Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Ноя. 1, 2024
Previous observational studies about the link between dietary factors and diabetic microvascular complications (DMCs) is controversial. Thus, we systemically assessed potential causal relationship diet DMCs risk using Mendelian randomization (MR) methods.
Язык: Английский
Nutrients, Год журнала: 2025, Номер 17(4), С. 608 - 608
Опубликована: Фев. 7, 2025
Diabetes and obesity are globally prevalent metabolic disorders posing significant public health challenges. The effective management of these conditions requires integrated personalized strategies. This study conducted a systematic literature review, identifying 335 relevant papers, with 129 core articles selected after screening for duplicates irrelevant studies. focus the is on synergistic roles functional foods, microbiotics, nutrigenomics. Functional including phytochemicals (e.g., polyphenols dietary fibers), zoochemicals essential fatty acids), bioactive compounds from macrofungi, exhibit potential in enhancing insulin sensitivity, regulating lipid metabolism, reducing inflammatory responses, improving antioxidant capacity. Additionally, critical role gut microbiota highlighted, as its interaction foods facilitates modulation pathways. Nutrigenomics, encompassing nutrigenetics genomics, reveals how genetic variations single-nucleotide polymorphisms (SNPs)) influence responses gene expression, forming feedback loop between habits, variations, microbiota, health. review integrates insights to propose comprehensive sustainable nutrition interventions, offering novel perspectives preventing managing type 2 diabetes obesity. Future clinical studies warranted validate long-term efficacy safety
Язык: Английский
Процитировано
1
World Journal of Diabetes, Год журнала: 2024, Номер 16(1)
Опубликована: Ноя. 29, 2024
The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the microbiome a new potential therapeutic focus. This commentary examines recent publication World Journal Diabetes . article explores association between T2DM microbiota, focus on pathophysiological changes related to dysbiosis. It proposes innovative microbiome-targeted strategies evaluates challenges future directions such approaches. editorial summarizes key points their discussion role elaborates influence specific microbial species disease through host–microbiota metabolic axis. provides insights for research gut-microbiota-based interventions T2DM.
Язык: Английский
Процитировано
5
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 10, 2025
Knowledge of the urinary microbiome (urobiome) in diabetic kidney disease (DKD) remains limited. The most commonly used 16S rRNA sequencing technique can only provide bacterial identification at genus level. As a novel technique, 2bRAD for (2bRAD-M) be to identify low-biomass species In this study, we 2bRAD-M compare urobiome composition patients with DKD different stages healthy individuals and those type 2 diabetes mellitus (T2DM), expectation that would find discriminative correlated DKD. Healthy controls, microalbuminuria (DKD1 group) or macroalbuminuria (DKD2 group), T2DM were recruited (n = 20 each group). first-morning urine was collected testing. albumin-to-creatinine ratio (ACR) also measured samples. Serum samples detecting clinical indicators. microbial diversity based on abundance calculated. Differential bacteria groups identified. Besides, correlation between indices analyzed. Urobiome significantly reduced groups. DKD1 group, dominant genus, followed by Pseudomonas_E, whereas DKD2 Pseudomonas_E became Escherichia notably reduced. Both Bifidobacterium Streptococcus, which top genera control substantially decreased included coli Acinetobacter johnsonii, while DKD2, oleovorans, Enterococcus faecalis, Morganella morganii showed strong renal function indicators protein levels. markedly from patients. These findings valuable insights into onset progression DKD, driven changes community structure.
Язык: Английский
Процитировано
0
Food Research International, Год журнала: 2024, Номер 192, С. 114730 - 114730
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
2
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 3, 2024
Diphenyl diselenide (DPDS) ameliorates nephropathy in streptozotocin (STZ)-induced type 1 diabetic rats by inhibiting oxidative stress and inflammatory reactions. However, it has not been clarified whether DPDS alleviates kidney disease (DKD) is related to the inhibition of extracellular matrix (ECM) production regulation intestinal flora disorder.
