Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 25, 2024
The
extracellular
matrix
(ECM)
is
a
significant
constituent
of
tumors,
fulfilling
various
essential
functions
such
as
providing
mechanical
support,
influencing
the
microenvironment,
and
serving
reservoir
for
signaling
molecules.
abundance
degree
cross-linking
ECM
components
are
critical
determinants
tissue
stiffness.
In
process
tumorigenesis,
interaction
between
immune
cells
within
tumor
microenvironment
(TME)
frequently
leads
to
stiffness,
thereby
disrupting
normal
mechanotransduction
promoting
malignant
progression.
Therefore,
acquiring
thorough
comprehension
dysregulation
TME
would
significantly
aid
in
identification
potential
therapeutic
targets
cancer
treatment.
this
regard,
we
have
compiled
comprehensive
summary
encompassing
following
aspects:
(1)
principal
their
roles
conditions;
(2)
intricate
TME;
(3)
pivotal
regulators
governing
onco-immune
response
ECM.
Materials Today Bio,
Год журнала:
2022,
Номер
18, С. 100537 - 100537
Опубликована: Дек. 29, 2022
Cell
migration
is
essential
in
numerous
living
processes,
including
embryonic
development,
wound
healing,
immune
responses,
and
cancer
metastasis.
From
individual
cells
to
collectively
migrating
epithelial
sheets,
the
locomotion
of
tightly
regulated
by
multiple
structural,
chemical,
biological
factors.
However,
high
complexity
this
process
limits
understanding
influence
each
factor.
Recent
advances
materials
science,
tissue
engineering,
microtechnology
have
expanded
toolbox
allowed
development
biomimetic
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 25, 2024
The
extracellular
matrix
(ECM)
is
a
significant
constituent
of
tumors,
fulfilling
various
essential
functions
such
as
providing
mechanical
support,
influencing
the
microenvironment,
and
serving
reservoir
for
signaling
molecules.
abundance
degree
cross-linking
ECM
components
are
critical
determinants
tissue
stiffness.
In
process
tumorigenesis,
interaction
between
immune
cells
within
tumor
microenvironment
(TME)
frequently
leads
to
stiffness,
thereby
disrupting
normal
mechanotransduction
promoting
malignant
progression.
Therefore,
acquiring
thorough
comprehension
dysregulation
TME
would
significantly
aid
in
identification
potential
therapeutic
targets
cancer
treatment.
this
regard,
we
have
compiled
comprehensive
summary
encompassing
following
aspects:
(1)
principal
their
roles
conditions;
(2)
intricate
TME;
(3)
pivotal
regulators
governing
onco-immune
response
ECM.
