International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(5), С. 2638 - 2638
Опубликована: Фев. 27, 2022
Acute
kidney
injury
(AKI)
is
a
life-threatening
condition
characterized
by
rapid
and
transient
decrease
in
function.
AKI
part
of
an
array
conditions
collectively
defined
as
acute
diseases
(AKD).
In
AKD,
persistent
damage
dysfunction
lead
to
chronic
disease
(CKD)
over
time.
A
variety
insults
can
trigger
AKI;
however,
chemotherapy-associated
nephrotoxicity
increasingly
recognized
significant
side
effect
chemotherapy.
New
biomarkers
are
urgently
needed
identify
patients
at
high
risk
developing
subsequent
AKI.
However,
lack
understanding
cellular
mechanisms
that
chemotherapy-related
has
hindered
the
identification
effective
date.
this
review,
we
aim
(1)
describe
known
potential
related
chemotherapy-induced
(2)
summarize
available
for
early
detection,
(3)
raise
awareness
The Nephron journals/Nephron journals,
Год журнала:
2024,
Номер
148(6), С. 408 - 414
Опубликована: Янв. 1, 2024
<b><i>Background:</i></b>
In
daily
practice,
glomerular
filtration
rate
(GFR)
is
estimated
with
equations
including
renal
biomarkers.
Among
these
biomarkers,
serum
creatinine
remains
the
most
used.
However,
there
are
many
limitations
creatinine,
which
we
will
discuss
in
current
review.
We
also
how
creatinine-based
have
been
developed
and
what
can
expect
from
them
terms
of
performance
to
estimate
GFR.
<b><i>Summary:</i></b>
Different
proposed.
show
advantages
recent
European
Kidney
Function
Consortium
equation.
This
equation
be
used
children
adults.
some
flexibility
different
populations.
<b><i>Key
Messages:</i></b>
GFR
by
equations,
but
important
for
nephrologists
probably
know
equations.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 15, 2025
Abstract
Fetal
cell
ablation
models
are
crucial
for
studying
congenital
diseases,
organ
regeneration,
and
xenotransplantation.
However,
conventional
knockout
offer
limited
control
over
disease
severity,
while
conditional
often
require
fetus-harming
inducers.
In
the
present
study,
we
demonstrate
that
inducible
caspase
9
system
enables
precise
targeting
of
fetal
nephron
progenitor
cells
in
mice
through
intrinsic
apoptotic
pathway.
Using
a
safe,
placenta-permeable
inducer,
this
facilitates
specific,
rapid,
efficient
ablation.
The
system’s
temporal
allows
adjustment
generating
reproducible
ranging
from
kidney
deficiency
to
severe
chronic
disease.
Cells
with
low
expression
levels
those
solid
organs
less
susceptible
apoptosis.
limitation
can
be
overcome
by
inhibiting
X-linked
inhibitor
apoptosis
protein,
thereby
expanding
applicability.
Additionally,
model
provides
developmental
environment
suitable
chimeric
regeneration.
This
advances
understanding
induced
death
mechanisms,
enhances
pathological
research
tools,
supports
therapeutic
development
xenotransplantation
applications.
Autoimmunity Reviews,
Год журнала:
2022,
Номер
21(12), С. 103211 - 103211
Опубликована: Окт. 14, 2022
Lupus
nephritis
(LN)
is
a
serious
complication
of
systemic
lupus
erythematosus
(SLE)
that
occurs
in
about
half
patients.
LN
characterized
by
glomerular
deposition
immune
complexes,
leading
to
subendothelial,
mesangial
and
subepithelial
electron
dense
deposits,
triggering
cell
infiltration
as
well
tubulointerstitial
injury.
Monocytes
macrophages
are
abundantly
present
inflammatory
lesions,
both
glomeruli
the
tubulointerstitium.
Here
we
discuss
how
monocytes
involved
this
process
may
represent
specific
therapeutic
targets
control
LN.
Journal of the American Society of Nephrology,
Год журнала:
2023,
Номер
34(7), С. 1264 - 1278
Опубликована: Март 23, 2023
Significance
Statement
Nephron
number
currently
can
be
estimated
only
from
glomerular
density
on
a
kidney
biopsy
combined
with
cortical
volume
imaging.
Because
of
measurement
biases,
refinement
this
approach
and
validation
across
different
patient
populations
have
been
needed.
The
prognostic
importance
nephron
also
has
unclear.
authors
present
an
improved
method
estimating
that
corrects
for
several
resulting
in
27%
higher
estimate
donor
kidneys
compared
prior
method.
After
accounting
comorbidities,
the
new
does
not
differ
between
donors
patients
tumor
shows
consistent
associations
clinical
characteristics
these
two
populations.
findings
indicate
low
predicts
CKD
independent
both
Background
volume.
However,
because
needs
refinement,
comparison
disparate
populations,
evaluation
as
predictor
outcomes.
Methods
We
studied
3020
living
1354
who
underwent
radical
nephrectomy
tumor.
determined
cortex
retained
presurgical
imaging
by
morphometric
analysis
needle
core
donated
wedge
sections
removed
kidney.
Glomerular
was
corrected
missing
tufts,
absence
capsule,
then
tissue
shrinkage
basis
30
autopsy
kidneys.
used
logistic
regression
(in
donors)
Cox
proportional
hazard
models
tumor)
to
assess
risk
outcomes
associated
number.
Results
Donors
had
1.17
million
nephrons
per
kidney;
0.99
A
lower
older
age,
female
sex,
shorter
height,
hypertension,
family
history
ESKD,
GFR,
proteinuria.
adjusting
characteristics,
did
Low
(defined
<5th
or
<10th
percentile
age
sex
healthy
subset)
predicted
future
characteristics.
Conclusions
Compared
number,
addresses
sources
bias
results
estimates
are
1%
consistency
independently
Podcast
This
article
contains
podcast
at
https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2023_06_22_JASN0000000000000124.mp3
