Nature reviews. Immunology, Год журнала: 2022, Номер 22(10), С. 629 - 638
Опубликована: Апрель 8, 2022
Язык: Английский
Nature reviews. Immunology, Год журнала: 2022, Номер 22(10), С. 629 - 638
Опубликована: Апрель 8, 2022
Язык: Английский
Nature Reviews Molecular Cell Biology, Год журнала: 2020, Номер 22(2), С. 75 - 95
Опубликована: Дек. 16, 2020
Язык: Английский
Процитировано
1534Nature Aging, Год журнала: 2021, Номер 1(8), С. 634 - 650
Опубликована: Авг. 12, 2021
Язык: Английский
Процитировано
920Nature Immunology, Год журнала: 2022, Номер 23(4), С. 487 - 500
Опубликована: Фев. 10, 2022
Язык: Английский
Процитировано
887Cell Death and Disease, Год журнала: 2020, Номер 11(11)
Опубликована: Ноя. 26, 2020
Abstract Chemotherapy, radiation therapy, as well targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompanied by exposure release numerous damage-associated molecular patterns (DAMPs), altogether confer a robust adjuvanticity dying cancer cells, they favor recruitment activation antigen-presenting cells. ICD-associated DAMPs include surface-exposed calreticulin (CALR) secreted ATP, annexin A1 (ANXA1), type I interferon, high-mobility group box 1 (HMGB1). Additional hallmarks ICD encompass phosphorylation eukaryotic translation initiation factor 2 subunit-α (EIF2S1, better known eIF2α), autophagy, global arrest in transcription translation. Here, we outline methodological approaches for measuring markers vitro ex vivo discovery next-generation antineoplastic agents, development personalized regimens, identification optimal therapeutic combinations clinical management cancer.
Язык: Английский
Процитировано
766Cell Death and Differentiation, Год журнала: 2021, Номер 28(4), С. 1135 - 1148
Опубликована: Янв. 18, 2021
Язык: Английский
Процитировано
451Cell, Год журнала: 2020, Номер 184(1), С. 33 - 63
Опубликована: Дек. 18, 2020
Язык: Английский
Процитировано
384Nature Cancer, Год журнала: 2022, Номер 3(12), С. 1452 - 1463
Опубликована: Дек. 12, 2022
Язык: Английский
Процитировано
320Nature reviews. Immunology, Год журнала: 2021, Номер 22(8), С. 471 - 483
Опубликована: Окт. 20, 2021
Язык: Английский
Процитировано
319Nature, Год журнала: 2021, Номер 596(7870), С. 43 - 53
Опубликована: Авг. 4, 2021
Язык: Английский
Процитировано
309Biochemical Pharmacology, Год журнала: 2020, Номер 183, С. 114316 - 114316
Опубликована: Ноя. 2, 2020
Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to infections critically depend on initial activation PRRs by viruses, mainly DNA RNA. The signalling pathways activated leads expression pro-inflammatory cytokines, recruit cells, type I III interferons which induction interferon stimulated genes (ISG), powerful virus restriction factors that establish "antiviral state". Inflammasomes contribute responses through maturation interleukin (IL)-1 IL-18 triggering pyroptotic cell death. activity along with adaptive normally elimination, although disproportionate pathology. In this review we will discuss recent insights into influence PRR what means for mammalian host. We also comment how specific may be relevant SARS-CoV-2, responsible current COVID-19 pandemic, interacts immunity.
Язык: Английский
Процитировано
307