Microbially mediated metal corrosion

Nature Reviews Microbiology, Год журнала: 2023, Номер 21(11), С. 705 - 718

Опубликована: Июнь 21, 2023

Язык: Английский

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Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms

Antibiotics, Год журнала: 2023, Номер 12(2), С. 328 - 328

Опубликована: Фев. 4, 2023

Most bacteria attach to biotic or abiotic surfaces and are embedded in a complex matrix which is known as biofilm. Biofilm formation especially worrisome clinical settings it hinders the treatment of infections with antibiotics due facilitated acquisition antibiotic resistance genes (ARGs). Environmental now considered pivotal for driving biofilm formation, biofilm-mediated development dissemination. Several studies have demonstrated that environmental biofilms can be hotspots dissemination ARGs. These encoded on mobile genetic elements (MGEs) such conjugative mobilizable plasmids integrative (ICEs). ARGs rapidly transferred through horizontal gene transfer (HGT) has been shown occur more frequently than planktonic cultures. models promising tools mimic natural study via HGT. This review summarizes state-of-the-art techniques visualize three main HGT mechanisms biofilms: transformation, transduction, conjugation.

Язык: Английский

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The potential of biochar as a microbial carrier for agricultural and environmental applications

The Science of The Total Environment, Год журнала: 2023, Номер 886, С. 163968 - 163968

Опубликована: Май 9, 2023

Biochar can be an effective carrier for microbial inoculants because of its favourable properties promoting life. In this review, we assess the effectiveness biochar as a agricultural and environmental applications. is enriched with organic carbon, contains nitrogen, phosphorus, potassium nutrients, has high porosity moisture-holding capacity. The large number active hydroxyl, carboxyl, sulfonic acid group, amino, imino, acylamino hydroxyl carboxyl functional groups are cell adhesion proliferation. use inoculum been shown to enhance persistence, survival colonization inoculated microbes in soil plant roots, which play crucial role biochemical processes, nutrient carbon cycling, contamination remediation. Moreover, biochar-based including probiotics effectively promote growth remediate contaminated pollutants. These findings suggest that serve promising substitute non-renewable substrates, such peat, formulate deliver inoculants. future research directions relation improving material performance expanding potential applications emerging immobilization technology have proposed.

Язык: Английский

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Biofilms: Understanding the structure and contribution towards bacterial resistance in antibiotics

Medicine in Microecology, Год журнала: 2023, Номер 16, С. 100084 - 100084

Опубликована: Май 31, 2023

The biofilm is a bacterial colony wrapped in an auto-produced polymer matrix of polysaccharides, proteins, and DNA. Bacterial biofilms cause persistent infections because they are more resistant to antibiotics, disinfectants, the immune system body. Other significant characteristics gradient oxygen nutrition from top layer bottom biofilms. Lower cell metabolic activity longer doubling rates linked gradients; these quiescent cells responsible for some resistance antibiotics. Biofilms may be avoided cured with vigorous antibiotic prophylaxis or treatment early on continuous suppressive medication. This review discusses development tolerance bacteria due formation, mechanisms, that induce bacteria. Recent strategies combat also discussed.

Язык: Английский

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Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives

Biomedicines, Год журнала: 2023, Номер 11(2), С. 413 - 413

Опубликована: Янв. 31, 2023

The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads millions deaths all over the world. sharing genes between different types bacteria led emergence multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial by up 1000-fold increase MDR infections. absence novel potent antimicrobial compounds linked rise resistance. sparked international efforts develop new improved agents well innovative efficient techniques for administration targeting. There an evolution nanotechnology treatment prevention biofilm formation infection. development nanomaterial-based therapeutics, could overcome current pathways acquired drug resistance, hopeful strategy treating difficult-to-treat Additionally, nanoparticles’ distinct size physical characteristics enable them target biofilms treat pathogens. review highlights advances combat In addition, provides insight on mechanisms XDR infection, nanoparticles their antibacterial activity. Moreover, this considers difference free antibiotics nanoantibiotics, synergistic effect nanoantibiotics planktonic bacteria, intracellular biofilm. Finally, we will discuss strength limitations application against infection future perspectives.

Язык: Английский

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Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Small, Год журнала: 2022, Номер 19(6)

Опубликована: Дек. 5, 2022

Abstract Bacterial biofilm‐related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is low permeability enrichment therapeutic agents within biofilm, which results from particular features matrix barriers such as negatively charged components highly viscous compact EPS structures. Hence, developing novel strategies enhanced penetrability crucial. Herein, current progress nanotechnology methods to improve agents’ against matrix, regulating material morphology surface properties, utilizing physical penetration nano/micromotors microneedle patches, equipping nanoparticles degradation enzymes signal molecules, first summarized. Finally, challenges, perspectives, future implementations engineered delivery systems manage infections presented in detail.

Язык: Английский

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Antibiotic failure: Beyond antimicrobial resistance

Drug Resistance Updates, Год журнала: 2023, Номер 71, С. 101012 - 101012

Опубликована: Окт. 18, 2023

Язык: Английский

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Strategy to combat biofilms: a focus on biofilm dispersal enzymes

npj Biofilms and Microbiomes, Год журнала: 2023, Номер 9(1)

Опубликована: Сен. 7, 2023

Bacterial biofilms, which consist of three-dimensional extracellular polymeric substance (EPS), not only function as signaling networks, provide nutritional support, and facilitate surface adhesion, but also serve a protective shield for the residing bacterial inhabitants against external stress, such antibiotics, antimicrobials, host immune responses. Biofilm-associated infections account 65-80% all human microbial that lead to serious mortality morbidity. Tremendous effort has been spent address problem by developing biofilm-dispersing agents discharge colonized cells more vulnerable planktonic state. Here, we discuss recent progress enzymatic eradicating strategies medical with focus on dispersal mechanisms. Particularly, review three enzyme classes have extensively investigated, namely glycoside hydrolases, proteases, deoxyribonucleases.

Язык: Английский

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Bacterial Biofilm Formation on Biomaterials and Approaches to Its Treatment and Prevention

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11680 - 11680

Опубликована: Июль 20, 2023

Bacterial biofilms can cause widespread infection. In addition to causing urinary tract infections and pulmonary in patients with cystic fibrosis, help microorganisms adhere the surfaces of various medical devices, biofilm-associated on biomaterials such as venous ducts, joint prostheses, mechanical heart valves, catheters. Biofilms provide a protective barrier for bacteria resistance antimicrobial agents, which increases morbidity mortality patients. This review summarizes biofilm formation processes mechanisms, well main features clinically persistent caused by biofilms. Considering clinical we introduce two methods prevent treat biomaterial-related infection: antibacterial coatings surface modification biomaterials. Antibacterial depend covalent immobilization agents coating drug release combat infection, while affects adhesion behavior cells implants subsequent process altering physical chemical properties implant material surface. The advantages each strategy terms their effect, biocompatibility, limitations, application prospects are analyzed, providing ideas research directions development novel infection strategies related therapeutic materials.

Язык: Английский

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Engineering Antimicrobial Metal–Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Ноя. 24, 2023

Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety their synthesis often involves complex procedures modes action are unclear. Herein, simple strategy is reported for designing metal-phenolic network (am-MPN) through one-step assembly seeding agent (diethyldithiocarbamate), natural polyphenols, metal ions (e.g., Cu

Язык: Английский

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