Microgliosis, astrogliosis and loss of aquaporin-4 polarity in frontal cortex of COVID-19 patients DOI Creative Commons
Antonia Beiersdorfer,

Natalie Rotermund,

Kristina Schulz

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 11, 2024

Abstract The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), causing human disease 2019 (COVID-19), not only affects the tract, but also impacts other organs including brain. A considerable number of COVID-19 patients develop neuropsychiatric symptoms that may linger for weeks and months contribute to “long-COVID”. While neurological are well described, cellular mechanisms neurologic disorders attributed infection still enigmatic. Here, we studied effect an with SARS-CoV-2 on structure expression marker proteins astrocytes microglial cells in frontal cortex who died from comparison non-COVID-19 controls. Most had retracted processes rounded enlarged cell bodies both gray white matter, as visualized by anti-Iba1 staining confocal fluorescence microscopy. In addition, matter were frequently labeled intense anti-GFAP staining, whereas controls, most expressed little GFAP. striking difference between controls was found anti-aquaporin-4 (AQP4) staining. patients, a large showed increase AQP4. AQP4 polarity lost covered entire cell, body all processes, while immunostaining mainly detected endfeet around blood vessels did visualize body. summary, our data suggest neuroinflammation upon microgliosis astrogliosis, loss polarity.

Язык: Английский

Post-COVID cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction: national prospective study DOI Creative Commons
Benedict Michael, Greta K. Wood, Brendan Sargent

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 5, 2024

Abstract The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention treatment strategies. We report the one-year cognitive, serum biomarker, neuroimaging findings from a prospective, national longitudinal study cognition in 351 COVID-19 patients who had required hospitalisation, compared 2,927 normative matched controls. Cognitive were global associated with elevated brain injury markers reduced anterior cingulate cortex volume one year after admission. severity initial infective insult, post-acute psychiatric symptoms, history encephalopathy greatest deficits. There was strong concordance between subjective objective Treatment corticosteroids during acute phase appeared protective against Together, these support hypothesis that moderate severe is immune-mediated, should guide development therapeutic

Язык: Английский

Процитировано

7
Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions DOI Creative Commons
Yong Qiu, Chunheng Mo, Lu Chen

и другие.

MedComm, Год журнала: 2024, Номер 5(4)

Опубликована: Март 15, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.

Язык: Английский

Процитировано

6
Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations DOI Creative Commons
Leonie Kausel, Alejandra Figueroa-Vargas, Francisco Zamorano

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 17, 2024

Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms risk factors underlying these alterations remain elusive. Given significant global incidence of COVID-19, identifying that can distinguish individuals at developing is crucial for prioritizing follow-up care. Here, we report findings a sample patients consisting 73 adults with mild to moderate SARS-CoV-2 infection without signs respiratory failure 27 infections attributed other agents no history COVID-19. The participants underwent screening, decision-making task, MRI evaluations. We assessed presence anosmia requirement hospitalization. Groups did not differ in age or performance. who presented exhibited more impulsive alternative changes after shift probabilities (r = − 0.26, p 0.001), while required hospitalization showed perseverative choices 0.25, 0.003). Anosmia correlated measures, including decreased functional activity during thinning cortical thickness parietal regions, loss white matter integrity. Hence, could be factor considered when at-risk populations follow-up.

Язык: Английский

Процитировано

6
Neurological complications caused by SARS-CoV-2 DOI
Zehan Pang, Ao Tang,

Yujie He

и другие.

Clinical Microbiology Reviews, Год журнала: 2024, Номер 37(4)

Опубликована: Сен. 18, 2024

SUMMARYSARS-CoV-2 can not only cause respiratory symptoms but also lead to neurological complications. Research has shown that more than 30% of SARS-CoV-2 patients present neurologic during COVID-19 (A. Pezzini and A. Padovani, Nat Rev Neurol 16:636-644, 2020, https://doi.org/10.1038/s41582-020-0398-3). Increasing evidence suggests invade both the central nervous system (CNS) (M.S. Xydakis, M.W. Albers, E.H. Holbrook, et al. Lancet 20: 753-761, 2021 https://doi.org/10.1016/S1474-4422(21)00182-4 ) peripheral (PNS) (M.N. Soares, M. Eggelbusch, E. Naddaf, J Cachexia Sarcopenia Muscle 13:11-22, 2022, https://doi.org/10.1002/jcsm.12896), resulting in a variety disorders. This review summarized CNS complications caused by infection, including encephalopathy, neurodegenerative diseases, delirium. Additionally, some PNS disorders such as skeletal muscle damage inflammation, anosmia, smell or taste impairment, myasthenia gravis, Guillain-Barré syndrome, ICU-acquired weakness, post-acute sequelae were described. Furthermore, mechanisms underlying SARS-CoV-2-induced discussed, entering brain through retrograde neuronal hematogenous routes, disrupting normal function cytokine storms, inducing cerebral ischemia hypoxia, thus leading Moreover, an overview long-COVID-19 is provided, along with recommendations for care therapeutic approaches experiencing

Язык: Английский

Процитировано

6
Basic implications on three pathways associated with SARS-CoV-2 DOI Creative Commons
Jong‐Hoon Lee, Consolato Sergi, Richard E. Kast

и другие.

