Decoding the neurocircuitry of gut feelings: Region-specific microbiome-mediated brain alterations DOI Creative Commons

B. Sharvin,

María R. Aburto, John F. Cryan

и другие.

Neurobiology of Disease, Год журнала: 2023, Номер 179, С. 106033 - 106033

Опубликована: Фев. 8, 2023

Research in the last decade has unveiled a crucial role for trillions of microorganisms that reside gut influencing host neurodevelopment across lifespan via microbiota-gut-brain axis. Studies have linked alterations composition, complexity, and diversity microbiota to changes behaviour including abnormal social interactions, cognitive deficits, anxiety- depressive-like phenotypes. Moreover, been with neurodevelopmental, neuropsychiatric, neurodegenerative disorders. Interestingly, there appears be specific brain regions governing neurocircuitry driving higher function are susceptible influence from manipulations microbiome. This review will aim elucidate region-specific effects mediated by microbiota, focus on translational animal models some existing human neuroimaging data. Compelling preclinical evidence suggests disruption normal signalling can detrimental prefrontal cortex, amygdala, hippocampus, hypothalamus, striatum. Furthermore, studies mediating functional connectivity structure traced back neurocognition behavioural output. Understanding these microbiota-mediated aid identifying unique therapeutic targets treating neurological disorders associated regions.

Язык: Английский

Brain–gut–microbiota axis in depression: A historical overview and future directions DOI Creative Commons
Lijia Chang, Wei Yan, Kenji Hashimoto

и другие.

Brain Research Bulletin, Год журнала: 2022, Номер 182, С. 44 - 56

Опубликована: Фев. 11, 2022

Depression is the most common mental disorder and a leading cause of disability worldwide. Despite abundant research, precise mechanisms underlying pathophysiology depression remain elusive. Accumulating evidence from preclinical clinical studies suggests that alterations in gut microbiota, microbe-derived short-chain fatty acids, D-amino acids metabolites play key role via brain–gut–microbiota axis, including neural immune systems. Notably, axis might crucial susceptibility versus resilience rodents exposed to stress. Vagotomy reported block depression-like phenotypes after fecal microbiota transplantation "depression-related" microbiome, suggesting vagus nerve influences through axis. In this article, we review recent findings regarding discuss its potential as therapeutic target for depression.

Язык: Английский

Процитировано

244
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases DOI Creative Commons
Jian Sheng Loh, Wen Qi Mak, Li Tan

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Язык: Английский

Процитировано

231
Bacteroides species differentially modulate depression-like behavior via gut-brain metabolic signaling DOI

Youying Zhang,

Qilin Fan,

Yuanlong Hou

и другие.

Brain Behavior and Immunity, Год журнала: 2022, Номер 102, С. 11 - 22

Опубликована: Фев. 7, 2022

Язык: Английский

Процитировано

128
Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice DOI Creative Commons
Chiang‐Wen Lee, Lee‐Fen Hsu,

I.-Lin Wu

и другие.

Journal of Hazardous Materials, Год журнала: 2022, Номер 430, С. 128431 - 128431

Опубликована: Фев. 4, 2022

Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its potential effects on health remain unknown. The administration of polystyrene MPs (PS-MPs) to mice for eight weeks impaired learning and memory behavior. PS-MPs were detected in the brain especially hippocampus these mice. Concurrently, had decreased levels immediate-early genes, aberrantly enhanced synaptic glutamate AMPA receptors, elevated neuroinflammation, all which are critical plasticity memory. Interestingly, ablation vagus nerve, modulator gut-brain axis, improved function These results indicate that exposure alters expression neuronal activity-dependent genes proteins, increases neuroinflammation hippocampus, subsequently causing behavioral changes through nerve-dependent pathway. Our findings shed light adverse impacts hippocampal

Язык: Английский

Процитировано

118
The microbiota–gut–brain axis and neurodevelopmental disorders DOI Creative Commons
Qinwen Wang,

Qianyue Yang,

Xingyin Liu

и другие.

Protein & Cell, Год журнала: 2023, Номер 14(10), С. 762 - 775

Опубликована: Май 11, 2023

Abstract The gut microbiota has been found to interact with the brain through microbiota–gut–brain axis, regulating various physiological processes. In recent years, impacts of on neurodevelopment this axis have increasingly appreciated. is commonly considered regulate three pathways, immune pathway, neuronal and endocrine/systemic overlaps crosstalks in between. Accumulating studies identified role neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity Rett Syndrome. Numerous researchers examined pathophysiological mechanisms influenced by (NDDs). This review aims provide a comprehensive overview advancements research pertaining microbiota-gut-brain NDDs. Furthermore, we analyzed both current state progress discuss future perspectives field.