Язык: Английский
Процитировано
2
Heliyon, Год журнала: 2023, Номер 9(12), С. e22117 - e22117
Опубликована: Ноя. 10, 2023
It aimed to explore the diversity of gut microbiota (GM) and effect different on insulin resistance in diabetes mellitus (DM) patients through bioinformatics analysis.Microarray data were obtained from GEO database. GM samples DM healthy controls collected, 16S rRNA gene sequencing was carried out adopting high-throughput technology. The differential expression genes screened using Qlucore Omics Explorer 3.0 software. Subsequently, online tools such as STRING DAVID utilized for analysis genes. differences bacterial between evaluated by analyzing indicators microbiota, Shannon Chao1 indexes. Differential abundance functional prediction adopted its possible metabolic pathways controls. And specific taxa analyzed.GM had significant differences. lower compared with controls, indicated a decrease showed that there multiple communities including some at genus-level. Functional also revealed potential related patients. HEXB, ZC3H12A, CCR, CXCR3, GBR10, CDK9, TXN, IGFBP3, PDHA1, NDUFB3 may be targets treatment.There are occurrence development resistance.
Язык: Английский
Процитировано
6
Pharmacological Research, Год журнала: 2024, Номер 208, С. 107392 - 107392
Опубликована: Сен. 2, 2024
Diabetic nephropathy (DN) is a major complication of diabetes mellitus (DM) without curative interventions currently. Huperzine A (Hup A), natural alkaloid, has demonstrated significant hypoglycemic and anti-inflammatory effects. We aim to investigate the protective effects Hup on DN explore underlying mechanisms METHODS: applied STZ induced diabetic rats as model leveraged combination analysis transcriptome, metabolome, microbiome, network pharmacology (NP). The total effect was detected (i.e. urine protein, renal tissue structure) differential genes were further verified at level patients, db/db mice cells. Clinical data small interfering RNA (siRNA)-Apoe adopted.
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2024, Номер 14(9), С. 1153 - 1153
Опубликована: Сен. 13, 2024
Deranged gut microbiota can release increased levels of uremic toxins leading to exacerbated kidney injury. In diabetic disease (DKD), phenyl sulfate (PS) derived from tyrosine catabolism by has been demonstrated be both an early diagnostic marker and a therapeutic target. this perspective article, we summarize PS generation pathways recent findings on injury in DKD. Increasing evidence shown that the underlying mechanisms PS-induced mainly involve oxidative stress, redox imbalance, mitochondrial dysfunction, which all may targeted attenuate For future research directions, think deeper understanding pathogenic role using variety animal models should investigated. Moreover, also suggest beneficial approaches could used mitigate deleterious effect kidney. These include caloric restriction, administration ketogenic drugs, diets or natural products; conducted under obese conditions.
Язык: Английский
Процитировано
1
Metabolites, Год журнала: 2023, Номер 13(8), С. 893 - 893
Опубликована: Июль 28, 2023
Complications due to type 2 diabetes mellitus (T2DM) such as diabetic kidney disease (DKD) and cerebral small vessel (CSVD) have a powerful impact on mortality morbidity. Our current diagnostic markers become outdated T2DM-related complications continue develop. The aim of the investigation was point out relationship between previously selected metabolites which are potentially derived from gut microbiota indicators endothelial, proximal tubule (PT), podocyte dysfunction, neurosonological indices. study participants were 20 healthy controls 90 T2DM patients divided into three stages: normoalbuminuria, microalbuminuria, macroalbuminuria. Serum urine determined by untargeted targeted metabolomic techniques. PT dysfunction assessed ELISA technique, indices provided an ultrasound device with high resolution (MYLAB 8-ESAOTE Italy). descriptive statistical analysis followed univariable multivariable linear regression analyses. In conclusion, in serum, arginine (sArg), butenoylcarnitine (sBCA), indoxyl sulfate (sIS) expressed biomarker potential terms renal endothelial carotid atherosclerosis, whereas sorbitol (sSorb) may be blood-brain barrier (BBB) dysfunction. urine, BCA IS associated damage, PCS correlated
Язык: Английский
Процитировано
3
Опубликована: Янв. 1, 2024
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Язык: Английский
Процитировано
0