Microbiome and cancer

Cancer Cell, Год журнала: 2021, Номер 39(10), С. 1317 - 1341

Опубликована: Сен. 9, 2021

Язык: Английский

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The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly

The Lancet Microbe, Год журнала: 2022, Номер 3(12), С. e969 - e983

Опубликована: Сен. 29, 2022

Язык: Английский

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The oral microbiome: diversity, biogeography and human health

Nature Reviews Microbiology, Год журнала: 2023, Номер 22(2), С. 89 - 104

Опубликована: Сен. 12, 2023

Язык: Английский

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The gut virome: A new microbiome component in health and disease

EBioMedicine, Год журнала: 2022, Номер 81, С. 104113 - 104113

Опубликована: Июнь 23, 2022

The human gastrointestinal tract harbours an abundance of viruses, collectively known as the gut virome. virome is highly heterogeneous across populations and linked to geography, ethnicity, diet, lifestyle, urbanisation. currently function varies greatly populations, much remains unknown. We review current literature on virome, intricate trans-kingdom interplay among bacteria, mammalian host underlying health diseases. summarise evidence use diagnostic markers a therapeutic target. shed light novel avenues microbiome-inspired diagnosis therapies. also pre-clinical clinical studies virome-rectification-based therapies, including faecal microbiota transplantation, refined phage therapy. Our suggests that future research effort should focus unravelling mechanisms exerted by viruses/phages in pathophysiology, developing phage-prompted precision

Язык: Английский

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Microbiota succession throughout life from the cradle to the grave

Nature Reviews Microbiology, Год журнала: 2022, Номер 20(12), С. 707 - 720

Опубликована: Июль 29, 2022

Язык: Английский

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Gut Microbiome Alterations in COVID-19

Genomics Proteomics & Bioinformatics, Год журнала: 2021, Номер 19(5), С. 679 - 688

Опубликована: Сен. 21, 2021

Abstract Since the outset of coronavirus disease 2019 (COVID-19) pandemic, gut microbiome in COVID-19 has garnered substantial interest, given its significant roles human health and pathophysiology. Accumulating evidence is unveiling that broadly altered COVID-19, including bacterial microbiome, mycobiome, virome. Overall, microbial ecological network significantly weakened becomes sparse patients with together a decrease diversity. Beyond existence severe acute respiratory syndrome type 2 (SARS-CoV-2), also characterized by enrichment opportunistic bacteria, fungi, eukaryotic viruses, which are associated severity presentation. Meanwhile, multitude symbiotic bacteria bacteriophages decreased abundance COVID-19. Such features persist subset even after resolution, coinciding ‘long COVID’ (also known as post-acute sequelae COVID-19). The broadly-altered largely consequence SARS-CoV-2infection downstream detrimental effects on systemic host immunity milieu. impaired distorted ecology, particularly loss low-abundance beneficial blooms fungi Candida, may hinder reassembly post Future investigation necessary to fully understand role against SARS-CoV-2 infection, well long-term effect relation pandemic.

Язык: Английский

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The neurobiology of irritable bowel syndrome

Molecular Psychiatry, Год журнала: 2023, Номер 28(4), С. 1451 - 1465

Опубликована: Фев. 2, 2023

Abstract Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that affects between 5 and 10% general population worldwide. The current symptom criteria restrict diagnosis to recurrent abdominal pain associated with altered habits, but majority patients also report non-painful discomfort, psychiatric conditions (anxiety depression), as well other visceral somatic pain-related symptoms. For decades, IBS was considered an intestinal motility disorder, more recently a gut disorder. However, based on extensive body reported information about central, peripheral mechanisms genetic factors involved in pathophysiology symptoms, comprehensive disease model brain-gut-microbiome has emerged, which can explain chronic pain, comorbidities. In this review, we will first describe novel insights into several key components microbiome interactions, starting alterations connectome enteric nervous system, list distinct functional structural brain signatures, comparing them proposed anxiety disorders. We then point out emerging correlations networks genomic, gastrointestinal, immune, microbiome-related parameters. incorporate new systems-based IBS. Finally, discuss implications such for improved understanding development effective treatment approaches future.

Язык: Английский

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Lung microbiome: new insights into the pathogenesis of respiratory diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Янв. 17, 2024

The lungs were long thought to be sterile until technical advances uncovered the presence of lung microbial community. microbiome healthy is mainly derived from upper respiratory tract (URT) but also has its own characteristic flora. selection mechanisms in lung, including clearance by coughing, pulmonary macrophages, oscillation cilia, and bacterial inhibition alveolar surfactant, keep transient mobile, which different other organs. bacteriome been intensively studied recently, relatively little research focused on mycobiome virome. This up-to-date review retrospectively summarizes microbiome's history, composition, function. We focus interaction with oropharynx gut emphasize role it plays innate adaptive immune responses. More importantly, we multiple diseases, asthma, chronic obstructive disease (COPD), fibrosis, bronchiectasis, pneumonia. impact coronavirus 2019 (COVID-19) cancer comprehensively studied. Furthermore, summarizing therapeutic potential diseases examining shortcomings field, propose an outlook direction research.

Язык: Английский

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The interplay between diet and the gut microbiome: implications for health and disease

Nature Reviews Microbiology, Год журнала: 2024, Номер 22(11), С. 671 - 686

Опубликована: Июль 15, 2024

Язык: Английский

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Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 1107 - 1126

Опубликована: Дек. 25, 2022

Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential enhance bioavailability whilst reducing off-target effects. Delivering drugs colon requires considered formulation development, as both oral rectal dosage forms encounter challenges if colon's distinct physiological environment is not appreciated. As opportunities surrounding colonic multiply, success of novel pharmaceuticals lies in their design. This review provides a modern insight into key parameters determining effective design development colon-targeted medicines. Influential features governing release, dissolution, stability, absorption are first discussed, followed by an overview most reliable strategies. Finally, appropriate vitro, vivo, silico preclinical investigations presented, with goal inspiring strategic new therapeutics.

Язык: Английский

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