Extracellular matrix remodeling in the tumor immunity DOI Creative Commons
Wei Du,

Xueming Xia,

Fan Hu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 25, 2024

The extracellular matrix (ECM) is a significant constituent of tumors, fulfilling various essential functions such as providing mechanical support, influencing the microenvironment, and serving reservoir for signaling molecules. abundance degree cross-linking ECM components are critical determinants tissue stiffness. In process tumorigenesis, interaction between immune cells within tumor microenvironment (TME) frequently leads to stiffness, thereby disrupting normal mechanotransduction promoting malignant progression. Therefore, acquiring thorough comprehension dysregulation TME would significantly aid in identification potential therapeutic targets cancer treatment. this regard, we have compiled comprehensive summary encompassing following aspects: (1) principal their roles conditions; (2) intricate TME; (3) pivotal regulators governing onco-immune response ECM.

Язык: Английский

Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy DOI
Tian Zhang, Yuanbo Jia, Yang Yu

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 186, С. 114319 - 114319

Опубликована: Май 8, 2022

Язык: Английский

Процитировано

80

Assessing cell migration in hydrogels: An overview of relevant materials and methods DOI Creative Commons

Anita Akbarzadeh Solbu,

David Caballero,

Spyridon Damigos

и другие.

Materials Today Bio, Год журнала: 2022, Номер 18, С. 100537 - 100537

Опубликована: Дек. 29, 2022

Cell migration is essential in numerous living processes, including embryonic development, wound healing, immune responses, and cancer metastasis. From individual cells to collectively migrating epithelial sheets, the locomotion of tightly regulated by multiple structural, chemical, biological factors. However, high complexity this process limits understanding influence each factor. Recent advances materials science, tissue engineering, microtechnology have expanded toolbox allowed development biomimetic

Язык: Английский

Процитировано

73

Cell response to mechanical microenvironment cues via Rho signaling: From mechanobiology to mechanomedicine DOI
Ning Xie, Cailan Xiao,

Qiuai Shu

и другие.

Acta Biomaterialia, Год журнала: 2023, Номер 159, С. 1 - 20

Опубликована: Янв. 28, 2023

Язык: Английский

Процитировано

48

Mechanisms of assembly and remodelling of the extracellular matrix DOI
Alexandra Naba

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 2, 2024

Язык: Английский

Процитировано

45

Extracellular matrix remodeling in the tumor immunity DOI Creative Commons
Wei Du,

Xueming Xia,

Fan Hu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 25, 2024

The extracellular matrix (ECM) is a significant constituent of tumors, fulfilling various essential functions such as providing mechanical support, influencing the microenvironment, and serving reservoir for signaling molecules. abundance degree cross-linking ECM components are critical determinants tissue stiffness. In process tumorigenesis, interaction between immune cells within tumor microenvironment (TME) frequently leads to stiffness, thereby disrupting normal mechanotransduction promoting malignant progression. Therefore, acquiring thorough comprehension dysregulation TME would significantly aid in identification potential therapeutic targets cancer treatment. this regard, we have compiled comprehensive summary encompassing following aspects: (1) principal their roles conditions; (2) intricate TME; (3) pivotal regulators governing onco-immune response ECM.

Язык: Английский

Процитировано

37