ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(14), P. 12971 - 12999
Published: July 11, 2023
Swarms,
which
stem
from
collective
behaviors
among
individual
elements,
are
commonly
seen
in
nature.
Since
two
decades
ago,
scientists
have
been
attempting
to
understand
the
principles
of
natural
swarms
and
leverage
them
for
creating
artificial
swarms.
To
date,
underlying
physics;
techniques
actuation,
navigation,
control;
field-generation
systems;
a
research
community
now
place.
This
Review
reviews
fundamental
applications
micro/nanorobotic
The
generation
mechanisms
emergent
micro/nanoagents
identified
over
past
elucidated.
advantages
drawbacks
different
techniques,
existing
control
systems,
major
challenges,
potential
prospects
discussed.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1685 - 1685
Published: Feb. 1, 2022
The
advent
of
cancer
therapeutics
brought
a
paradigm
shift
from
conventional
therapy
to
precision
medicine.
new
therapeutic
modalities
accomplished
through
the
properties
nanomaterials
have
extended
their
scope
in
beyond
drug
delivery.
Nanoparticles
can
be
channeled
encapsulate
active
pharmaceutical
ingredients
and
deliver
them
tumor
site
more
efficient
manner.
This
review
enumerates
various
types
nanoparticles
that
entered
clinical
trials
for
treatment.
obstacles
journey
nanodrug
clinic
market
are
reviewed.
Furthermore,
latest
developments
using
also
highlighted.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(20)
Published: March 22, 2022
Therapeutic
mRNA
vaccination
is
an
attractive
approach
to
trigger
antitumor
immunity.
However,
the
delivery
technology
for
customized
tumor
vaccine
still
limited.
In
this
work,
bacteria-derived
outer
membrane
vesicles
(OMVs)
are
employed
as
platform
by
genetically
engineering
with
surface
decoration
of
RNA
binding
protein,
L7Ae,
and
lysosomal
escape
listeriolysin
O
(OMV-LL).
OMV-LL
can
rapidly
adsorb
box
C/D
sequence-labelled
antigens
through
L7Ae
(OMV-LL-mRNA)
deliver
them
into
dendritic
cells
(DCs),
following
cross-presentation
via
O-mediated
endosomal
escape.
OMV-LL-mRNA
significantly
inhibits
melanoma
progression
elicits
37.5%
complete
regression
in
a
colon
cancer
model.
induces
long-term
immune
memory
protects
mice
from
challenge
after
60
days.
summary,
provides
distinct
lipid
nanoparticles
(LNPs)
personalized
vaccination,
"Plug-and-Display"
strategy
that
enables
its
versatile
application
vaccines.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(8), P. 12567 - 12603
Published: Aug. 2, 2021
Immunotherapy
that
harnesses
the
human
immune
system
to
fight
cancer
has
received
widespread
attention
and
become
a
mainstream
strategy
for
treatment.
Cancer
immunotherapy
not
only
eliminates
primary
tumors
but
also
treats
metastasis
recurrence,
representing
major
advantage
over
traditional
treatments.
Recently
with
development
of
nanotechnology,
there
exists
much
work
applying
nanomaterials
on
basis
their
excellent
physiochemical
properties,
such
as
efficient
tissue-specific
delivery
function,
huge
specific
surface
area,
controllable
chemistry.
Consequently,
nanotechnology
holds
significant
potential
in
improving
efficacy
immunotherapy.
Nanotechnology-based
mainly
manifests
its
inhibitory
effect
via
two
different
approaches:
one
is
produce
an
effective
anti-tumor
response
during
tumorigenesis,
other
enhance
tumor
defense
ability
by
modulating
suppression
mechanism
microenvironment.
With
success
immunotherapy,
understanding
interaction
between
smart
nanomedicine
provided
vigorous
vitality
This
review
highlights
application,
progress,
prospect
process
immunoediting
discusses
several
engineering
methods
improve
efficiency
ACS Applied Nano Materials,
Journal Year:
2021,
Volume and Issue:
4(7), P. 6471 - 6496
Published: July 2, 2021
Nanoparticle
size
plays
a
central
role
in
determining
material
properties
and
performance
biomedical
applications.
A
wide
variety
of
functional
nanomaterials
nano-bioconjugates
have
been
developed
for
monitoring
biochemical
activity,
controlling
biological
functions,
therapeutic
This
review
focuses
on
the
nanoparticle
(typically
range
1–100
nm)
various
applications,
origin
such
effect,
optimum
requirement
best
different
First,
we
discuss
nanoscale
units
present
life
processes
along
with
their
role.
Next,
size-dependent
some
well-known
nanoparticles
how
those
are
exploited
that
used
Then,
highlight
designed
specific
Finally,
attempt
to
correlate
evolutionary
selection
toward
functions.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(8), P. 13037 - 13048
Published: July 21, 2022
Overproduction
of
reactive
oxygen
species
(ROS),
a
key
characteristic
inflammatory
bowel
disease
(IBD),
is
responsible
for
dysregulation
signal
transduction,
response,
and
DNA
damage,
which
ultimately
leads
to
progression
deterioration.
Thus,
ROS
scavenging
has
become
promising
strategy
navigate
IBD.
Inspired
by
the
targeting
capability
hyaluronic
acid
(HA)
CD44-overexpressed
cells
together
with
redox
regulation
capacity
diselenide
compounds,
we
developed
an
oral
nanoformulation,
i.e.,
diselenide-bridged
nanogel
(SeNG),
view
treat
colitis
through
mechanism.
Our
data
demonstrated
that
SeNG
specifically
accumulated
in
tissue
was
mediated
highly
efficient
CD44–HA
interaction.
This
allowed
us
demonstrate
significant
anti-inflammatory
effect
acute
mouse
model
induced
dextran
sulfate
sodium
trinitrobenzenesulfonic
acid.
Mechanistically,
continued
show
reduced
level
via
both
direct
elimination
up-regulation
Nrf2/HO-1
pathway.
Collectively,
our
work
provides
proof-of-principle
evidence
SeNG-mediated
nano-antioxidant
strategy,
could
be
effectively
managed.
