Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(2), P. 75 - 95

Published: Dec. 16, 2020

Language: Английский

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Autophagy in healthy aging and disease

Nature Aging, Journal Year: 2021, Volume and Issue: 1(8), P. 634 - 650

Published: Aug. 12, 2021

Language: Английский

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Immunogenic cell stress and death

Nature Immunology, Journal Year: 2022, Volume and Issue: 23(4), P. 487 - 500

Published: Feb. 10, 2022

Language: Английский

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Detection of immunogenic cell death and its relevance for cancer therapy

Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(11)

Published: Nov. 26, 2020

Abstract Chemotherapy, radiation therapy, as well targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompanied by exposure release numerous damage-associated molecular patterns (DAMPs), altogether confer a robust adjuvanticity dying cancer cells, they favor recruitment activation antigen-presenting cells. ICD-associated DAMPs include surface-exposed calreticulin (CALR) secreted ATP, annexin A1 (ANXA1), type I interferon, high-mobility group box 1 (HMGB1). Additional hallmarks ICD encompass phosphorylation eukaryotic translation initiation factor 2 subunit-α (EIF2S1, better known eIF2α), autophagy, global arrest in transcription translation. Here, we outline methodological approaches for measuring markers vitro ex vivo discovery next-generation antineoplastic agents, development personalized regimens, identification optimal therapeutic combinations clinical management cancer.

Language: Английский

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Cellular degradation systems in ferroptosis

Cell Death and Differentiation, Journal Year: 2021, Volume and Issue: 28(4), P. 1135 - 1148

Published: Jan. 18, 2021

Language: Английский

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Hallmarks of Health

Cell, Journal Year: 2020, Volume and Issue: 184(1), P. 33 - 63

Published: Dec. 18, 2020

Language: Английский

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The type I interferonopathies: 10 years on

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 22(8), P. 471 - 483

Published: Oct. 20, 2021

Language: Английский

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The cGAS–STING pathway and cancer

Nature Cancer, Journal Year: 2022, Volume and Issue: 3(12), P. 1452 - 1463

Published: Dec. 12, 2022

Language: Английский

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Detection of Viral Infections by Innate Immunity

Biochemical Pharmacology, Journal Year: 2020, Volume and Issue: 183, P. 114316 - 114316

Published: Nov. 2, 2020

Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to infections critically depend on initial activation PRRs by viruses, mainly DNA RNA. The signalling pathways activated leads expression pro-inflammatory cytokines, recruit cells, type I III interferons which induction interferon stimulated genes (ISG), powerful virus restriction factors that establish "antiviral state". Inflammasomes contribute responses through maturation interleukin (IL)-1 IL-18 triggering pyroptotic cell death. activity along with adaptive normally elimination, although disproportionate pathology. In this review we will discuss recent insights into influence PRR what means for mammalian host. We also comment how specific may be relevant SARS-CoV-2, responsible current COVID-19 pandemic, interacts immunity.

Language: Английский

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The role of retrotransposable elements in ageing and age-associated diseases

Nature, Journal Year: 2021, Volume and Issue: 596(7870), P. 43 - 53

Published: Aug. 4, 2021

Language: Английский

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