Light Science & Applications,
Год журнала:
2021,
Номер
10(1)
Опубликована: Май 28, 2021
Abstract
Circulating
tumor
cells
(CTCs)
is
an
established
biomarker
of
cancer
metastasis.
The
circulation
dynamics
CTCs
are
important
for
understanding
the
mechanisms
underlying
cell
dissemination.
Although
studies
have
revealed
that
circadian
rhythm
may
disrupt
growth
tumors,
it
generally
unclear
whether
controls
release
CTCs.
In
clinical
examinations,
current
in
vitro
methods
detecting
blood
samples
based
on
a
fundamental
assumption
CTC
counts
peripheral
do
not
change
significantly
over
time,
which
being
challenged
by
recent
studies.
Since
practical
to
draw
from
patients
repeatedly,
feasible
strategy
investigate
monitor
them
vivo
detection
methods.
Fluorescence
flow
cytometry
(IVFC)
powerful
optical
technique
able
detect
fluorescent
circulating
directly
living
animals
noninvasive
manner
long
period
time.
this
study,
we
applied
fluorescence
IVFC
noninvasively
orthotopic
mouse
model
human
prostate
cancer.
We
observed
exhibited
stochastic
bursts
progression.
probability
bursting
activity
was
higher
at
early
stages
than
late
stages.
longitudinally
monitored
24-h
period,
and
our
results
striking
daily
oscillations
peaked
onset
night
(active
phase
rodents),
suggesting
might
be
regulated
rhythm.
Abstract
Circadian
clocks
are
endogenous
oscillators
that
control
24-h
physiological
and
behavioral
processes.
The
central
circadian
clock
exerts
over
myriad
aspects
of
mammalian
physiology,
including
the
regulation
sleep,
metabolism,
immune
system.
Here,
we
review
advances
in
understanding
genetic
sleep
through
system,
as
well
impact
dysregulated
gene
expression
on
metabolic
function.
We
also
recent
studies
have
begun
to
unravel
clock’s
role
controlling
cardiovascular
nervous
systems,
gut
microbiota,
cancer,
aging.
Such
these
systems
relies,
part,
transcriptional
regulation,
with
evidence
for
genome-wide
chromosome
organization.
These
novel
insights
into
genomic
human
physiology
provide
opportunities
discovery
improved
treatment
strategies
new
biological
underpinnings
disease.
The Journal of Experimental Medicine,
Год журнала:
2020,
Номер
217(3)
Опубликована: Фев. 13, 2020
The
cytokine
interleukin-22
(IL-22)
is
a
critical
regulator
of
epithelial
homeostasis.
It
has
been
implicated
in
multiple
aspects
barrier
function,
including
regulation
cell
growth
and
permeability,
production
mucus
antimicrobial
proteins
(AMPs),
complement
production.
In
this
review,
we
focus
specifically
on
the
role
IL-22
intestinal
epithelium.
We
summarize
recent
advances
our
understanding
how
regulates
homeostasis
host
defense,
discuss
pathway
as
therapeutic
target
diseases
intestine,
inflammatory
bowel
disease
(IBD),
graft-versus-host
(GVHD),
cancer.
Regulating
multiple
body
clocks
Circadian
rhythms
that
affect
tissues
and
organ
systems
are
aligned
with
the
dark-light
cycle
other
external
inputs
such
as
feeding.
But
how
is
time
keeping
modulated
throughout
complex
anatomical
regions?
Koronowski
Sassone-Corsi
reviewed
central
regulators
in
brain
peripheral
organs
can
behave
cooperatively
or
independently
to
modulate
circadian
rhythms.
This
systemic
view
of
rhythm
modulation
important
understand
behavior
disease,
because
dysregulated
associated
metabolic
syndrome
cancer.
Science
,
this
issue
p.
eabd0951
Mucosal Immunology,
Год журнала:
2021,
Номер
14(3), С. 555 - 565
Опубликована: Фев. 4, 2021
The
gastrointestinal
tract
is
densely
innervated
by
a
complex
network
of
neurons
that
coordinate
critical
physiological
functions.
Here,
we
summarize
recent
studies
investigating
the
crosstalk
between
gut-innervating
neurons,
resident
immune
cells,
and
epithelial
cells
at
homeostasis
during
infection,
food
allergy,
inflammatory
bowel
disease.
We
introduce
neuroanatomy
tract,
detailing
gut-extrinsic
neuron
populations
from
spinal
cord
brain
stem,
intrinsic
enteric
nervous
system.
highlight
roles
these
play
in
regulating
functions
innate
adaptive
intestinal
cells.
discuss
consequences
such
signaling
for
mucosal
immunity.
Finally,
how
microbiota
integrated
into
neuro-immune
axis
tuning
neuronal
interactions.
Understanding
molecular
events
governing
axes
will
enhance
our
knowledge
physiology
may
provide
novel
therapeutic
targets
to
treat
diseases.
