The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

Australian & New Zealand Journal of Psychiatry, Год журнала: 2020, Номер 55(1), С. 7 - 117

Опубликована: Дек. 22, 2020

Objectives: To provide advice and guidance regarding the management of mood disorders, derived from scientific evidence supplemented by expert clinical consensus to formulate s that maximise utility. Methods: Articles information sourced search engines including PubMed, EMBASE, MEDLINE, PsycINFO Google Scholar were literature known disorders committee (e.g. books, book chapters government reports) published depression bipolar disorder guidelines. Relevant was appraised discussed in detail members committee, with a view formulating developing consensus-based recommendations guidance. The guidelines subjected rigorous consultation external review involving: advisors, key stakeholders, professional bodies specialist groups interest disorders. Results: Royal Australian New Zealand College Psychiatrists practice 2020 (MDcpg ) up-to-date is informed experience. guideline intended for use psychiatrists, psychologists, primary care physicians others an mental health care. Conclusion: MDcpg builds on previous 2015 maintains its joint focus both depressive It provides within evidence-based framework, consensus. Mood committee: Gin S Malhi (Chair), Erica Bell, Darryl Bassett, Philip Boyce, Richard Bryant, Hazell, Malcolm Hopwood, Bill Lyndon, Roger Mulder, Porter, Ajeet B Singh Greg Murray.

Язык: Английский

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The Circadian Syndrome: is the Metabolic Syndrome and much more!

Journal of Internal Medicine, Год журнала: 2019, Номер 286(2), С. 181 - 191

Опубликована: Май 13, 2019

Abstract The Metabolic Syndrome is a cluster of cardio‐metabolic risk factors and comorbidities conveying high both cardiovascular disease type 2 diabetes. It responsible for huge socio‐economic costs with its resulting morbidity mortality in most countries. underlying aetiology this clustering has been the subject much debate. More recently, significant interest focussed on involvement circadian system, major regulator almost every aspect human health metabolism. Circadian now implicated several chronic diseases including diabetes disease. There increasing evidence connecting disturbances rhythm not only key components but also main sleep disturbances, depression, steatohepatitis cognitive dysfunction. Based this, we propose that disruption may be an important aetiological factor suggest it renamed ‘Circadian Syndrome’. With increased recognition Syndrome’, medicine, through timing exercise, light exposure, food consumption, dispensing medications sleep, likely to play greater role maintenance individual population future.

Язык: Английский

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Circadian disruption and human health

Journal of Clinical Investigation, Год журнала: 2021, Номер 131(19)

Опубликована: Сен. 30, 2021

Circadian disruption is pervasive and can occur at multiple organizational levels, contributing to poor health outcomes individual population levels. Evidence points a bidirectional relationship, in that circadian increases disease severity many diseases disrupt rhythms. Importantly, increase the risk for expression development of neurologic, psychiatric, cardiometabolic, immune disorders. Thus, harnessing rich findings from preclinical translational research biology enhance via circadian-based approaches represents unique opportunity personalized/precision medicine overall societal well-being. In this Review, we discuss implications human using bench-to-bedside approach. science applied clinical population-based Given broad regulation health, Review focuses its discussion on selected examples metabolic, cardiovascular, allergic, immunologic disorders highlight interrelatedness between potential interventions, such as bright light therapy exogenous melatonin, well chronotherapy improve and/or modify outcomes.

Язык: Английский

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New Insights Into the Circadian Rhythm and Its Related Diseases

Frontiers in Physiology, Год журнала: 2019, Номер 10

Опубликована: Июнь 25, 2019

Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by the molecular circadian clock which acting on coordinating internal time with external environment in 24-h daily cycle. The system is major regulatory factor for nearly all physiological activities and its disorder has severe consequences human health. CR disruption common issue modern society, researches about people jet lag or shift works have revealed that can cause cognitive impairment, psychiatric illness, metabolic syndrome, dysplasia, cancer. In this review, we summarized synchronizers synchronization methods used experimental research, introduced monitoring detection methods. Moreover, evaluated conventional databases, analyzed experiments characterized underlying causes disorder. Finally, further discussed latest developments understanding disruption, how it may be relevant to health disease. Briefly, review aimed synthesize previous studies aid future CR-related diseases.

