Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely moving macaques DOI Creative Commons
Saman Abbaspoor, Kari L. Hoffman

Cell Reports, Год журнала: 2024, Номер 43(8), С. 114519 - 114519

Опубликована: Июль 16, 2024

Diverse neuron classes in hippocampal CA1 have been identified through the heterogeneity of their cellular/molecular composition. How these relate to function and network dynamics that support cognition primates remains unclear. Here, we report inhibitory functional cell groups freely moving macaques whose diverse response profiles states each other suggest distinct specific roles microcircuit CA1. In addition, pyramidal cells were grouped by superficial or deep layer position differed firing rate, burstiness, sharp-wave ripple-associated firing. They also showed strata-specific spike-timing interactions with groups, suggestive segregated neural populations. Furthermore, ensemble recordings revealed assemblies preferentially organized according strata. These results bears a sublayer-specific circuit organization may shape its role cognition.

Язык: Английский

Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences DOI Open Access
Ning Wang, Yimeng Wang,

Mingkun Guo

и другие.

Опубликована: Фев. 17, 2025

The experience-dependent spatial cognitive process requires sequential organization of hippocampal neural activities by theta rhythm, which develops to represent highly compressed information for rapid learning. However, how the sequences were developed in a finer time scale within cycles remains unclear. In this study, we found that sweep-ahead structure developing with exploration was predominantly dependent on relatively large proportion FG-cells, i.e. subset place cells dominantly phase-locked fast gamma rhythms. These ensembles integrated consistently firing at precessing slow phases cycle. Accordingly, FG-cell positively correlated intensity phase precession, particular during early development sequences. findings highlight dynamic network-modulation and may further facilitate memory encoding retrieval.

Язык: Английский

Процитировано

1
Plasticity mechanism and memory formation in the chemical synapse DOI
Zhao Yao, Kehui Sun, Shaobo He

и другие.

Nonlinear Dynamics, Год журнала: 2023, Номер 111(20), С. 19411 - 19423

Опубликована: Авг. 29, 2023

Язык: Английский

Процитировано

22
A local circuit-basis for spatial navigation and memory processes in hippocampal area CA1 DOI Creative Commons
Tristan Geiller, James B. Priestley, Attila Losonczy

и другие.

Current Opinion in Neurobiology, Год журнала: 2023, Номер 79, С. 102701 - 102701

Опубликована: Март 4, 2023

Язык: Английский

Процитировано

19
An integrated measure of GABA to characterize post-stroke plasticity DOI Creative Commons
Ilenia Paparella, Gilles Vandewalle, Charlotte J. Stagg

и другие.

NeuroImage Clinical, Год журнала: 2023, Номер 39, С. 103463 - 103463

Опубликована: Янв. 1, 2023

Stroke is a major cause of death and chronic neurological disability. Despite the improvements in stroke care, number patients affected by keeps increasing many survivors are left permanently disabled. Current therapies limited efficacy. Understanding neurobiological mechanisms underlying post-stroke recovery therefore crucial to find new therapeutic options address this medical burden. Long-lasting widespread alterations γ-aminobutyric acid (GABA) neurotransmission seem play key role recovery. In review we first discuss possible model GABAergic modulation plasticity. We then overview techniques currently available non-invasively assess GABA conclusions drawn from body work. Finally, remaining open questions clarify changes recovery, briefly ways modulate post propose novel approach thoroughly quantify patients, integrating its concentration, activity receptors link with microstructural changes.

Язык: Английский

Процитировано

19
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus DOI Creative Commons
Erik D. Nelson, Madhavi Tippani, Anthony D. Ramnauth

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 28, 2024

Abstract The hippocampus contains many unique cell types, which serve the structure’s specialized functions, including learning, memory and cognition. These cells have distinct spatial topography, morphology, physiology, connectivity, highlighting need for transcriptome-wide profiling strategies that retain cytoarchitectural organization. Here, we generated spatially-resolved transcriptomics (SRT) single-nucleus RNA-sequencing (snRNA-seq) data from adjacent tissue sections of anterior human across ten adult neurotypical donors. We defined molecular profiles hippocampal types domains. Using non-negative matrix factorization transfer integrated these to define gene expression patterns within snRNA-seq infer in SRT data. With this approach, leveraged existing rodent datasets feature information on circuit connectivity neural activity induction make predictions about axonal projection targets likelihood ensemble recruitment spatially-defined cellular populations hippocampus. Finally, genome-wide association studies with transcriptomic identify enrichment genetic components neurodevelopmental, neuropsychiatric, neurodegenerative disorders domains, To comprehensive atlas accessible scientific community, both raw processed are freely available, through interactive web applications.