Язык: Английский

Процитировано

106
The gut microbiome and mental health: advances in research and emerging priorities DOI
Andrew Shoubridge, Jocelyn M. Choo, Alyce M. Martin

и другие.

Molecular Psychiatry, Год журнала: 2022, Номер 27(4), С. 1908 - 1919

Опубликована: Март 2, 2022

Язык: Английский

Процитировано

81
How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics DOI Open Access
Kazunori Suda, Kazunori Matsuda

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1172 - 1172

Опубликована: Янв. 21, 2022

Accumulating evidence suggests that the gut microbiome influences brain functions and psychological state of its host via gut–brain axis, dysbiosis has been linked to several mental illnesses, including major depressive disorder (MDD). Animal experiments have shown a depletion microbiota leads behavioral changes, is associated with pathological abnormal stress response impaired adult neurogenesis. Short-chain fatty acids such as butyrate are known contribute up-regulation brain-derived neurotrophic factor (BDNF), causes decreased levels BDNF, which could affect neuronal development synaptic plasticity. Increased permeability an influx microbial components lipopolysaccharides, resultant systemic inflammation may lead neuroinflammation in central nervous system. In light fact factors initiation exacerbation symptoms, this review summarizes current understanding molecular mechanisms involved MDD onset, discusses therapeutic potential probiotics, butyrate-producing bacteria, can mediate microbiota–gut–brain axis.

Язык: Английский

Процитировано

79
Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease DOI Creative Commons
Clara Abraham, María T. Abreu, Jerrold R. Turner

и другие.

Gastroenterology, Год журнала: 2022, Номер 162(6), С. 1602 - 1616.e6

Опубликована: Фев. 9, 2022

Язык: Английский

Процитировано

72
The gut microbiome in social anxiety disorder: evidence of altered composition and function DOI Creative Commons
Mary I. Butler, Thomaz F. S. Bastiaanssen,

Caitríona M. Long-Smith

и другие.

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Март 20, 2023

Abstract The microbiome-gut-brain axis plays a role in anxiety, the stress response and social development, is of growing interest neuropsychiatric conditions. gut microbiota shows compositional alterations variety psychiatric disorders including depression, generalised anxiety disorder (GAD), autism spectrum (ASD) schizophrenia but studies investigating microbiome (SAD) are very limited. Using whole-genome shotgun analysis 49 faecal samples (31 cases 18 sex- age-matched controls), we analysed functional differences patients with SAD comparison to healthy controls. Overall composition, as measured by beta-diversity, was found be different between control groups several taxonomic were seen at genus- species-level. relative abundance genera Anaeromassillibacillus Gordonibacter elevated SAD, while Parasuterella enriched At species-level, A naeromassilibacillus sp An250 more abundant Parasutterella excrementihominis higher No alpha diversity. In relation differences, metabolic module ‘aspartate degradation I’ patients. conclusion, differs composition function that Larger, longitudinal warranted validate these preliminary results explore clinical implications changes.

Язык: Английский

Процитировано

61
The gut microbiome modulates the transformation of microglial subtypes DOI Creative Commons
Yu Huang, Jing Wu,

Hanping Zhang

и другие.

Molecular Psychiatry, Год журнала: 2023, Номер 28(4), С. 1611 - 1621

Опубликована: Март 13, 2023

Abstract Clinical and animal studies have shown that gut microbiome disturbances can affect neural function behaviors via the microbiota–gut–brain axis, may be implicated in pathogenesis of several brain diseases. However, exactly how modulates nervous system activity remains obscure. Here, using a single-cell nucleus sequencing approach, we sought to characterize cell type–specific transcriptomic changes prefrontal cortex hippocampus derived from germ-free (GF), specific pathogen free, colonized-GF mice. We found absence microbiota resulted cell-specific changes. Furthermore, microglia transcriptomes were preferentially influenced, which could effectively reversed by microbial colonization. Significantly, modulated mutual transformation microglial subpopulations two regions. Cross-species analysis showed transcriptome these mainly associated with Alzheimer’s disease (AD) major depressive disorder (MDD), further supported behavioral tests. Our findings demonstrate modulate subtypes, lead new insights into AD MDD.

Язык: Английский

Процитировано

50