Bacterial origins of human cell-autonomous innate immune mechanisms DOI
Tanita Wein, Rotem Sorek

Nature reviews. Immunology, Год журнала: 2022, Номер 22(10), С. 629 - 638

Опубликована: Апрель 8, 2022

Язык: Английский

Cellular senescence in ageing: from mechanisms to therapeutic opportunities DOI
Raffaella Di Micco, Valery Krizhanovsky, Darren J. Baker

и другие.

Nature Reviews Molecular Cell Biology, Год журнала: 2020, Номер 22(2), С. 75 - 95

Опубликована: Дек. 16, 2020

Язык: Английский

Процитировано

1534

Autophagy in healthy aging and disease DOI Open Access
Yahyah Aman, Tomas Schmauck‐Medina, Malene Hansen

и другие.

Nature Aging, Год журнала: 2021, Номер 1(8), С. 634 - 650

Опубликована: Авг. 12, 2021

Язык: Английский

Процитировано

920

Immunogenic cell stress and death DOI Open Access
Guido Kroemer,

Claudia Galassi,

Laurence Zitvogel

и другие.

Nature Immunology, Год журнала: 2022, Номер 23(4), С. 487 - 500

Опубликована: Фев. 10, 2022

Язык: Английский

Процитировано

887

Detection of immunogenic cell death and its relevance for cancer therapy DOI Creative Commons
Jitka Fučíková, Oliver Kepp, Lenka Kašíková

и другие.

Cell Death and Disease, Год журнала: 2020, Номер 11(11)

Опубликована: Ноя. 26, 2020

Abstract Chemotherapy, radiation therapy, as well targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompanied by exposure release numerous damage-associated molecular patterns (DAMPs), altogether confer a robust adjuvanticity dying cancer cells, they favor recruitment activation antigen-presenting cells. ICD-associated DAMPs include surface-exposed calreticulin (CALR) secreted ATP, annexin A1 (ANXA1), type I interferon, high-mobility group box 1 (HMGB1). Additional hallmarks ICD encompass phosphorylation eukaryotic translation initiation factor 2 subunit-α (EIF2S1, better known eIF2α), autophagy, global arrest in transcription translation. Here, we outline methodological approaches for measuring markers vitro ex vivo discovery next-generation antineoplastic agents, development personalized regimens, identification optimal therapeutic combinations clinical management cancer.

Язык: Английский

Процитировано

766

Cellular degradation systems in ferroptosis DOI Open Access
Xin Chen, Chunhua Yu, Rui Kang

и другие.

Cell Death and Differentiation, Год журнала: 2021, Номер 28(4), С. 1135 - 1148

Опубликована: Янв. 18, 2021

Язык: Английский

Процитировано

451

Hallmarks of Health DOI Creative Commons
Carlos López-Otı́n, Guido Kroemer

Cell, Год журнала: 2020, Номер 184(1), С. 33 - 63

Опубликована: Дек. 18, 2020

Язык: Английский

Процитировано

384

The cGAS–STING pathway and cancer DOI

Natasha Samson,

Andrea Ablasser

Nature Cancer, Год журнала: 2022, Номер 3(12), С. 1452 - 1463

Опубликована: Дек. 12, 2022

Язык: Английский

Процитировано

320

The type I interferonopathies: 10 years on DOI Open Access
Yanick J. Crow, Daniel B. Stetson

Nature reviews. Immunology, Год журнала: 2021, Номер 22(8), С. 471 - 483

Опубликована: Окт. 20, 2021

Язык: Английский

Процитировано

319

The role of retrotransposable elements in ageing and age-associated diseases DOI
Vera Gorbunova, Andrei Seluanov, Paolo Mita

и другие.

Nature, Год журнала: 2021, Номер 596(7870), С. 43 - 53

Опубликована: Авг. 4, 2021

Язык: Английский

Процитировано

309

Detection of Viral Infections by Innate Immunity DOI Creative Commons
Michael Carty,

Coralie Guy,

Andrew Bowie

и другие.

Biochemical Pharmacology, Год журнала: 2020, Номер 183, С. 114316 - 114316

Опубликована: Ноя. 2, 2020

Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to infections critically depend on initial activation PRRs by viruses, mainly DNA RNA. The signalling pathways activated leads expression pro-inflammatory cytokines, recruit cells, type I III interferons which induction interferon stimulated genes (ISG), powerful virus restriction factors that establish "antiviral state". Inflammasomes contribute responses through maturation interleukin (IL)-1 IL-18 triggering pyroptotic cell death. activity along with adaptive normally elimination, although disproportionate pathology. In this review we will discuss recent insights into influence PRR what means for mammalian host. We also comment how specific may be relevant SARS-CoV-2, responsible current COVID-19 pandemic, interacts immunity.

Язык: Английский

Процитировано

307