Язык: Английский

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Time-restricted Eating for the Prevention and Management of Metabolic Diseases

Endocrine Reviews, Год журнала: 2021, Номер 43(2), С. 405 - 436

Опубликована: Сен. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Язык: Английский

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The Temperature Dependence of Sleep

Frontiers in Neuroscience, Год журнала: 2019, Номер 13

Опубликована: Апрель 24, 2019

Mammals have evolved a range of behavioural and neurological mechanisms that coordinate cycles thermoregulation sleep. Whether diurnal or nocturnal, sleep onset reduction in core temperature occur together. Non-rapid eye movement (NREM) episodes are also accompanied by brain cooling. Thermoregulatory behaviours, like nest building curling up, accompany this circadian decline preparation for sleeping. This could be matter simply comfort as animals seek warmth to compensate lower temperatures. However, both humans other mammals, direct skin warming can shorten sleep-latency promote NREM We discuss the evidence body cooling more fundamentally connected thermoregulatory prior sleep, form warm microclimates accelerate directly through neuronal circuits. Paradoxically, might induce vasodilation In way, seeking nesting behaviour enhance cycle activating specific circuits link initiation suggest these explain why is most likely when at its steepest rate transitions decrease temperature. connection may implications energy homeostasis function

Язык: Английский

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The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology

Bipolar Disorders, Год журнала: 2019, Номер 21(8), С. 741 - 773

Опубликована: Окт. 14, 2019

Abstract Aims To systematically review the literature on efficacy and tolerability of major chronotherapeutic treatments bipolar disorders (BD)—bright light therapy (LT), dark (DT), utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm (IPSRT), cognitive behavioral adapted for BD (CBTI‐BP)—and propose treatment recommendations based a synthesis evidence. Methods PRISMA‐based systematic literature. Results The acute antidepressant (AD) LT was supported by several open‐label studies, three randomized controlled trials (RCTs), one pseudorandomized trial. SD showed rapid, AD response rates 43.9%, 59.3%, 59.4% in eight case series, 11 uncontrolled, RCT, respectively. Adjunctive DT obtained significant, rapid anti‐manic results RCT study. seven studies MA yielded very limited data activity, conflicting evidence both antimanic maintenance efficacy, support from two series improved euthymic states. IPSRT monotherapy II depression had 41%, 67%, 67.4% open respectively; as adjunctive reducing relapse RCTs. Among subjects with insomnia, single found CBTI‐BP effective delaying manic improving sleep. Chronotherapies were generally safe well‐tolerated. Conclusions outcome use BP is variable, bases that differ size, study quality, level evidence, non‐standardized protocols. Evidence‐informed practice are offered.

Язык: Английский

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The microbiota-gut-brain axis in sleep disorders

Sleep Medicine Reviews, Год журнала: 2022, Номер 65, С. 101691 - 101691

Опубликована: Авг. 31, 2022

Язык: Английский

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Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms

Frontiers in Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Авг. 10, 2022

The circadian rhythm is crucial for physiological and behavioral functions. Chronotype, which represents individual preferences activity performance, associated with human health issues, particularly psychiatric disorders. This narrative review, focuses on the relationship between chronotype mental disorders, provides an insight into potential mechanism. Recent evidence indicates that (1) evening a risk factor depressive disorders substance use whereas morning protective factor. (2) Evening individuals bipolar disorder tend to have more severe symptoms comorbidities. (3) only related anxiety symptoms. (4) schizophrenia remains unclear, despite increasing their link. (5) significantly eating majority of studies focused binge Furthermore, underlying mechanisms or influence factors are described in detail, including clock genes, brain characteristics, neuroendocrinology, light/dark cycle, social factors, psychological sleep These findings provide latest chronotypes serve as valuable reference researchers.

Язык: Английский

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Mitochondria: It is all about energy

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Апрель 25, 2023

Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron calcium homeostasis the of hormones neurotransmitters, such as melatonin. They enable influence communication at all physical levels through interaction with other organelles, nucleus, outside environment. The literature suggests crosstalk between mitochondria circadian clocks, gut microbiota, immune system. might even be hub supporting integrating activity across these domains. Hence, they (missing) link Mitochondrial dysfunction related metabolic syndrome, neuronal diseases, cancer, cardiovascular infectious inflammatory disorders. In this regard, diseases Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), pain are discussed. This review focuses on understanding mitochondrial action that allow for maintenance pathways toward dysregulated mechanisms. Although have allowed us adapt changes over course evolution, turn, evolution has shaped mitochondria. Each evolution-based intervention influences its own way. use physiological stress triggers tolerance stressor, achieving adaptability resistance. describes strategies could recover functioning providing comprehensive, root-cause-focused, integrative approach recovering treating people suffering diseases.

Язык: Английский

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