Biomedical Journal, Год журнала: 2024, Номер unknown, С. 100766 - 100766

Опубликована: Июль 1, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts between the host and virus govern induction, resulting in multiorgan impacts. Its pathophysiology involves followings: 1) angiotensin-converting enzyme (ACE2) Toll-like receptor (TLR) pathways: 2) neuropilin (NRP) pathway: 3) spike protein pathway. Therefore, it is necessary to block pathological course with modulating innate lymphoid cells against diverse corona variants future.

Язык: Английский

Процитировано

4
The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19 DOI Creative Commons
Xuan Niu,

Wenrui Bao,

Zhaoyao Luo

и другие.

NeuroImage, Год журнала: 2025, Номер 306, С. 121011 - 121011

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

0
Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19 DOI Creative Commons
Abigail Vanderheiden, Michael Diamond

Viruses, Год журнала: 2025, Номер 17(1), С. 98 - 98

Опубликована: Янв. 14, 2025

Post-acute sequelae of COVID-19 (PASC) are a diverse set symptoms and syndromes driven by dysfunction multiple organ systems that can persist for years negatively impact the quality life millions individuals. We currently lack specific therapeutics patients with PASC, due in part to an incomplete understanding its pathogenesis, especially non-pulmonary sequelae. Here, we discuss three animal models have been utilized investigate PASC: non-human primates (NHPs), hamsters, mice. focus on neurological, gastrointestinal, cardiovascular PASC highlight advances mechanistic insight made using these models, as well discussing warrant continued intensive research.

Язык: Английский

Процитировано

0
Post-COVID-19 Era Forensics: Hospital Autopsies, New Methodologies, and Medicolegal Perspectives DOI Creative Commons
Simona Zaami, Gabriele Napoletano, Enrico Marinelli

и другие.

Forensic Sciences, Год журнала: 2025, Номер 5(1), С. 8 - 8

Опубликована: Фев. 12, 2025

Background: Hospital autopsies, once considered fundamental to evidence-based medicine, have declined in many Western countries due legislative changes, faith-based objections, and inadequate funding public healthcare. However, the COVID-19 pandemic has revitalized interest their importance for determining cause of death generating health statistics. This study analyzes factors contributing this decline, with a focus on Italian context new medicolegal perspectives arising post-pandemic era. Methods: The research was conducted through an analysis 91 relevant scientific sources, including government documents, policy briefs, academic studies. Legislative regulatory influencing reduction hospital autopsies were examined, along technological that emerged following pandemic. Special attention given pandemic’s impact autopsy practices. Results: revealed perceived “low value” often stems from advancements, which led view these procedures as redundant. post-COVID-19 era, there been renewed awareness value significant implications statistics evolution forensic medicine. Conclusions: highlighted vital role delivering accurate medical information, prompting Moving forward, will need balance innovations traditional practices, paving way medicine data management.

Язык: Английский

Процитировано

0
Biophysics of SARS-CoV-2 spike protein’s receptor-binding domain interaction with ACE2 and neutralizing antibodies: from computation to functional insights DOI
Fernando Luís Barroso da Silva,

Karen Paco,

Aatto Laaksonen

и другие.

Biophysical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Язык: Английский

Процитировано

0
Updates on the neurological manifestations of SARS-CoV-2 infection DOI
Ferron F. Ocampo, Kathryn B. Holroyd

Current Opinion in Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Purpose of review Since its emergence in 2020, the COVID-19 pandemic has created a global surge survivors experiencing neurologic effects from SARS-CoV-2 infection. This aims to provide an updated synthesis acute and chronic neurological manifestations COVID-19, outline current therapeutic strategies for these conditions. Recent findings Epidemiological studies have shown that patients with symptoms during infection tend poorer hospital functional outcomes. While risk adverse including cognitive dysfunction, headache, autonomic fatigue are thought be greatest following original strain alpha variant, they remain prevalent after subsequent less virulent strains as well. Some recent work also found link between structural brain changes. However, ongoing trials show promising results pharmacologic nonpharmacologic treatments targeting postacute sequelae COVID-19. Summary Lingering still pose considerable individual, healthcare system, socioeconomic repercussions. Both preventive multimodal treatment approaches necessary address Further research is required assess lasting impacts on nervous particularly potential contribution development neurodegenerative diseases.

Язык: Английский

Процитировано

0