Язык: Английский

Процитировано

8
Mystery of the memory engram: History, current knowledge, and unanswered questions DOI Creative Commons
Matthew R. Lopez,

S.M.H. Wasberg,

Celia Gagliardi

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 159, С. 105574 - 105574

Опубликована: Фев. 6, 2024

The quest to understand the memory engram has intrigued humans for centuries. Recent technological advances, including genetic labelling, imaging, optogenetic and chemogenetic techniques, have propelled field of research forward. These tools enabled researchers create erase components. While these innovative techniques yielded invaluable insights, they often focus on specific elements trace. Genetic labelling may rely a particular immediate early gene as marker activity, optogenetics activate or inhibit one type neuron, imaging capture activity snapshots in given brain region at times. Yet, memories are multifaceted, involving diverse arrays neuronal subpopulations, circuits, regions that work concert create, store, retrieve information. Consideration contributions both excitatory inhibitory neurons, micro macro circuits across regions, dynamic nature active ensembles, representational drift is crucial comprehensive understanding complex memory.

Язык: Английский

Процитировано

7
Ultraviolet-driven metal oxide semiconductor synapses with improved long-term potentiation DOI

Shuwen Xin,

Yu Chang,

Ruifu Zhou

и другие.

Journal of Materials Chemistry C, Год журнала: 2022, Номер 11(2), С. 722 - 729

Опубликована: Дек. 6, 2022

We fabricated bio-inspired synaptic transistors based on one dimensional InZnO nanowires, which can be effectively tuned by ultraviolet laser to achieve hour-scale long-memory retention of long-term potentiation.

Язык: Английский

Процитировано

24
Inhibitory circuits in fear memory and fear-related disorders DOI Creative Commons
Sanjay Singh, Lisa Topolnik

Frontiers in Neural Circuits, Год журнала: 2023, Номер 17

Опубликована: Март 23, 2023

Fear learning and memory rely on dynamic interactions between the excitatory inhibitory neuronal populations that make up prefrontal cortical, amygdala, hippocampal circuits. Whereas inhibition of principal cells (PCs) by GABAergic neurons restrains their excitation, promotes excitation PCs through a process called disinhibition. Specifically, interneurons express parvalbumin (PV+) somatostatin (SOM+) provide to different subcellular domains PCs, whereas those vasoactive intestinal polypeptide (VIP+) facilitate disinhibition inhibiting PV+ SOM+ interneurons. Importantly, although main connectivity motifs underlying network functions PV+, SOM+, VIP+ are replicated across cortical limbic areas, these play region-specific roles in fear memory. Here, we an overview processing hippocampus, cortex based evidence obtained human animal studies. Moreover, focusing recent findings using genetically defined imaging intervention strategies, discuss population-specific Last, review current insights integrate disinhibitory patterns into acquisition fear-related disorders.

Язык: Английский

Процитировано

15
Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues DOI Creative Commons
Michael D. Hadler, Henrik Alle,

Jörg R. P. Geiger

и другие.

Trends in Pharmacological Sciences, Год журнала: 2024, Номер 45(7), С. 586 - 601

Опубликована: Май 18, 2024

Alzheimer's disease (AD) and schizophrenia (SCZ) represent two major neuropathological conditions with a high burden. Despite their distinct etiologies, patients suffering from AD or SCZ share common burden of disrupted memory functions unattended by current therapies. Recent preclinical analyses highlight cell-type-specific contributions parvalbumin interneurons (PVIs), particularly the plasticity cellular excitability, towards intact neuronal network function (cell-to-network plasticity) performance. Here we argue that deficits PVI cell-to-network may underlie in SCZ, explore therapeutic avenues: targeting PVI-specific neuromodulation, including neuropeptides, recruitment synchrony gamma frequency range (40 Hz) external stimulation. We finally propose these approaches be merged under consideration recent insights into human brain physiology.

Язык: Английский

Процитировано

6
Efficient learning in children with rapid GABA boosting during and after training DOI Creative Commons
Sebastian Frank, Markus C. Becker, Andrea Qi

и другие.

Current Biology, Год журнала: 2022, Номер 32(23), С. 5022 - 5030.e7

Опубликована: Ноя. 16, 2022

It is generally thought that children learn more efficiently than adults. One way to accomplish this have learning rapidly stabilized such it not interfered with by subsequent learning. Although γ-aminobutyric acid (GABA) plays an important role in stabilization, has been reported GABAergic inhibitory processing fully matured yet compared Does finding indicate efficient due rapid stabilization? Here, we measured the concentration of GABA early visual cortical areas a time-resolved fashion before, during, and after perceptual (VPL) within subjects using functional MRS (fMRS) then concentrations between (8 11 years old) adults (18 35 old). We found exhibited boost during training persisted ended, whereas remained unchanged. Moreover, behavioral experiments showed development resilience retrograde interference, which indicates stabilize VPL much faster These results together suggest children's brains dynamic adapts quickly adults, making children.

Язык: Английский

Процитировано

23