct
elimination
up-regulation
Nrf2/HO-1
pathway.
Collectively,
our
work
provides
proof-of-principle
evidence
SeNG-mediated
nano-antioxidant
strategy,
could
be
effectively
managed.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23223 - 23261
Опубликована: Дек. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
